Week 9 Lecture 9 - bipolar disorder Flashcards
What is the Mood Disorder Questionnaire?
a self-report inventory that screens for
a lifetime history of (hypo)manic experiences
What did a study by Udachina, A., & Mansell, W. (2007) investigating Self-reported History of Hypomanic Symptoms
in a Student Population find?
most students had experienced at least 1 symptom of hypomania
What are the characterisations of mood episodes in bipolar disorder?
- The mood episode is associated with an unequivocal change in functioning that is uncharacteristic of the person when not symptomatic
- The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
- The disturbance in mood and change in functioning is observable by others
What are the symptoms of major depression?
At least 2 weeks of:
-Depressed mood
and / or
-Markedly diminished interest or pleasure in activities
Plus at least three symptoms:
-Significant change in appetite or weight
-Insomnia or hypersomnia
-Psychomotor agitation / retardation
-Fatigue or loss of energy
-Feelings of worthlessness and/or inappropriate guilt
-Diminished ability to think or concentrate
-Recurrent thoughts of death, suicidal ideation, suicide attempt, or a specific plan for committing suicide
What are the symptoms of mania and hypomania?
Mania (at least 1 week )
Hypomania (at least 4 days) of:
- abnormally + persistently elevated, expansive or irritable mood
and
- abnormally & persistently increased activity or energy
Plus at least three or more of:
- Inflated self esteem / grandiosity
- Decreased need for sleep
- More talkative than usual, pressure of speech
- Flight of ideas, thoughts racing
- Distractibility
- Increased in goal-directed activity
- Excessive involvement in pleasurable activities - may have high potential for painful consequences
Mania must lead to marked impairment in social or occupational functioning, hospitalisation, or psychosis
What are some predictors of relapse in mood disorders?
- Stressful interpersonal life events
-High ‘Expressed Emotion’ (hostility, overprotectiveness, criticism) in family members
-Disrupted social rhythm events including
sleep changes
*Goal-attainment Events *manic symptoms and not depression
What is cyclothymia?
For at least 2 years:
- numerous periods of hypomanic
symptoms not meeting threshold for
hypomanic episodes
- Numerous periods of depressed mood /
loss of interest that do not meet depression
The symptoms cause clinically significant
distress or impairment in:
- Social
- Occupational
- Or other important areas of functioning
What are the different types of other specified bipolar disorder?
- Short-duration hypomanic like episodes (2-3 days) and major depressive episodes
- Hypomanic-like episodes with insufficient
symptoms and major depressive episodes - Hypomanic episodes without prior major
depressive episode(s) - Short-duration cyclothymia
- Short-duration manic-like episodes
- Unable to determine whether bipolar or
related disorder is primary - Other (describe)
- Unspecified
What is the Bipolar at Risk (BAR) criteria?
Standardised Bipolar At Risk (BAR) criteria developed by Bechdolf & colleagues (2010):
- Youth (15-25) experiencing:
- Short duration high mood
- Short duration high & low mood
- First degree relative with BD plus low mood
What did early detection of BD focus on?
familial risk and identification of state-trait factors
Does BAR criteria have predictive validity?
yes
Can BAR criteria be used to reliably assess someone in an NHS context?
yes
Does BAR criteria hold clinical utility?
yes
What is the importance of early identification in BD?
- Bipolar disorder affects 1-3% of the population
- Average duration of untreated illness (DUI) is 6-10 years, or longer for onset in adolescence
-Longer DUI is associated with more mood
episodes & higher risks of suicide
-Economic impact of Bipolar Disorder in the UK is projected to be £8.2 billion by 2026
What are some biological factors of mood disorders that should be taken into account?
- high heritability
- separate heritability of mania and depression
- genes for mania may involve reward pathways i.e., dopamine function