Week 7 - Systemic Lupus Erythematosus Flashcards

1
Q

what is systemic lupus erythematosus

A
  • chronic, multisystem inflammatory disease of autoimmune origin
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2
Q

what causes systemic lupus erythematosus (SLE) (4)

A

interactions among

  • genetic
  • enviro
  • immunological
  • hormonal factors
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3
Q

who does SLE effect more

A
  • 10x more common in females than males
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4
Q

what is SLE characterized by (3)

A
  • variability within and among persons
  • chronic, unpredictable course
  • marked w alternating periods of exacerbations and remissions
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5
Q

describe the symptoms of SLE (4)

A
  • variable
  • range from relatively mild to rapidly progressive
  • no characteristic pattern
  • any organ can be impacted
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6
Q

what tissues are most commonly effected by SLE (6)

A
  • skin
  • muscle
  • lungs
  • heart
  • nervous tissue
  • kidneys
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7
Q

what are the generalized complaints of SLE (5)

A
  • fever
  • weight loss
  • arthralgia
  • excessive fatigue
  • pain
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8
Q

what are the dermatological manifestations of SLE(7)

A
  • cutaneous vascular lesions
  • butterfly rash on cheeks and bridge of nose
  • discoid –> round, coin shaped lesions
  • photosensitivity
  • ulcers of oral or nasopharyngeal membranes
  • alopecia
  • dry, scaly scalp
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9
Q

what are the musculoskeletal manifestations of SLE (4)

A
  • polyarthalgia with morning stiffness
  • diffuse swelling
  • joint and muscle pain
  • increased risk of bone loss & fracture
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10
Q

what cardiopulmonary manifestations are associated w SLE (4)

A
  • tachypnea
  • cough
  • dysrhythmias
  • pleurisy & pleural effusion
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11
Q

what renal problems are associated w SLE (3)

A
  • lupus nephritis
  • mild proteinuria
  • rapid, progressive glomerulonephritis
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12
Q

what nervous system manifestations are associated w SLE (7)

A
  • generalized or focal seizures
  • disorientation
  • memory deficits
  • psychiatric symptoms
  • depression
  • psychosis
  • HA
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13
Q

what hematological manifestations are associated with SLE (4)

A
  • anemia
  • leukopenia
  • thrombocytopenia
  • coagulopathy –> either excessive bleeding or bloof clot formation
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14
Q

describe the relationship between SLE and infections

A
  • causes increased susceptibility to infections

- infection is a major cause of death

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15
Q

which two symptoms are most commonly reported by pts to interfere w their QOL

A
  • pain

- fatigue

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16
Q

what is a major challenge in treating SLE

A
  • managing the acute phase while preventing complications of treatment that cause long-term tissue damage
17
Q

what is included in collaborative care for SLE

A
  • meds
18
Q

describe an exacerbation of SLE

A
  • during an acute exac, the pt can become abruptly and dramatically ill
  • may need to be admitted to hospital
19
Q

what should you assess/monitor for during an acute exac of SLE (10)

A
  • S&S of infection
  • I&O
  • joint inflammation
  • signs of AKI
  • collect 24-hr urine samples for creatinine clearance and protein
  • signs of bleeding
  • neuro assessment
  • extreme fatigue
  • document the response to therapy
  • peripheral neuropathy
  • limitation of motion
  • location and degree of pain/discomfort
20
Q

what are some meds included in treatment for SLE (5)

A
  • NSAIDs for mild disease
  • corticosteroids for exacerbation and severe disease
  • immunosuppressive meds
  • steroid-sparing meds
  • antimalarials
21
Q

what should be included in the teaching plan for a pt with SLE & the caregiver (12)

A
  • disease process
  • med education
  • pain mngmt strategies
  • energy conservation & pacing techniques
  • therapeutic exercise
  • use of heat therapy for arthralgia
  • avoid physical & emotional stress
  • avoid exposure to individuals w infection
  • avoid drying soaps, powders, household chems
  • use sunscreen protection
  • regular med & lab follow ups
  • community resources and health care agencies
22
Q

what is imp to teach pts regarding the disease process

A
  • even strong adherence to the treatment plan cannpy guarantee against exac bc the course of the disease is unpredictable
23
Q

what factors increase disease activity (6)

A
  • fatigue
  • sun exposure
  • emotional stress
  • infection
  • drugs
  • surgery
24
Q

describe the relationship between SLE and pregnancy

A
  • pregnancy should be planned when disease activity is minimal
25
Q

describe the psychosocial impact of SLE (2)

A
  • skin rashes, discoid lesions and alopecia can contribute to social isolation
  • pain & fatigue interfere w QOL