Weight Management Lecture 1 Flashcards

1
Q

t/f obese children have a higher risk of adult obesity

A

treu

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2
Q

what are the 5 A’s of helping with obesity?

A
  1. ask permission to talk about weight
  2. assess their story
  3. advise on management
  4. agree on goals
  5. assist with their drivers and barriers
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3
Q

list 3 reasons people want to lose weight

A
  1. image
  2. health (physical and psychological)
  3. performance
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4
Q

list 5 ways people try to lose weight

A
  1. diet
  2. exercise
  3. medication
  4. surgery
  5. controlling other factors such as stress, energy etc
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5
Q

the cause of obesity is NOT simply ___, but rather the complex interplay of _____

A

inbalance of calories in vs out; multiple genetic factors, metabolic and behavioural and environamnetal factors

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6
Q

how are humans hard-wired against weight loss?

A

decreased food intake and increased physical activity lead to a negative energy balance and trigger cascade of metabolic and neurohormonal adaptive mechanisms

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7
Q

what are the ABC’s of weight couseling?

A

ask permission
build a relationship
critically look for weight bias

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8
Q

what is weight bias?

A

negative attitudes towards others bc of their weight

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9
Q

what is weight stigma?

A

stereotypes and labels we assign to people who have obesity

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10
Q

what is weight stigma?

A

actions against people with obesity that can casue social exclusion and inequities

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11
Q

BMI should serve only as a ___

A

screening measurement

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12
Q

t/f BMI should be used with other information to identify who may benefit from obesity management

A

treu

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13
Q

BMI is the most commonly used objective surrogate marker for

A

body fat

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14
Q

how is BMI calculated ?

A

weight (kg) / height (m2)

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15
Q

1 lb is ____kg

A

2.2

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16
Q

integration of BMI and ____ in clinical assessment may identify the higher risk phenotype of obesity better than either alone, particularly is those with low BMI

A

waist circumference

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17
Q

what is the Edmonton obesity staging system measuring?

A

assessment of risk factors & physical symptoms (risk factors and established co-morbidities) psychological symptoms and physical limitations

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18
Q

does BMI provide information on the distribution of fat?

A

no

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19
Q

body fat in what region is associated with higher prevalence of comorbidities

A

central

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20
Q

wasit circumference should be measured at what stage of breathing?

A

end of normal exhale

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21
Q

cut-off values for waist circumference vary with ___, ___ and ___

A

gender, age, ethnicity

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22
Q

can you have a high BMI and be healthy?

A

yes!

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23
Q

in healthy individuals with a high BMI, is there any evidence to suggest long-term benefits of intentional weight loss? What should the focus be for these individuals?

A

no; focus on healthy lifestyle and not gaining weight

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24
Q

BMI measurements are most useful for what age category?

A

20-65

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25
Q

what 2 adult groups may not be accurately represented by their BMI?

A

those who do a lot of muscle resistance training and those with extreme short/tall stature

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26
Q

is BMI appropriate for infants, children, adolescents, pregnant and breastfeeding women?

A

no

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27
Q

why is BMI not appropriate for adults over 65?

A
  1. not associated with increased mortality in this group

2. being underweight is the greater concern

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28
Q

t/f health canada recommends that diagnosis of obesity not be based off BMI alone

A

true

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29
Q

what are the 3 regions of the brain that regulate weight?

A
  1. hypothalamus
  2. mesolimbic
  3. cognitive lobe
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30
Q

what is the main role of the hypothalamus in weight regulation?

A

energy homeostasis

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31
Q

what is the main role of the mesolimbic in weight regulation?

A

pleasure center, involved in the rewarding aspect of eating

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32
Q

what is the main role of the cognitive lobe in weight regulation?

A

executive functioning (voice of reason) that can override the mesolimbic

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33
Q

when does the cognitive lobe work best in weight regulation and supressing the mesolimbic?

A

under smooth conditions of rest, low stress and support

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34
Q

what is the important goal of therapy for weight management?

A

focus on improved health and wellbeing, not the amount of weight lost

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35
Q

t/f even modest and sustained weight loss is associated with improvements in co-morbidities associated with obesity

A

true

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36
Q

the pathophysiology of obesity is a complex interaction of ___ and ___

A

individual factors and societal factors

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37
Q

list 3 medical conditions that are “organic” causes of weight gain

A
  1. cushings disease
  2. hypothyroidism
  3. endocrinopathies
38
Q

what sort of risk factors are associated with stage 1 obesity? Examples?

A

obesity-related subclinical risk factors ; borderline hypertension, impaired fasting glucose; elevated liver enzymes

39
Q

what type and severity of physical symptoms might be seen in stage 1 obesity?

A

mild (currently not requiring medication for comorbidities); trouble breathing on moderate exertion; occaisional aches and pains

40
Q

what type and severity of psychological symptoms might be seen in stage 1 obesity? How is the quality of life impacted?

A

mild obesity-related physchological symptoms and or mild impairment of well-being. QOL not impacted

41
Q

stage 3 obesity is associated with a sugnificant level of at least 1 of what 4 factors? is quality of life impacted?

A
  1. end-organ damage (heart attack, diabetes complications
  2. obesity-related psychological symptoms
  3. functional limitations
  4. impairment of well-being
    no
42
Q

what is the effect of obesity on leptin?

A

brain gets feeling of chronic low leptin levels

43
Q

what structures in the hypothalamus that increase appetite

A

agouti related peptide and the neuropeptide y

44
Q

what structures in the hyptholamus suppress appetite?

A

pro opimelanocortin (POMP C) and cocaine and amphetamine regulating transcript (CART)

45
Q

ghrelin ____ (raises / lowers) metabolism

A

lowers

46
Q

ghrelin stmilulates what parts of the hypothalamus?

A

the AgPR / NPY (stimulates hunger)

47
Q

release of insulin stimulates what hypothalamus structures? what does it supress?

A

POMC / CART (suppresses appetite); inhibits the AgPR and NPY

48
Q

leptin is released from ___ and stimulates ___ and supresses ___

A

adipose tissue; POMPC and CART ; AgPR and NPY

49
Q

soluble and insoluble fiber promote satiety by ___

A

delaying gastric emptying and causing feeling of fullness

50
Q

glycemic index compares _____ to ingestion of ___g of available carbohydrates from a test food with that of a reference food (glucose or white bread)

A

blood glucose ; 50

51
Q

t/f a higher glycemic index produces more of an insulin spike than lower gylcemic index foods

A

true

52
Q

t/f high-fiber low glycemic index diet results in fewer glycemic spikes

A

treu

53
Q

what is the focus of medical nutrition therapy?

A

individualized eating patterns, food quality and healthy relationship with food

54
Q

t/f medical nutrition therapy includes mindfulness-based eating practices that may help reduce cravings, reduce reward-driven eating, improve body satisfaction and improve awareness of hunger and satiety

A

true

55
Q

t/f medical nutrition therapy assesses for micronutrient deficiencies

A

true

56
Q

what is a negative physiologic impact of very-low calorie diets?

A

may effect neurobiological pathways that control appetite, hunger and cravings. Body weight regulation may result in increased food intake and weight gain

57
Q

what are the risks of a low carb LCD +/- protein diet (keto_

A

increased bone calcium loss, dehydration, gout, kidney and liver disease

58
Q

low fat diets can produce significant weightloss up to ___ years

A

3

59
Q

t/f low fat diets are comparable to reduced energy diets in comparison of weight loss

A

true

60
Q

what is the mediterranean diet?

A

high intake of natural fats, plant foods, moderate intake of fish, poultry, dairy and red wine (low inatke of red meat , eggs and sweets)

61
Q

what is the DASH diet?

A

dietary approach to stop hypertension; emphasizes high intake of fruit, low-fat dairy, veggies, grains, nuts and low intake of red/processed meat and sweets

62
Q

who is considered for weight loss surgury?

A

BMI > 40 or BMI 35-40 with combined high-risk comorbidities

63
Q

what are the 2 main types of weight loss surgury?

A
  1. gastric bypass

2. banded gastroplasty

64
Q

what is gastric bypass?

A

creating a short bowel to produce malabsorption of ingested calories

65
Q

what is banded gastroplasty?

A

a small stomach is created to prevent large caloric intake at any one time

66
Q

which weight loss surgery is associated with greater improvement of weight loss outcomes and better long term outcomes?

A

banded gastroplasty

67
Q

what are some of the complications of weight loss surgery?

A

wound healing, metabolic distrubances, severe diarrhea, bloating, anorectal pain, disruption of drug absorption

68
Q

what is an example of a drug used for weight loss?

A

Bupropion 90mg / Naltrexone 8 mg (Contrave)

69
Q

what BMI may be eligible for Bupropion naltrexone treatment?

A

> 30, 27 with comorbidities

70
Q

what is the usual function of bupropion?

A

inhibits reuptake of DA and NE and causes mild appetite suppression

71
Q

what is naltrexne used for usually?

A

opioid antagonist

72
Q

how is buproprion naltrexone suspected to suppress appetite?

A

by increasing firing of the POMC

73
Q

t/f combination of weight loss mediaction and lifestyle is more successful than lifestyle alone

A

true

74
Q

medications used for weight loss have at least one of the following effects

A
  1. reduce food intake (suppress appetite)
  2. reduce. nutrition absorption
  3. increase enerfy expenditure
75
Q

a ____% reduction in weight is realistic for weight loss medications

A

5-10

76
Q

t/f weight loss requires reduced calories

A

true

77
Q

what is the effect of orlisat of weight loss?

A

inhibits fat absorption by blocking pancreatic lipase, makes oily stools that might make patients want to eat less fat to avoid this

78
Q

what are some notable drug interactions with orlisat?

A
  1. reduction of fat-soluble vitamin absorption
  2. can reduce absorption of synthroid
  3. may affect absorption of oral contraceptives
79
Q

what are some innapropriate mediactions for weight loss?

A

laxatives, syrup of ipecac, diuretics, thermogenic agents

80
Q

who should NOT take bupropion naltrexone?

A

those with uncontrolled high BP, seizures, bulimia, anorexia, opioid use, MAOIs, severe kidney / liver damage

81
Q

is there risk of suicidal thoughts with use of bupropion naltrexone?

A

yes

82
Q

what is a risk of bupropion naltrexone for those with type 2 diabetes?

A

hypogylcemia if pt on glucose lowering treatment

83
Q

what are some adverse effects of bupropion naltrexone?

A

nausea, constipation, dizziness, dry mouth acute glaucoma and headache

84
Q

should bunaltrexone be taken with a high fat meal?

A

no

85
Q

can bunaltrexone be crushed or broken? why /why not?

A

no, risk of seizures

86
Q

what is liraglutide?

A

long-acting analog of human glucagon-like peptide (incretin)

87
Q

what is the function of the liraglutide?

A

stmulates insulin secretion, reduces postprandial glucagon levels, slows gastric emptying and acts on sateiety pathwasy to reduce food inatke

88
Q

who should NOT take liraglutide?

A

if family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2

89
Q

what are some of the adverse effects of liraglutide?

A

nausea, vommiting, upset stomach, gall stones, pancreatitis, increased heart rate, low blood sugar and difficulty sleeping

90
Q

how is liraglutide dosed?

A

SC injection