Week 6 - Autonomic Nervous System Flashcards
What are the catecholamine neurotransmitters?
dopamine
epinephrine
norepinephrine
preganglionic neurons release what neurotransmitter and bind to what type of receptor?
Ach that binds to nicotinic receptors on postganglionic cell
All parasympathetic postganglionic neurons release what neurotransmitter and bind to what type of receptor?
Ach that binds to cholinergic receptors
Most sympathetic postganglionic neurons release what neurotransmitter and bind to what receptors?
NE that binds to various receptors
What are AE of anticholinergic drug?
can’t see, can’t spit, can’t pee, can’t poop
Patients with what issues should avoid anticholinergic drugs?
patients w/ history of urinary retention and/or narrow angle closure glaucoma
What does atropine do?
decrease saliva and secretions
What is MOA of anticholinergic drugs for overactive bladder?
antagonize muscarinic receptors on bladder smooth muscle to decrease contraction
Why do you want to avoid anticholinergics in older adults?
can make cognitive issues worse
What type of drug would you use to treat glaucoma
cholinergic (remember anticholinergic is can’t see so cholinergic would be opposite)
What type of drug would you use to treat urinary retention?
cholinergic
Why is a cholinergic drug a good treatment for Alzheimer’s?
because Alzheimer’s is associated with decreased levels of Ach and cholinergic drugs indirectly act to block breakdown of Ach
What do direct acting cholinergic drugs do?
act on muscarinic receptors (act directly on the receptors)
What do indirect acting cholinergic drugs do?
inhibit AchE (acetylcholinesterase) which breaks down Ach - block breakdown of Ach so it can be reabsorbed
What are cholinergic AE’s?
SLUDGE
Sweating Lacrimation Urination Diarrhea GI cramping Emesis (vomiting)
