Week 4 Viruses Y Flashcards
Viruses definition
Viruses are simple, acellular entities of one or
more molecules of DNA or RNA enclosed in a
coat of protein (lipids or carbohydrates). They can
only reproduce within living cells.
Name the different viral shapes
icosahedral - 20 triangular faces
helical-flexible cylinders
Enveloped
Complex - icosahedral head and helical tail
Viruses have
Have simple acellular organization
Have either DNA or RNA not both
Inability to reproduce independently
How to isolate viruses
Centrifugation
Precipitation
Denaturation
Enzymatic denaturation
Acute infections
Short duration
■ Host normally develops long-lasting immunity
How an animal virus replicates
Glycoprotein spikes of the virus bind to cell receptor, it is then engulfed (endocytosis),
Nucleic acid released from capid this is its dna
dna enters nucleus and inserts itself into the genome
replicates and releases new virus to repeat
Bacteriophage
Viruses that infect bacteria
Describe the appearance of bacteriophage
Capsid head containing DNA, Healical sheath as a neck, Hexagonal base plate, tail fibres as legs
Types of bacteriophage
virulent
temperate
Lytic cycle
ruptures cell
Lysogenic cycle
Instead of
destroying host to produce virus progeny,
the viral genome remains within the host
cell and replicates with the bacterial
chromosome.
Holin
enzyme which destabilizes the host cell membrane
(pokes holes)
Lysin / lysozymes
phage enzyme which breaks host cell
wall (lyses host bacteria)
Lysogeny
WHEN A VIRUS INTEGRATE WITH THE CELL’S
GENOME.
Viroids
Smallest known infectious pathogens, made up of a short strand of circular rna, mostly causes plant diseases