Week 11 - Breast Cancer Flashcards
what things occur w cancer cells (5)
- poor differentiated
- uncontrolled & unregulated growth of cells
- cells are abnormal
- invade and infiltrate other tissues (metastasis)
- can recur (after remission)
the diagnosis of cancer is focused on (7)
- health history (carcinogens)
- family history
- physical exam
- CXR
- CT
- blood work
- biopsy
what is the most definitive diagnostic test for breast cancer
- biopsy
treatment options for cancer are based on..
-biopsy results –> cancer staging
what is the goal of cancer treatment (3)
- cure
- control
- palliation
how is cancer cured & controlled (3)
- surgery to remove or debulk tumour
- chemo
- radiation
can be a combo
what is the goal of supportive & palliative care for cancer
- goal is to relieve or control symptoms
- optimize QOL
what are some examples of supportive & palliative care for pts w cancer (3)
- colostomy to prevent bowel obstruction
- laminectomy to relieve spinal cord compression
- debulking of tumor, radiation, chemo to relieve pain or pressure
what are some risk factors for breast cancer (8)
- age 50 or older
- personal history
- family history
- alcohol intake
- sedentary lifestyle
- weight gain during adulthood
- dietary fat intake
- exposure to ionizing radiation
what are symptoms of breast cancer (5)
- hard, irregular shaped lump that is nonmobile & nontender
- clear or bloody nipple discharge
- nipple retraction
- dimpling/pulling in of skin
- possible rash or skin changes
what is the main complication of breast cancer
- recurrence that can be local/regional near the masectomy site or distant
what is included in diagnostic studies for breast cancer (5)
- mammography
- MRI
- physical exam
- US
- biopsy
what is the treatment for breast cancer
- directed by stage and type
- surgery = primary
- combined w drug therapy, chemo, and radiation
what are different types of surgeries for treatment of breast cancer (5)
- lumpectomy
- radical mastectomy
- axillary node dissection (ALND)
- modified radical mastectomy
- sentinal lymph node dissection (SLND)
what is a lumpectomy
- breast conserving surgery
- removal of the entire tumour along w a marigin of normal surrounding tissue
- may also remove some lymph nodes
what is required post-lumpectomy
- radiation to the entire breast + a boost to the tumour bed
what are contraindications to a lumpectomy (4)
- breast too small in relation to tumour size
- masses in more than one quadrant
- masses in the same breast quadrant
- central location of the tumour near the nipple
what is the goal of a lumpectomy
- maximize cancer treatment and cosmetic outcome w minimal risk
what is the benefit to a lumpectomy
- the breast and nipple and preserved
what may make a mastectomy a better option over a lumpectomy (2)
- contraindications to radiation therapy –> ex. active lupus, prior radiation therapy in the radiation field
- contraindications to lumpectomy (as previously discussed)
what are disadvantages to a lumpectomy (2)
- increased cost of surgery + radiation over surgery alone
- possible s/e of irradation
what is a modified radical mastectomy
- removal of the breast and axillary nodes
- spares the pectoralis major muscle
when is a modified radical mastectomy preferred over lumpectomy
- if tumour is too large to excise w adequate margina
- if tumour is so large it will produce a poor cosmetic result
what is a radical mastectomy
- removal of the entire breat, entire chest wall, and all nodes (not often done)