Week Nine (Regulation) Flashcards
Prokaryotic regulators
Operons
Histone accetlyation
Loosen chromatin structure promoting initiation of transcription
DNA methylation
Condenses chromatin (reducing transcription)
Control elements
Noncoding DNA serve as transcription binding sites (interaction with transcription factors)
Transcription factors inhibiting
Act as repressors directly or indirectly (influencing chromatin structure)
Post transcriptional regulation
Fine tune gene expression as response to environment
RNA processing
Alternative splicing (different mRNA from same primary transcript)
Blocking initiation of translation
Regulatory proteins bind to RNA
mRNA degradation
Lifespan of mRNA
Protein degradation
Cells mark protein with ubiquitin which is recognized by proteosome
Noncoding (rRNAs and tRNAs)
Parts of genome transferred to these regions regulating gene expression at translation and chromatin configuration
MicroRNAs
Degrade mRNA or block translation
Small interferring RNA
Inhibit gene expression