Week Two (Part Three) Flashcards
Acute Hepatitis
Causes:
Drugs, chemical, toxin
Parasite
Bacteria
Virus
Acute Hepatitis
Mechanism (Pathology):
Hepatotropic viral infection damages the liver through direct cellular unjury or induction of immune response
Acute Hepatitis
Clinical Manifestations (Phase(s)):
Incubation Period
Preicterus or Prodromal Phase
Icteric Phase
Convalescent Phase
Acute Hepatitis
Preicterus or Prodromal Phase
Clinical Manifestations:
Flu-like symptoms GI distress Right flank pain Distaste for smoking in smokers AST, ALT, bilirubin increase
Acute Hepatitis
Incubation Period
Clinical Manifestations:
No manifestations, varies according to type of virus.
Acute Hepatitis
Clinical Manifestations:
Ranges from asymptomatic (without jaundice), to fulminant (severe and sudden onset).
Acute Hepatitis
Icteric Phase
Clinical Manifestations:
5- 10 Days after the Preicteric Phase
Jaundice Dark Yellow Urine Severe Pruritis Hepatosplenomegaly AST, ALT, bilirubin increase
Acute Hepatitis
Convalescent Phase
Clinical Manifestations:
Gradual increase in sense of well-being. Return of appetite, disappearance of jaundice.
Acute Hepatitis
Clinical Course and Complications (List):
Fulminant Hepatitis
Chronic Persistent Hepatitis
Chronic Active Hepatitis
Chronic Carrier
Acute Hepatitis
Clinical Course and Complications
Fulminant Hepatitis
Agents: HBV, HCV, HDV
Prognostic: Fatal (90- 100%)
Acute Hepatitis
Clinical Course and Complications
Chronic Persistent Hepatitis (Agents & Prognostic)
Criteria: Elevated AST, ALT for >6 months
Agents: HBV, HCV
Prognostic: Benign
Acute Hepatitis
Clinical Course and Complications
Chronic Active Hepatitis (Agents & Prognostic)
Criteria: Elevated AST, ALT for >6 months
Agents: HBV, HCV
Prognostic: Poor
Acute Hepatitis
Clinical Course and Complications Chronic Carrier (Agents & Prognostic)
Agents: HBV, HCV
Prognostic: Increased risk of hepatoma
Acute Hepatitis
Prevention
HAV:
Washing hands
Vaccination (passive, active)
Acute Hepatitis
Prevention
HBV:
Hygiene Vaccination (passive, active)