Week 9 - Pulmonary Flashcards
Decongestant MOA
bind to alpha 1 adrenergic agonist (turn on SNS) which causes vasoconstriction
Decongestant AE
headache, dizziness, nervousness, nausea, CV irregularities (mimic effects of increased SNS activity)
what are antitussives?
cough suppressive, best used for dry cough
antitussive MOA
decrease afferent nerve activity or decrease cough center sensitivity
what are -terol
inhaled beta agonists
-terol MOA
agonize B2 receptors in lung which cause bronchodilation
-terol AE
generally well tolerated; fairly selective can cause tachycardia, tremor, hypokalemia
inhaled antimuscarinics (anticholinergics) MOA
primarily bind to M3 in airway smooth muscle which antagonizes ACh which causes bronchodilation
Anticholinergics AE
generally well tolerated, dry mouth
inhaled corticosteroids typically end in what suffux?
-asone
Inhaled corticosteroids AE
oral candidiasis (yeast in the mouth), hoarse voice, bruising, increased risk of pneumonia, osteoporosis and cataracts in elderly
do you want to use inhaled corticosteroids long term?
no
montelukast (SIngular) MOA
(competitive antagonist) binds to leukotriene receptors to block action
omalizumab (Xolair) MOA
(competitive antagonist) bind to IgE antibody which is produced during allergen reaction
Omalizumab (Xolair) AE
injection side reaction
How many treatments of albuterol can be used before medical help?
3 treatments within 20 minutes
Cystic Fibrosis Transmembrane Regulator (CFTR) MOA
improve CFTR activity (chloride channels open longer to improve transport) - improved regulation of Na2+ and H2O to thin mucous
CFTR AE
headache, GI issues (NVD), respiratory issues, dizziness, hypertension
