Week 9? Flashcards
Why are fungal cells more complex than bacterial cells?
Contains a nucleus and more internal cell structures
antimicrobials role
stops the spread of a disease
As Fungal cells are microbial targets, how do they achieve minimal damage to human cells?
Through selective toxicity
Amphotericin role
Targets erogesterol in fungal membrane by binding to it to cause leaks, used during fungal infections
Nystatin role
Targets erogestrol by attacking membrane, used for topical infections
Azoles role
Targets produciton of erogestrol by inhibiting lanestrol 14a - demethylase
How do viruses reproduce?
Hijack host cells to produce genetic material
How does Herpes reproduce
Targets viral DNA polymerase, to stop it Acylovir is used which stops the polymerase
How does Hepatitis C reproduce
Targets RNA polymerase, stopped by using sofobuvir by blocking rna production
How does influenza reproduce
Targets neuramindase, uses oseltamivir which stops viral release
How does HIV reproduce
Reverse transcriptase, stopped by zidovudine by stopping reverse transcription
Purine and Pyrimidine Analogues (Nucleoside Analogues) and why they are species specific
Pretends to be natural AA which becomes part of DNA chain,
Causes termination in the chain
SS because they bind to viral enzymes
Non-Nucleoside Inhibitors of Reverse Transcriptase (NNRTIs)
Binds to a site on HIV reverse transcriptase, SS because no equivalent cells like it
Direct Inhibitors of DNA Polymerase and Reverse Transcriptase
Protease inhibitors
Inhibits HIV protease enzyme , SS because HIV protease not found in humans making it suitable for selective toxicity
