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1051 PBL > Natural Health Products for Weightloss > Flashcards

Natural Health Products for Weightloss Flashcards

1
Q

what type of NHP causes the most ER visits? In what sex?

A

weight loss; female

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2
Q

weight loss products are promoted for what 5 things?

A
  1. fat burning, increasing thermogenesis or as CNS stimulant
  2. decreasing hunger feelings or increasing fullness
  3. blocking carb?
  4. fat magnet?
  5. nutrient partitioning ?
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3
Q

what is the premise of nutrition partitioning?

A

direct calories to muscle instead to fat

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4
Q

what are 7 common NHPs used in Canada for weight loss?

A
  1. green tea extract
  2. garcinia cambogia
  3. chitosan
  4. conjugated linoleic acid
  5. glucomannan
  6. chromium picolinate
  7. PGX
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5
Q

green tea extract is also known as ____

A

camelia sinensis

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6
Q

t/f green tea extract is the same as drinking a cup of green tea

A

false

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7
Q

what is the indication for green tea extract?

A

to be used in conjunction with reduced calorie intake and increased physical activity to help with weight management

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8
Q

a healthcare provider should be notified if green tea extract is being used for a period of longer than

A

12 weeks

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9
Q

what is the propose MOA for green tea extract?

A

increased thermogenesis

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10
Q

what is the content of a green tea extract supplement?

A

catechols, polyphenols, caffeine

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11
Q

what does the evidence say about the use of green tea extract for weight loss?

A

limited, not clinicallly relevant, amount of weight lost likely to be negliable

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12
Q

what are 2 drug interactions of green tea extract with drugs and what element of the extract is believed to casue?

A
  1. anticoagulants (may have additive anti-platelet effect0
  2. atorvastatin - decrease absorption

Caffeine

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13
Q

the adverse drug reactions to green tea extract are related to the ___ content

A

caffeine

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14
Q

has green tea extract shown instances of being hepatotoxic?

A

yes

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15
Q

Garcinia cambogia is also known as

A

hydroxycitric acid

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16
Q

what is the NHP use of garcinia cambogia?

A

helps body metabolize fats and carbs

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17
Q

a healthcare provider should be consulted for use of garcinia longer than ____

A

6 months

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18
Q

what is the MOA for garcinia?

A

inhibits enzyme that converts citric acid to coenzyme A, thus preventing storage of extra calories as fat

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19
Q

what does the evidence say about the use of garcinia?

A

little or insufficient evidence to support

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20
Q

what is a notable drug interaction for garcinia?

A

drugs that affect serotonin (SSRIS ETC)

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21
Q

what is the stated NHP use of chitosan ?

A

could be a complement to healthy lifestyle that involves reduced calories and regular physical activity

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22
Q

what is the MOA of chitosan?

A

increased excretion of fat

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23
Q

what does the evidence sugest aboyt he use chitosan?

A

insuffiecient, weight loss may be clinallyly irevelunbr

24
Q

what are 2 possible drug interactions with chitosan?

A
  1. acyclovir: reduces absorption

3. anticoaggnulntds: increased effects

25
Q

is chitosan wll-tolerated

A

true

26
Q

what is the mechanism of action for conjugated linoleic acid?

A

may impact lipid metabolism and reduce body fat deposits

27
Q

what does the evidence say about linoleic acid for weight loss?

A

possibly effective, study did find amount of weight lost was not clinically significant

28
Q

what 2 thinsg acn linoleic acid interact with?

A
  1. anticoagulants: additive effect in reducing platelet aggregation
  2. antihypertensives: may ne additive (ramipril)
29
Q

what is an ADR that may be experienced with conjugated linoleic acid?

A

GI upset

30
Q

dietary conjuagted linoleic acid can be found in ___ and ___

A

milk and beef

31
Q

NHP conjugated linoleic acid is made from

A

safflower oil

32
Q

a healthcare provider should be consulted is conjugated linoleic acid is used longer than ___

A

6 months

33
Q

what is Glucomannan?

A

a water-soluble fiber from that konjac plant

34
Q

what is the NHP use of glucommanan?

A

no use related to weight loss (lowering cholesterol and as a laxative)

35
Q

a healthcare provider should be informed of glucomannan is being used longer than ___

A

8 weeks

36
Q

what is the MOA for glucomannan?

A

swells the stomach, maybe slowing carb absorptions and promoting feeling of fullness

37
Q

what is the evidence around glucomannan an weight loss?

A

insifficient reliable evidence, one study found that it may reduce weight but not BMI

38
Q

what is chromium picolinate?

A

formulation to deliver chromium 3

39
Q

what is the NHP use of chromium picolinate?

A

helps metabolize carbs and fats, provides support of healthy glucose metabolism

40
Q

what is the MOA for the chromium picolinate?

A

affect brain’s hunger receptors and improve insulin sensitivity

41
Q

what is the evidence around the se of chromium piclolinate?

A

possibly ineffective, no evidence

42
Q

what 2 things can chromium picolinate interact with?

A

antidiabetic drugs: additive

synthroid: chromium may reduce absorption

43
Q

what are some ADRs associated chromiumpicolinate?

A

possibly cognitive dysfunction, insomnia, headache and has been associated with renal and liver damge

44
Q

what is PGX?

A

polyGlycoplaX; a polysaccharide complex from 3 h2O souble fiber, sodium alginate, and xatnthum gunm

45
Q

what is the NHP use of PGX?

A

he;ps lower glycemic index, reduces appetite by feeling of fullness contributing to healthy blood sugar levels

46
Q

what is the MOA of PGX?

A

expands in stomach to create feeling of fullness

47
Q

what is the evidence around use of PGX for weight loss?

A

found to have no significant effects on weight ,

48
Q

give an example of drug interaction with PGX

A

may reduce abs of absorption (take 1 hr – 2hrs beore or after )

49
Q

in canada, the sale of ehedrine in sis limuted to what?

A
  1. products for short term use as nasal decongestants
50
Q

in products for short term nasal decongestants, the dose should not exceed _______mg

A

8; notmore than 32 g /day

51
Q

t/f ephedrine is safe even when combined with other stmulants

A

fasle

52
Q

t/f ephedrine cant be sold if labeled or implied for weight loss

A

true

53
Q

what is the Zuccarin diet?

A

could be a complement to healthy lifestyle that incorporates calorie - reduced diet and regular physical activity

54
Q

what does the Zuccarin supposedly help maintain?

A

healthy BP, helps support cardio helf, provides antioxigants

55
Q

what is the relationship of the Zuccarin diet blood glucose?

A

Zuccarin helps maintain body to metabolize carbs and fats (promotes helathy glucose levels)

1051 PBL (10 decks)

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