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D&T Exam 1 > Bleeding disorder > Flashcards

Bleeding disorder Flashcards

1
Q

what can give a false low platelet count

A

platelet clumps/fibrin strands

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2
Q

what test is used for primary homeostasis test

A

platelet function analysis

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3
Q

how does platelet function analysis work

A

platelet agonist to interrogate function

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4
Q

what does partial thromboplastin time test

A

intrinsic and common pathway

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5
Q

what does PT prothrombin time test for

A

extrinsic and common pathway

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6
Q

what is the coagulation test results for petechiae and purpura

A

normal

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7
Q

how can drugs damage vessel wall

A

leukocytoclastic vasculitis

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8
Q

scruvy

A

vitamin C deficiency

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9
Q

Ehlers-Danlos syndrome

A

inherited collagen abnormality

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10
Q

Cushing syndome

A

excessive steroid
protein wasting
loss of vascular support

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11
Q

Henoch-Schonlein Purpura

A

systemic hypersensitivity disease in which circulating immune complexes deposit in the vessels

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12
Q

Hereditary Hemorrhagic Telangiectasia

A

dilated tortuous vessels with thin walls

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13
Q

Amyloid infiltration

A

weakens vessel walls

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14
Q

thrombocytopenia

A

deficiency of platelets in blood

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15
Q

at what number does thrombocytopenia a problem

A

less then 50,000

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16
Q

Coagulation test results for someone who is thrombocytopenia

A

normal PT and PTT

platelet count decreased

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17
Q

what is an etiology for thrombocytopenia

A

decreased production bone marrow

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18
Q

what are 2 examples of mechanical damage to platelets

A

prosthetic heart valves

malignant hypertension

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19
Q

immune thrombocytopenic purpura primary

A

idiopathic autoimmune platelet destruction

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20
Q

immune thrombocytopenic purpura secondary

A

identifiable etiology causing autoimmune platelet destruction

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21
Q

what organ contributes to peripheral destruction

A

spleen, splenomegaly

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22
Q

in chronic immune thrombocytopenic purpura what does the peripheral blood show

A

thmobocytopenia with giant platelets reflected by increased MPV

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23
Q

what is the immune’s part in chronic immune thrombocytopenic purpura

A

IgG against platlet antigens, platelet opsonized and removed by spleen

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24
Q

what is the size of the spleen in chronic immune thrombocytopenic purpura

A

normal size

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25
bone marrow for chronic immune thrombocytopenic purpura
INCREASED NUMBER OF MEGAKARYOCYTES WITH LEFT SHIFTED MATURATION
26
acute immune thrombocytopenic purpura preceded by what
viral infections
27
actute immune thrombocytopenic purpura who gets them
kids
28
how long does acuteimmune thrombocytopenic purpura last
6months anything longer becomes chronic
29
Heparin induced thrombocytopenia type I causes what
moderate thrombocytopenia
30
Heparin induced thrombocytopenia type I when does it occur
within a few days of heparin use
31
Heparin induced thrombocytopenia type II when does it start
5-14 days after heparin started
32
where do the antibiotics target in Heparin induced thrombocytopenia type II
against heparin platelet factor 4 complex, activates platelet production
33
what type of thrombosis occurs in Heparin induced thrombocytopenia type II
paradoxical
34
Heparin induced thrombocytopenia type II what must the patient stop taking
Heparin- b/c life threatneing
35
HIV directly infects what
megs because they have CD4
36
what is the classic pentad of clinical findings for thrombotic thrombocytopenic purpura TTP
1. fever 2. thrombocytopenia 3. microangiopathic hemolytic anemia 4. neurologic 5. renal sytmpoms
37
who gets TTP
adults and kids
38
what are the signs and symptoms for hemolytic uremic syndrome (HUS)
1. thrombocytopenia 2. microangiopathic hemolytic anemia 3. acute renal failure
39
who gets HUS
kids more than TTP
40
TTP is a deficiency in what
ADAMTS 13
41
TTP degrades what
HMW mutimers of vWF
42
clinical presentation for HUS
bloody diarrhea | subsequent renal failure
43
HUS is assoicated with what strain
E. Coli strain 0157-H7
44
Bernard-Soulier-Ar
platelet adhesion defects | - Gp Ib deficient
45
Glanzmann's thrombasthenia-AR
platelet aggreation defct | - Gp IIb-IIIa
46
what is the role of Gp Ib complex
where vWF binds
47
results for platelet aggregation test for Bernard-Soulier-Ar
everything works except ristocetin
48
role of Gp IIb-IIIa
where fibrinogen crosslinks platelets
49
results of platelet aggregation test for Glanzmann's thrombasthenia-AR
no aggregation with ADP, Epi, collagen , thrombin
50
type 1 von Willebrand disease
quantative decrease in vWF
51
type 2 von Willebrand disease
qualitative vWF abnormality
52
type 3 von Willebrand disease? what else does it effect
quantitative decrease in vWF affects factor VIII -repalcement therapy
53
Hemophilia A is a deficiency in what
VIII
54
how is hemophilia A inherited
X-linked recessive
55
symptoms for hemophilia A
easy bruising, hemorrhage,
56
factor PTT has prolonged what
PTT
57
hemophilia B is deficient in what
factor IX
58
how is hemophilia B inherited
X-linked recessive
59
what vitamin deficieny cause clotting factor abnormatilites
K
60
DIC
disseminated intravascular coagulopathy
61
mechanism for DIC
tissue factor release into blood - wide spread endothermic cell injury - fibrin deposition in microvasculature - hemorrhagic dithesis
62
DIC can cause what syndrome
waterhouse-Friderchsen syndrome | sheehan syndrome
63
sheehan syndrome
postpartum pituitary necrosis
64
waterhouse-Friderchsen syndrome
massive bilateral adrenal hemorrhage associated with meningococcus
65
coagulation test findings for DIC
prolonged PT, PTT decreaed platelets, fibrinogen increased D-dimer
66
peripheral smear for DIC
schistocytes | left shift

D&T Exam 1 (13 decks)

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