Week 7 - RA

Question 1

Osteoarthritis

Answer 1

Chronic, degenerative synovial joint condition characterized by loss of articular cartilage

abnormal load mechanical factors which affect loading and wear

transmission of inflammatory mediators from the synovial fluids into the cartilage causing inflammatory reactions and subsequent damage

chondrocytes attempt repair but there is excessive enzymatic cartilage degradation that leads to progressive chondrocyte death and cartilage destruction = subchondral bone becomes involved in the process

bone undergoes infarction in places forming bone cysts

attempts at repair = subchondral sclerosis and marginal osteophytes

synovium and periarticular ST become inflamed = joint looses mobility and function

Question 2

Primary OA

Answer 2

no discernible or identifable aetiology

Question 3

Secondary OA

Answer 3

where etiology can be identified

Question 4

Ra patho

Answer 4

progressive, autoimmune disease.

occurs when there is a interaction between genetic and environmental risk factors of RA

antibodies flow into the synovial joint via the blood circulation, stimulate leucocyte proliferation.

Infliltration of the synovium with T-lympocytes and macropphages then release

Question 5

Gout

Answer 5

inflammatory metabolic condition that occurs when a patient has a purine rich diet which leads to higher hyperuricemia

this results in decreased renal urate excretion and hence increased urate production which then results in monosodium urate crystals forming which then leads to the painful onset of a gout attack