Week Four Flashcards
Growth Hormone Disorders Growth Hormone (Somatotropin)
Effects:
Promote linear bone growth, growth of visceral and endocrine organs, muscle, skin, connective tissue.
Improve rate of protein synthesis
Enhance mobilization of F.A.
Increase blood sugar level by decreasing its use
Growth Hormone Disorders Growth Hormone (Somatotropin)
Mechanism (Pathology):
Many of the effects of Growth Hormone depend on Somatomedin (produced by the liver).
Growth Hormone Disorders Growth Hormone (Somatotropin)
Regulation:
Somatostatin inhibits production
GH-RH stimulates its production
Production peaks 3-4 hours after onset of sleep
Secretion is stimulated by hypoglycemia, starving, increased blood amino acids, physical and emotional stresses.
Growth Hormone Disorders
Short Stature
Causes:
Genetic Chromosomal Chronic illness, Malnutrition, Malabsorption Endocrine Psychosocial
Growth Hormone Disorders
Short Stature
Classification (Causal):
Idiopathic GH deficiency
Pituitary agenesis or tumor
Panhypopituitarism
Growth Hormone Disorders
Short Stature
Classification (Onset):
Congenital
Acquired
Growth Hormone Disorders
Short Stature
Manifestations:
Congenital Growth Hormone deficiency is associated with normal birth length, followed by a decrease in growth rate that can be identified by careful measurement during the 1st year (and becomes obvious by the 1st and 2nd years of age).
Delayed skeletal maturation, puberty
Neonate with Growth Hormone deficiency can have a seizure due to hypoglycemia.
Growth Hormone Disorders
Tall Stature
Causes:
Genetic
Endocrine
Growth Hormone Disorders
Tall Stature
Manifestations:
Onset during childhood- Gigantism Onset during adulthood (slow onset)- Acromegaly Glucose intolerance => Diabetes Cardiomegaly => High Blood Pressure Hyperostosis =>Neuropathy Goiter => Intolerance to heat Headache Compression II => Visual field defect Hypogonadisn => low libido, disturbed menses
Growth Hormone Disorders
Tall Stature
Lab Tests:
Elevated Growth Hormone not suppressed by a glucose load.
