week13 Flashcards
GSE LMN motor unit consists of
neuron cell body ventral root of spinal nerve spinal/peripheral nerve of cranial nerve skeletal muscle cell NMJ
the LMN NMJ must be working properly, this includes
release of Ach, normal ACh receptor,
diseases that affect the NMJ are commonly called
junctionopathies
Diffuse neruomuscular disease affects
most of the LMN motor units
many diffuse neuromuscular diseases imitate
one another
in diffuse neuromuscular disease, mentation is
usually normal
posture of NMD
may be anywhere from ambulatory to recumbent
ambulatory animals will typically be
paretic; hae difficulty supporting their trunk and head; (heavy heads); exercise may worsen paresis
tone in NMD
hypotonic
gait
if ambulatory, typically short and choppyw ithout ataxia; (no proprioceptive deficits)
when sciatic nerve affected and femoral is not
animals will have exaggerated gait in pelvic limbs; plantgrade; (normal femoral nerve with lack of innervation to caudal thigh muscles to act as antagonist)
postural responses
no sensory involvement in pure NMD, so no deficits; however may be too weak to perform reflexes/responses
spinal reflexes
usually hyporeflexia to areflexia
cranial nerves
cranial nerves that contain GSE LMNs
cranial nerve sings in NMD
difficulty chewing dysphagia dysphonia inspiratory stridor megaesophagus regurgitation facial pralysis laryngeal pralysis
