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1051 PBL > Natural Health Products for Weightloss > Flashcards

Natural Health Products for Weightloss Flashcards

1
Q

what type of NHP causes the most ER visits? In what sex?

A

weight loss; female

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2
Q

weight loss products are promoted for what 5 things?

A
  1. fat burning, increasing thermogenesis or as CNS stimulant
  2. decreasing hunger feelings or increasing fullness
  3. blocking carb?
  4. fat magnet?
  5. nutrient partitioning ?
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3
Q

what is the premise of nutrition partitioning?

A

direct calories to muscle instead to fat

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4
Q

what are 7 common NHPs used in Canada for weight loss?

A
  1. green tea extract
  2. garcinia cambogia
  3. chitosan
  4. conjugated linoleic acid
  5. glucomannan
  6. chromium picolinate
  7. PGX
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5
Q

green tea extract is also known as ____

A

camelia sinensis

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6
Q

t/f green tea extract is the same as drinking a cup of green tea

A

false

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7
Q

what is the indication for green tea extract?

A

to be used in conjunction with reduced calorie intake and increased physical activity to help with weight management

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8
Q

a healthcare provider should be notified if green tea extract is being used for a period of longer than

A

12 weeks

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9
Q

what is the propose MOA for green tea extract?

A

increased thermogenesis

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10
Q

what is the content of a green tea extract supplement?

A

catechols, polyphenols, caffeine

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11
Q

what does the evidence say about the use of green tea extract for weight loss?

A

limited, not clinicallly relevant, amount of weight lost likely to be negliable

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12
Q

what are 2 drug interactions of green tea extract with drugs and what element of the extract is believed to casue?

A
  1. anticoagulants (may have additive anti-platelet effect0
  2. atorvastatin - decrease absorption

Caffeine

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13
Q

the adverse drug reactions to green tea extract are related to the ___ content

A

caffeine

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14
Q

has green tea extract shown instances of being hepatotoxic?

A

yes

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15
Q

Garcinia cambogia is also known as

A

hydroxycitric acid

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16
Q

what is the NHP use of garcinia cambogia?

A

helps body metabolize fats and carbs

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17
Q

a healthcare provider should be consulted for use of garcinia longer than ____

A

6 months

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18
Q

what is the MOA for garcinia?

A

inhibits enzyme that converts citric acid to coenzyme A, thus preventing storage of extra calories as fat

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19
Q

what does the evidence say about the use of garcinia?

A

little or insufficient evidence to support

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20
Q

what is a notable drug interaction for garcinia?

A

drugs that affect serotonin (SSRIS ETC)

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21
Q

what is the stated NHP use of chitosan ?

A

could be a complement to healthy lifestyle that involves reduced calories and regular physical activity

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22
Q

what is the MOA of chitosan?

A

increased excretion of fat

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23
Q

what does the evidence sugest aboyt he use chitosan?

A

insuffiecient, weight loss may be clinallyly irevelunbr

24
Q

what are 2 possible drug interactions with chitosan?

A
  1. acyclovir: reduces absorption

3. anticoaggnulntds: increased effects

25
is chitosan wll-tolerated
true
26
what is the mechanism of action for conjugated linoleic acid?
may impact lipid metabolism and reduce body fat deposits
27
what does the evidence say about linoleic acid for weight loss?
possibly effective, study did find amount of weight lost was not clinically significant
28
what 2 thinsg acn linoleic acid interact with?
1. anticoagulants: additive effect in reducing platelet aggregation 2. antihypertensives: may ne additive (ramipril)
29
what is an ADR that may be experienced with conjugated linoleic acid?
GI upset
30
dietary conjuagted linoleic acid can be found in ___ and ___
milk and beef
31
NHP conjugated linoleic acid is made from
safflower oil
32
a healthcare provider should be consulted is conjugated linoleic acid is used longer than ___
6 months
33
what is Glucomannan?
a water-soluble fiber from that konjac plant
34
what is the NHP use of glucommanan?
no use related to weight loss (lowering cholesterol and as a laxative)
35
a healthcare provider should be informed of glucomannan is being used longer than ___
8 weeks
36
what is the MOA for glucomannan?
swells the stomach, maybe slowing carb absorptions and promoting feeling of fullness
37
what is the evidence around glucomannan an weight loss?
insifficient reliable evidence, one study found that it may reduce weight but not BMI
38
what is chromium picolinate?
formulation to deliver chromium 3
39
what is the NHP use of chromium picolinate?
helps metabolize carbs and fats, provides support of healthy glucose metabolism
40
what is the MOA for the chromium picolinate?
affect brain's hunger receptors and improve insulin sensitivity
41
what is the evidence around the se of chromium piclolinate?
possibly ineffective, no evidence
42
what 2 things can chromium picolinate interact with?
antidiabetic drugs: additive | synthroid: chromium may reduce absorption
43
what are some ADRs associated chromiumpicolinate?
possibly cognitive dysfunction, insomnia, headache and has been associated with renal and liver damge
44
what is PGX?
polyGlycoplaX; a polysaccharide complex from 3 h2O souble fiber, sodium alginate, and xatnthum gunm
45
what is the NHP use of PGX?
he;ps lower glycemic index, reduces appetite by feeling of fullness contributing to healthy blood sugar levels
46
what is the MOA of PGX?
expands in stomach to create feeling of fullness
47
what is the evidence around use of PGX for weight loss?
found to have no significant effects on weight ,
48
give an example of drug interaction with PGX
may reduce abs of absorption (take 1 hr -- 2hrs beore or after )
49
in canada, the sale of ehedrine in sis limuted to what?
1. products for short term use as nasal decongestants
50
in products for short term nasal decongestants, the dose should not exceed _______mg
8; notmore than 32 g /day
51
t/f ephedrine is safe even when combined with other stmulants
fasle
52
t/f ephedrine cant be sold if labeled or implied for weight loss
true
53
what is the Zuccarin diet?
could be a complement to healthy lifestyle that incorporates calorie - reduced diet and regular physical activity
54
what does the Zuccarin supposedly help maintain?
healthy BP, helps support cardio helf, provides antioxigants
55
what is the relationship of the Zuccarin diet blood glucose?
Zuccarin helps maintain body to metabolize carbs and fats (promotes helathy glucose levels)

1051 PBL (10 decks)

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