Week 8 BG Disorders and Diff Dx From PD

Question 1

what is normal pressure hydrocephalus (NPH)

Answer 1

older adults, 60+, slowly developing, slow enlargement of ventricles and reversible. Gait disturbances, urinary incontinence, dementia/cognition decline

Question 2

What are some Parkinson’s plus syndromes and what are some characteristics

Answer 2

• progressive supra nuclear palsy (PSP)
• Multiple system atrophy
• don’t usually respond L-dopa (which is something that people with PD respond to).

Question 3

what is progressive supra nuclear palsy (PSP)

Answer 3

bradykinesia, unstable gait with frequent falls, rigidity, vertical gaze palsy, cognitive impairments and more rapid progression

Question 4

what is multiple system atrophy (MSA)

Answer 4

degeneration affecting the cortex and cerebellum as well as the BG that leads to
bradykinesia, rigidity, wide BOS, frontal lobe dysfunction, ANS dysfunction, shy-draper syndrome, striatonigral Degeneration and olivopontocerebellar atrophy

Question 5

how can we differentiate MSA with PD

Answer 5

MSA has a wide BOS, and usually, in PD you have a small BOS

Question 6

what is HD

Answer 6

huntington’s: generation of the BG, autosomal dominant trait, affecting 6.5/100,000
progressive, manifests by 30 years old and die within 15-25 years.

Question 7

what are the motor HD symptoms

Answer 7

jerky movements, chorea, gait similar to PD, decreased cadence and wide BOS, postural issues like PD

Question 8

what are the cognitive and behavioral symptoms of HD

Answer 8

dementia, memory loss, impaired judgement, personality changes.

Question 9

HD prognosis

Answer 9

early signs of clumsiness, incoordination and jerkiness, and dementia and psychological dysfunction follows, then completely bed bound.