Week 7 - Systemic Lupus Erythematosus Flashcards
what is systemic lupus erythematosus
- chronic, multisystem inflammatory disease of autoimmune origin
what causes systemic lupus erythematosus (SLE) (4)
interactions among
- genetic
- enviro
- immunological
- hormonal factors
who does SLE effect more
- 10x more common in females than males
what is SLE characterized by (3)
- variability within and among persons
- chronic, unpredictable course
- marked w alternating periods of exacerbations and remissions
describe the symptoms of SLE (4)
- variable
- range from relatively mild to rapidly progressive
- no characteristic pattern
- any organ can be impacted
what tissues are most commonly effected by SLE (6)
- skin
- muscle
- lungs
- heart
- nervous tissue
- kidneys
what are the generalized complaints of SLE (5)
- fever
- weight loss
- arthralgia
- excessive fatigue
- pain
what are the dermatological manifestations of SLE(7)
- cutaneous vascular lesions
- butterfly rash on cheeks and bridge of nose
- discoid –> round, coin shaped lesions
- photosensitivity
- ulcers of oral or nasopharyngeal membranes
- alopecia
- dry, scaly scalp
what are the musculoskeletal manifestations of SLE (4)
- polyarthalgia with morning stiffness
- diffuse swelling
- joint and muscle pain
- increased risk of bone loss & fracture
what cardiopulmonary manifestations are associated w SLE (4)
- tachypnea
- cough
- dysrhythmias
- pleurisy & pleural effusion
what renal problems are associated w SLE (3)
- lupus nephritis
- mild proteinuria
- rapid, progressive glomerulonephritis
what nervous system manifestations are associated w SLE (7)
- generalized or focal seizures
- disorientation
- memory deficits
- psychiatric symptoms
- depression
- psychosis
- HA
what hematological manifestations are associated with SLE (4)
- anemia
- leukopenia
- thrombocytopenia
- coagulopathy –> either excessive bleeding or bloof clot formation
describe the relationship between SLE and infections
- causes increased susceptibility to infections
- infection is a major cause of death
which two symptoms are most commonly reported by pts to interfere w their QOL
- pain
- fatigue