White Blood Cell Pathology 1

Question 1

name the classification system for hematopoietic neoplasm

Answer 1

WHO

Question 2

How does one determine the Immunophenotype of a cell

Answer 2

flow cytometry

Question 3

CD 34

Answer 3

immature

Question 4

CD 13, 33, MPO

Answer 4

myeloid

Question 5

CD19, 20, kappa and lambda light chaines

Answer 5

B cell

Question 6

CD1A, 3, 4, 8, 7, 5

Answer 6

T cell

Question 7

name 6 ways a cell becomes neoplastic

Answer 7

• chromosomal translocation/mutations
• inherited genetic factors
• viruses
• environmental factors
• iatrogenic factors
• smoking

Question 8

Follicular lymphoma

Answer 8

t (14;18)

Question 9

Burkitt lymphoma

Answer 9

t(8;14)

Question 10

mantle cell lymphoma

Answer 10

t(11;14)

Question 11

acute promyelocytic leukemia

Answer 11

t ( 15;17)

Question 12

chronic myelogenous leukemia

Answer 12

t (9;22)

Question 13

what genetic factor increases risk for acute leukemia

Answer 13

fanconi anemia

Question 14

what inherited genetic factors increase risk for childhood leukemia

Answer 14

down syndrome

nuerofibromatosis I

Question 15

name 3 viruses that cause cells to turn neoplastic

Answer 15

HTLV-1
HHV-8
EBV

Question 16

HTLV-1 associated with what

Answer 16

Adult T cell leukemia/lymphoma (ATLL)

Question 17

HHV8 associated with what

Answer 17

pleural effusion lymphoma

Question 18

what is adult T cell leukemia/lymphoma (ATLL)

Answer 18

neoplastic proliferation of mature CD4 T cells

Question 19

what race is Adult T cell leukemia/lymphoma seen in

Answer 19

Japan and Caribbean

Question 20

what are clinical features for adult T cell leukemia/lymphoma

Answer 20

1. rash (skin infiltration)
2. lymphadenopathy/hepatosplenomegaly
3. lytic (punched-out) bone lesions with hypercalcemia

Question 21

EBV is seen with what diseases

Answer 21

Burkitt lymphoma
hodgkin lymphoma ( some)
Immunodeficiency associated B cell lymphoma
rare NK cell lymphomas

Question 22

smoking increases the chances of what

Answer 22

acute myeloid leukemia

Question 23

H. pylori can cause

Answer 23

MALT lymphomas of stomach

Question 24

Hashimoto’s thyroiditis

Answer 24

MALT lymphoma of thyroid

Question 25

Celiac disease

Answer 25

intestinal t cell lymphoma

Question 26

lymphadenopathy

Answer 26

lymph node enlargement ( tender or non-tender)

Question 27

lymphadenitis

Answer 27

lymph node inflammation ( typically tender)

Question 28

what are 3 autoimmune disorders that cause lymphadenopathy

Answer 28

- Sjogren syndrome - Rheumatoid arthritis - System Lupus erythematosus

Question 29

what are some infections that cuase lymphadenopathy

Answer 29

viral bacterial protozoal ( toxoplasmosis) fungal ( histoplasmosis)

Question 30

what are iatrogenic causes of lymphadenopathy

Answer 30

silicone

Question 31

Follicular hyperplasia stimulates what cells

Answer 31

B cells

Question 32

where does follicular hyperplasia occur

Answer 32

- germinal centers | - mantle zone

Question 33

what are some eitologies for follicular hyperplasia

Answer 33

Bacterial, toxoplasmosis rheumatoid arthritis early HIV infection

Question 34

Follicular hyperplasia vs. follicular lymphoma: architecture

Answer 34

H: normal with follicles varying in size L: disruption by follicles of similar size

Question 35

Follicular hyperplasia vs. follicular lymphoma: mantle zone

Answer 35

H: polarized L: no polarized

Question 36

Follicular hyperplasia vs. follicular lymphoma: marcrophages

Answer 36

H: tingable body macrophages L: no tingable body macrophages

Question 37

Follicular hyperplasia vs. follicular lymphoma: bcl2 pattern

Answer 37

H: normal L: reverse

Question 38

what does bcl2 normally stain in a lymph node

Answer 38

mantle cells | turned off in germinal centers

Question 39

paracortical hyperplasia stimulates what cells

Answer 39

T cells

Question 40

Etiologies for paracrotical hyperplasia

Answer 40

VIRAL INFECTIONS - mono | DRUGS

Question 41

what is located in sinus histiocytosis

Answer 41

macrophages

Question 42

lymphadenopathies name 3 types

Answer 42

follicular hyperplasia paracortical hyperplasia Sinus histiocytosis

Question 43

what are two types of lymphadenitis

Answer 43

acute nonspecific | chronic nonspecific

Question 44

characteristics of acute nonspecific lymphadenitis

Answer 44

enlarged, red tender, soft noes

Question 45

characteristic of chronic nonspecific lymphadenitis? what can cause this

Answer 45

non-tender nodes | -chronic immunologic stimulation

Question 46

what is the most common lymphadenitis in children

Answer 46

acute nonspecific lymphadentitis

Question 47

what can cause acute nonspecific lymphadentitis

Answer 47

drainage of infections

Question 48

lymphoma vs leukemia location

Answer 48

lymphoma: tissue leukemia: blood or bone marrow

Question 49

how do 2/3 of lymphoma's present? the rest

Answer 49

non-tender adenopathy | 1/3: extranodal tissue involvement

Question 50

Leukemia can involve what other organs

Answer 50

liver and spleen

Question 51

what are subcategories of plasma cell neoplasms

Answer 51

multiple myeloma MGUS Plasmacytoma

Question 52

plasma cell neoplasms deal with what cells

Answer 52

B cells

Question 53

plasma cell neoplasms is a problem where and does it include anything else?

Answer 53

arise in bone marrow, rarely involves lymph nodes

Question 54

what do plasma cell neoplasms do to bone

Answer 54

lytic lesions

Question 55

what are the B-symptoms

Answer 55

fever, night sweats, weight loss

Question 56

what do lymphoid neoplasms do to the immune system

Answer 56

disrupt architecture and function of immune system

Question 57

what are two types of lymphomas

Answer 57

Non-hodgkins | Hodgkins