Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PATHO/PHARM I > Week 6 Lecture ppt > Flashcards

Week 6 Lecture ppt Flashcards

1
Q

The heart is composed of what:

A

The heart is composed of two conjoined pumps moving blood through two separate circulatory systems in sequence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What do the two conjoined pumps of the heart do?

A
  1. one pump supplies blood to the lungs,
  2. the second pump delivers blood to the rest of the body.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do structures of the right side or right heart do?

A

Structures on the right side, or right heart, pump blood through the lungs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the two major divisions of the heart?

A
  1. Pulmonary circulation
  2. Systemic circulation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

System that pumps blood through lungs

A

This system is termed the pulmonary circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do structures of the left side or left heart do?

A

The left side, or left heart, sends blood throughout the systemic circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

System that pumps blood throughout all the body except the lungs

A

systemic circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Arteries

A

carry blood from the heart to all parts of the body,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What do arteries branch into

A

they branch into arterioles and even smaller vessels, ultimately becoming a fine meshwork of capillaries.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What allows the closest contact and exchange between the blood and the interstitial space?

A

Capillaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the order of what things blood flows through?

A

Arteries carry blood from heart to all parts of body

Arteries branch into arterioles and even smaller vessels, ultimately becoming capillaries

Venules and then veins carry blood from capillaries back to the heart.

So….

Arteries–> arterioles–>capillaries–> venules–> veins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the distribution of blood in the circulatory system?

A

9% is in the pulmonary circulation,

7% is in the heart, and

84% is in the systemic circulation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the three layers of the heart wall?

A
  1. epicardium
  2. myocardium
  3. endocardium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the three layers of the heart wall enclosed in?

A

Are enclosed in a double walled membranous sac- the Pericardium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The pericardium sac has three main functions:

A
  1. it prevents displacement of the heart during gravitational acceleration or deceleration,
  2. it serves as a physical barrier to protect the heart against infection and inflammation coming from the lungs and pleural space, and
  3. it contains pain receptors and mechanoreceptors that can cause reflex changes in blood pressure and heart rate.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Epicardium

A

The smoothness of outer layer of the heart

Minimizes friction between the heart wall and the pericardial sac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the thickest layer of the heart wall

A

the myocardium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The myocardium is composed of

A

The myocardium, is composed of cardiac muscle and is anchored to the heart’s fibrous skeleton.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Cardiomyocytes,

A

The heart muscle cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What do the cardiomyocytes do?

A

The heart muscle cells, cardiomyocytes, provide the contractile force needed for blood to flow through the heart and into the pulmonary and systemic circulations.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Endocardium

A

The internal lining of the myocardium,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is the endocardium composed of:

A

The endocardium, is composed of connective tissue and squamous cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How does the right heart receive venous blood?

A

The right heart receives venous blood from the systemic circulation through the superior and inferior venae cavae, which join and then enter the right atrium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What happens after the blood enters the right atrium?

A

Blood goes from RA to Right Ventricle.

Blood leaving the right ventricle enters the pulmonary circulation through the pulmonary artery, which divides into right and left branches to transport deoxygenated blood from the right heart to the lungs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What does the pulmonic artery divide into? What does the pulmonic artery do?

A

Divides into right and left branches to transport deoxygenated blood from the right heart to the lungs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What do the pulmonary arteries branch out into (after left and right branching)

A

The pulmonary arteries branch further into the pulmonary capillary beds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Where does carbon dioxide and oxygen exchange occur?

A

Pulmonary capillary beds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Pulmonary veins

A

Four pulmonary veins, two from the right lung and two from the left lung, carry oxygenated blood from the lungs to the left side of the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

How does oxygenated blood move through the heart?

A

Pulmonary veins–> left side of heart–> left atrium–> left ventricle–> aorta–> systemic arteries that supply the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What are the four chambers of the heart?

A

The heart has four chambers:

the left atrium
the right atrium
the right ventricle
the left ventricle.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What kind of pressure system is the right heart?

A

the right heart is a low-pressure system pumping blood through the lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What kind of pressure system is the left heart?

A

the left heart is a high-pressure system pumping blood to the rest of the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

The wall thickness of the heart is dependent on what?

A

The wall thickness of each cardiac chamber depends on the amount of pressure or resistance it must overcome to eject blood.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Atrioventricular (AV) valves where are they located?

A

They fall between the atria and ventricles.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What make up the four AV valves

A
  1. Tricuspid valve
  2. Mitral valve
  3. Aortic semilunar valve
  4. Pulmonary semilunar valve
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

How does blood leave the right ventricle?

A

Through the pulmonary semilunar valve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

How does blood leave the left ventricle?

A

Through the aortic semilunar valve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

What features of the heart ensures that blood flows only one way through the heart?

A
  1. Four heart valves,
  2. Four chambers &
  3. Pressure gradients they maintain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

The pumping action of the heart consists of what?

A

The pumping action of the heart consists of contraction and relaxation of the heart muscle, or myocardium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What counts as one cardiac cycle?

A

Each ventricular contraction and the relaxation that follows it constitute one cardiac cycle.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Diastole- what happens

A

During the period of relaxation, termed diastole, blood fills the ventricles.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Systole- what happens

A

The ventricular contraction that follows the blood filling the ventricles, termed systole, propels the blood out of the ventricles and into the pulmonary and systemic circulations.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

How many phases of the cardiac cycle are there?

A

Five phases of the cardiac cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Blood Flow during the Cardiac Cycle

A

????????

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Five phases of the cardiac cycles begin with what

A

The five phases of the cardiac cycle are said to begin with the opening of the mitral and tricuspid valves and atrial contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

What marks the end of one cardiac cycle?`

A

Closing of the mitral and tricuspid valves as passive ventricular filling begins marks the end of one cardiac cycle.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

What are the major coronary arteries?

A
  1. Right Coronary Artery (RCA)
  2. Left Coronary Artery (LCA)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

What do the RCA and LCA travel across?

What do they branch out to become?

A

traverse the epicardium, myocardium, and endocardium and branch to become arterioles and then capillaries.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

The left coronary artery divides into:

A
  1. left anterior descending artery (LAD)
  2. circumflex artery
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Left anterior descending artery (LAD)

A

supplies blood to portions of the left and right ventricles and much of the interventricular septum)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Circumflex artery

A

supplies blood to the left atrium and the lateral wall of the left ventricle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

What does the cardiac cycle require?

A

The cardiac cycle requires the transmission of the electrical impulses, called cardiac action potentials from the mycocardium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Conduction system

A

a collection of specialized cells that enable the myocardium to generate and transmit action potentials without input from the nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

What are cells that initiate signals called

A

Pacemakers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

Where are the pacemaker cells concentrated?

A

Two sites in the myocardium called nodes

  1. Sinoatrial node
  2. Atrioventricular node
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

What is the heart innervated by?

A
  1. The autonomic nervous system (both sympathetic and parasympathetic fibers)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

Conduction system steps: (SA–> AV)

A
  1. Electrical impulses arise in SA node
  2. In resting, SA node generates 60-100 action potentials per minute
  3. Each action potential travels rapidly from cell to cell and through the atrial myocardium, carrying the action potential onward to the AV node and causing both atria to contract–> systole begins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

Where do electrical impulses arise?

A

SA node

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

Where is the SA node located?

A

The SA node is located at the junction of the right atrium and superior vena cava, just superior to the tricuspid valve.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

In resting, how many action potentials does the SA node generate per minute?

A

60-100 per minute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

Where is the AV node located?

A

The AV node, located in the right atrial wall superior to the tricuspid valve and anterior to the ostium of the coronary sinus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

What does the AV node do?

A

it conducts the action potentials onward to the ventricles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

Depolarization

A

Electrical activation of the muscle cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

What is depolarization caused by?

A

Depolarization, is caused by the movement of ions, including sodium, potassium, calcium, and chloride, across cardiac cell membranes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

Repolarization

A

Deactivation of muscle cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

Membrane potential

A

Movement of ions into and out of the cell creates an electrical (voltage) difference across the cell membrane, called the membrane potential.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

What happens to the inside of the cell during depolarization?

A

The inside of the cell becomes less negatively charged as positive ions move inside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

What are the parts of a ECG?

A

P wave

PR interval

QRS complex

ST interval

QT interval

T wave

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

P wave of ECG

A

represents atrial depolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

PR interval

A

is a measure of time from the onset of atrial activation to the onset of ventricular activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

PR interval represents what?

A

The PR interval represents the time necessary for electrical activity to travel from the sinus node through the atrium, AV node, and His-Purkinje system to activate ventricular myocardial cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

The QRS complex represents what?

A

The QRS complex represents the sum of all ventricular muscle cell depolarization.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
74
Q

What occurs during the ST interval?

A

During the ST interval, the entire ventricular myocardium is depolarized.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
75
Q

T wave

A

represents ventricular repolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
76
Q

Automaticity

A

The property of generating spontaneous depolarization to threshold, enables the SA and AV nodes to generate cardiac action potentials without any external stimulus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
77
Q

Rhythmicity

A

Rhythmicity is the regular generation of an action potential by the heart’s conduction system.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
78
Q

What sets the rate for Rhythmicity?

A

SA node

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
79
Q

Cardiac innervation: What does the ANS influence

A
  1. rate of impulse generation (firing)
  2. depolarization of the myocardium
  3. repolarization of the myocardium
  4. strength of the atrial and ventricular contraction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
80
Q

What does sympathetic stimulation of nerve fibers do?

A

sympathetic stimulation increases electrical conductivity and the strength of myocardial contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
81
Q

What does parasympathetic stimulation of nerve fibers do?

A

vagal parasympathetic nerve activity does the opposite of sympathetic, slowing the conduction of action potentials through the heart and reducing the strength of contraction.

82
Q

What do the sympathetic and parasympathetic nerves do in the cardiac cycle?

A

The sympathetic and parasympathetic nerves affect the speed of the cardiac cycle (heart rate, or beats per minute)

83
Q

How does the parasympathetic nervous system affect the heart specifically?

A

The parasympathetic nervous system affects the heart through the vagus nerve, which releases acetylcholine.

Acetylcholine causes a decreased heart rate and slows conduction through the AV node.

84
Q

Acetylcholine

A

Acetylcholine causes a decreased heart rate and slows conduction through the AV node.

85
Q

Myocardial contractibility

A

Myocardial contractility is a change in developed tension at a given resting fiber length, which basically is the ability of the heart muscle to shorten.

Myocardial contractility is defined as the force with which the ventricles contract.

86
Q

Cardiac output- how is it calculated?

A

Cardiac output is calculated by multiplying the heart rate in beats per minute (beats/min) by the stroke volume (volume of blood ejected during systole) in liters per beat.

CO = HR x SV

87
Q

Stroke Volume

A

Volume of blood ejected during systole in liters per beat. (L/beat)

88
Q

Ejection fraction

A

With each heartbeat, the ventricles eject much of their blood volume, the amount ejected per beat is called the ejection fraction

89
Q

What increases ejection fraction?

A

The ejection fraction is increased by factors that increase contractility, such as increased sympathetic nervous system activity.

90
Q

How is the ejection fraction calculated?

A

The ejection fraction is calculated by dividing the stroke volume by the end-diastolic volume.

91
Q

What factors increase ejection fraction?

A

The ejection fraction is increased by factors that increase contractility, such as increased sympathetic nervous system activity.

92
Q

The factors that determine cardiac output?

A
  1. Preload
  2. Afterload
  3. Myocardial contractibility
  4. Heart rate
93
Q

What are the three factors that effect Stroke Volume?

A
  1. Preload
  2. Afterload
  3. Contractility
94
Q

Preload

A

Preload is the volume and pressure inside the ventricle at the end of diastole (ventricular end-diastolic volume [VEDV] and pressure [VEDP])

95
Q

Preload is determined by what?

A

Preload is determined by two primary factors:

(1) the amount of blood left in the ventricle after diastole (end-dystolic volume) and

(2) the amount of venous blood returning to the ventricle during diastole.

96
Q

During preload, What is end systolic volume dependent on?

A

End-systolic volume is dependent on the strength of ventricular contraction and the resistance to ventricular emptying.

97
Q

During preload, Venous return is dependent on

A

Venous return is dependent on blood volume and flow through the venous system and the atrioventricular valves

98
Q

Starling Law

A

Starling law of the heart indicates that the volume of blood in the heart at the end of diastole, as the volume determines the length of its muscle fibers, is directly related to the force of contraction during the next systole.

99
Q

Ventricular afterload

A

Ventricular afterload is the resistance to ejection of blood from the ventricle.

It is the load the muscle must move during contraction.

Afterload is formally defined as the load against which a muscle exerts its force (i.e., the load a muscle must overcome to contract).

100
Q

What is an index of afterload?

A

The aortic systolic pressure is an index of afterload.

101
Q

Before blood can be pumped out during systole, what must occur?

A

Pressure in the ventricle must exceed the aortic pressure before blood can be pumped out during systole.

102
Q

What does low aortic pressures (decreased afterload) enable the heart to do?

A

Low aortic pressures (decreased afterload) enable the heart to contract more rapidly and efficiently

103
Q

What does high aortic pressures (increased afterload) enable the heart to do?

A

high aortic pressures (increased afterload) slow contraction and cause higher workloads against which the heart must function to eject blood.

104
Q

Increased aortic pressure is the result of what?

A

Increased aortic pressure is usually the result of increased systemic vascular resistance (SVR),

105
Q

What is systemic vascular resistance (SVR) also known as?

A

Total Peripheral Resistance (TPR)

106
Q

How to calculate SVR?

A

SVR is calculated by dividing the mean arterial pressure by the cardiac output

107
Q

Myocardial Contractility

A

Force of contraction

or

Degree of myocardial fiber shortening

108
Q

Three major factors determine the force of contraction:

A
  1. Changes in the stretching of the ventricular myocardium caused by changes in VEDV (preload).
  2. Alterations in the inotropic stimuli of the ventricles
  3. Adequacy of myocardial oxygen supply.
109
Q

Inotropic agents

A

Hormones, neurotransmitters, or medications that affect contractility are called inotropic agents.

110
Q

What are the most important inotropic agents?

A

The most important endogenous positive inotropic agents are epinephrine and norepinephrine released from the sympathetic nervous system.

111
Q

What is the most important negative inotropic agent?

A

The most important negative inotropic agent is acetylcholine released from the vagus nerve.

112
Q

How does severe hypoxemia effect contractility?

A

With severe hypoxemia (arterial O2 saturation less than 50%), contractility is decreased.

113
Q

How does moderate hypoxemia effect contractility?

A

Moderate degrees of hypoxemia may increase contractility by enhancing the myocardial response to circulating catecholamines.

114
Q

Changes in preload, afterload and contractility can lead to what?

A

Heart failure

115
Q

What is the primary determinant of heart rate?

A

SA node

116
Q

The control of heart rate includes activity of:

A
  1. The central nervous system,
  2. Autonomic nervous system,
  3. Neural reflexes,
  4. Atrial receptors, and
  5. hormones
117
Q

What is involved in neural reflex?

A

Baroreceptor reflexes

118
Q

What does output from baroreceptor reflex influence?

A

Output from the baroreceptor reflexes influences short-term regulation of the vascular smooth muscle of resistance arteries, myocardial contractility, and heart rate, all components of blood pressure control.

119
Q

What does baroreceptors do if bp decreases

A

If blood pressure decreases, the baroreceptor reflex accelerates the heart rate, increases myocardial contractility, and increases vascular smooth muscle contraction in the arterioles, thus raising blood pressure.

120
Q

What is baroreceptor reflex important for maintaining?

A

This reflex is critical to maintaining adequate tissue perfusion.

121
Q

What do baroreceptor reflexes do when bp increases?

A

When the blood pressure increases, the baroreceptors increase their rate of discharge,

These reflexes increase parasympathetic activity and decrease sympathetic activity, causing the resistance arteries to dilate, decreasing myocardial contractility and the heart rate.

122
Q

Bainbridge reflex

A

The Bainbridge reflex is the name for the changes in the heart rate that may occur after intravenous infusions of blood or other fluid.

123
Q

Peripheral vascular system

A

Peripheral vascular system is the term used to describe the part of the systemic circulation that supplies the skin and the extremities, particularly the legs and feet.

124
Q

Blood vessels are composed of three layers:

A
  1. The tunica intima (innermost layer)
  2. The tunica media (middle layer)
  3. The tunica externa or adventitia (outermost layer)
125
Q

Blood flow

A

Blood flow, the amount of fluid moved per unit of time

126
Q

How is blood flow expressed?

A

Is usually expressed as liters or milliliters per minute (L/min or ml/min).

127
Q

Factors that influence blood flow include?

A

Pressure,

Resistance,

Velocity,

Laminar versus turbulent flow, and

Compliance,

128
Q

Of the factors that affect blood flow, what is the most important?

A
  1. Pressure
  2. Resistance
129
Q

Factors affecting blood flow: Pressure

A

Pressure in a liquid system is the force exerted on the liquid per unit area

130
Q

How is pressure expressed in units?

A

millimeters of mercury (mm Hg),

or torr (1 torr = 1 mm Hg).

131
Q

Factors affecting blood flow: Resistance

A

Resistance is the opposition to blood flow.

132
Q

What contributes to resistance?

A

Most opposition to blood flow results from the diameter and length of the vessels.

133
Q

Why does changes in blood flow through an organ occur?

A

Changes in blood flow through an organ result from changes in the vascular resistance within the organ because of:

  1. increases or decreases in vessel diameter and
  2. the opening or closing of vascular channels.
134
Q

How is resistance related to blood flow?

A

Resistance in a vessel is inversely related to blood flow—that is, increased resistance leads to decreased blood flow.

135
Q

What is the most important factor determining resistance in a single vessel?

A

Clinically, the most important factor determining resistance in a single vessel is the radius or diameter of the vessel’s lumen.

136
Q

Viscosity

A

The consistency of fluid

137
Q

Viscosity: Thick fluid moves more slowly, how does that affect resistance?

A

Thick fluids move more slowly and cause greater resistance to flow than thin fluids

138
Q

What does the viscosity of blood depends on what?

A

The viscosity of blood depends on the red cell content.

Greater the percentage of rbc, the more viscous the blood.

139
Q

Blood velocity

A

Blood velocity, or speed, is the distance blood travels in a unit of time,

140
Q

How is blood velocity expressed?

A

usually centimeters per second (cm/sec).

141
Q

How is Blood velocity related to blood flow?

A

It is directly related to blood flow (the amount of blood moved per unit of time)

142
Q

How is Blood velocity related to cross-sectional area of the vessel?

A

inversely related to the cross-sectional area of the vessel in which the blood is flowing

143
Q

Laminar flow

A

In laminar flow, concentric layers of molecules move “straight ahead,” with each layer flowing at a slightly different velocity

144
Q

What is turbulent blood flow caused by?

A

Where flow is obstructed, the vessel turns of branches, or blood flows over rough surfaces, the flow becomes turbulent with whorls or eddy current that produce noise, causing murmur to be heard.

145
Q

Relationship between turbulence and resistance?

A

Resistance increases with turbulence

146
Q

Vascular Compliance

A

Vascular compliance is the increase in volume a vessel can accommodate with a given increase in pressure.

147
Q

What is the opposite of compliance?

A

Stiffness is the opposite of compliance.

148
Q

What is arterial blood pressure determined by:

A

The arterial blood pressure is determined by the cardiac output multiplied by the peripheral resistance

CO x PR = BP

149
Q

Systolic Blood Pressure

A

The systolic blood pressure is the highest arterial blood pressure after ventricular contraction or systole.

150
Q

Diastolic Blood Pressure

A

The diastolic blood pressure is the lowest arterial blood pressure that occurs during ventricular filling or diastole.

151
Q

Mean Arterial Pressure (MAP)

A

The average pressure in the arteries throughout the cardiac cycle

152
Q

What does the MAP depend on?

A

depends on:

  1. The elastic properties of the arterial walls and
  2. The mean volume of blood in the arterial system.
153
Q

Tissue Perfusion

A

Blood supply to the capillary beds

154
Q

The cardiac output can be changed by:

A

The cardiac output (minute volume) of the heart can be changed by:

  1. Alterations in the heart rate,
  2. stroke volume (volume of blood ejected during each ventricular contraction),
  3. or both.
155
Q

What is primarily a function of arteriolar diameter?

A

Total resistance in the systemic circulation (known as SVR or TPR)

156
Q

How does Baroreceptors affect Cardiac output?

A

When activated (stretched), the baroreceptors decrease cardiac output by lowering the heart rate, stroke volume, and peripheral resistance, and thus lower blood pressure.

157
Q

What are arterial chemoreceptors?

A

Specialized areas within the aortic arch and carotid arteries are sensitive to concentrations of O2, carbon dioxide (CO2), and hydrogen ions (pH) in the blood

158
Q

Arterial chemoreceptors?

A

A decrease in arterial oxygen concentration (hypoxemia), an increase in arterial PaCO2 concentration, or to a lesser extent a decrease in arterial blood pH causes a reflexive increase in heart rate, stroke volume, and blood pressure.

159
Q

Effect of hormones on bp? By constricting or dilating the arterioles in organs, hormones can:

A

By constricting or dilating the arterioles in organs, hormones can

(1) increase or decrease the flow in response to the body’s needs,

(2) redistribute blood volume during hemorrhage or shock, and

(3) regulate heat loss.

160
Q

What are the key vasoconstrictor hormones include:

A

angiotensin II, vasopressin (or antidiuretic hormone), epinephrine, and norepinephrine.

161
Q

The main vasodilator hormones are:

A

The main vasodilator hormones are the atrial natriuretic hormones.

162
Q

How do aldosterone, vasopressin and natriuretic hormones influence stroke volume and bp?

A

By causing fluid retention or loss, aldosterone, vasopressin, and the natriuretic hormones can influence stroke volume and thus blood pressure.

163
Q

What are the vasoconstrictor hormones that are part of the renin-angiotensin-aldosterone system:

A

The vasoconstrictor hormones include epinephrine; norepinephrine; angiotensin II, which is part of the renin-angiotensin-aldosterone system;

164
Q

How do vasopressin and aldosterone affect bp?

A

Vasopressin and aldosterone, however, affect blood pressure by increasing blood volume through their influence on fluid reabsorption in the kidney and by stimulating thirst.

Vasopressin causes the reabsorption of water from tubular fluid in the distal tubule and collecting duct of the nephron. Aldosterone, the end product of the renin-angiotensin-aldosterone system, stimulates the reabsorption of sodium, chloride, and water from the same locations in the kidney

165
Q

Effect of natriuretic peptides (NPs) or hormones

A

Increased pressure or diastolic volume in the heart stimulates the release of these peptide hormones.

166
Q

Three principal natriuretic peptides:

A
  1. Atrial Natriuretic Peptide (ANP)
  2. B-type Natriuretic Peptide (BNP)
  3. C-type natriuretic peptide (CNP),
  4. and urodilatin,
167
Q

Other mediators that have been demonstrated to cause arteriolar vasodilation or vasocontriction?

A

Some of the vasodilating mediators include nitric oxide (NO), adrenomedullin (ADM), the endothelins, and prostacyclin.

168
Q

Hypertension

A

Hypertension is consistent elevation of systemic arterial blood pressure.

169
Q

How has hypertension been defined in numbers:

A

It has recently been redefined as a sustained systolic blood pressure (SBP) of 130 mm Hg or a diastolic blood pressure (DBP) of 80 mm 593Hg or greater

170
Q

Most cases of hypertension are diagnosed as what?

A

Primary hypertension

171
Q

What is primary hypertension also called?

A

(also called essential or idiopathic hypertension)

172
Q

Secondary Hypertension:

A

Secondary hypertension is caused by an underlying disorder such as renal disease.

Secondary hypertension is caused by an underlying disease process or medication that raises PVR or cardiac output.

173
Q

Cause of Primary hypotension:

A

A combination of genetic and environmental factors

174
Q

Risk factors for Primary Hypertension:

A

Family History

Diet

Tobacco and Alcohol Consumption

Obesity and glucose intolerance

175
Q

Complicated Hypertension

A

As hypertension becomes more severe and chronic, tissue damage can occur in the blood vessels and tissues leading to target organ damage in the heart, kidney, brain, and eyes.

176
Q

Myocardial Hypertrophy

A

Hypertrophy is characterized by a myocardium that is thickened, scarred, and less able to relax during diastole, leading to heart failure with preserved ejection fraction.

177
Q

Hypertensive crisis

A

Hypertensive crisis is rapidly progressive hypertension in which systolic pressure is ≥180 mmHg and or diastolic pressure is ≥120 mmHg.

178
Q

Angiotensin family:

A

which consists of angiotensin I, angiotensin II, and angiotensin III.

179
Q

Angiotensin I

A

Angiotensin I is the precursor of angiotensin II

180
Q

Actions of Angiotensin II and What do the actions cause?

A

The most prominent actions of angiotensin II are :

  1. vasoconstriction and
  2. stimulation of aldosterone release.

Both actions raise bp

181
Q

How does Angiotensin II cause vasoconstriction directly?

A
  1. The compound acts directly on vascular smooth muscle (VSM) to cause contraction.
182
Q

How does Angiotensin II cause vasoconstriction indirectly?

A

angiotensin II can cause vasoconstriction indirectly by acting on:

(1) sympathetic neurons to promote norepinephrine release,

(2) the adrenal medulla to promote epinephrine release, and

(3) the central nervous system to increase sympathetic outflow to blood vessels.

183
Q

Where is aldosterone made?

A

Angiotensin II acts on the adrenal cortex which produces Aldosterone.

184
Q

How are aldosterone secretions enhanced?

A

Aldosterone secretion is enhanced when sodium levels are low and when potassium levels are high.

185
Q

How does aldosterone effect blood volume and blood pressure?

A

After being released from the adrenal cortex, aldosterone acts on distal tubules of the kidney to cause retention of sodium and excretion of potassium and hydrogen.

-Because retention of sodium also causes water to be retained, aldosterone increases blood volume, which causes blood pressure to rise.

186
Q

Renin

A

Renin catalyzes the formation of angiotensin I from angiotensinogen.

187
Q

Release of renin can be triggered by multiple. factors

A

Release increases in response to a decline in blood pressure, blood volume, plasma sodium content, or renal perfusion pressure.

188
Q

What inhibits the release of renin secretion?

A

Renin secretion is inhibited by elevation of blood pressure, blood volume, and plasma sodium content.

189
Q

Angiotensin-Converting Enzyme (Kinase II):

A

ACE catalyzes the conversion of angiotensin I (inactive) into angiotensin II (highly active).

190
Q

How fast does conversion of angiotensin I –> angiotensin II occur? Why?

A

Because ACE is abundant, conversion of angiotensin I into angiotensin II occurs almost instantaneously after angiotensin I has been formed.

191
Q

The RAAS, acting through angiotensin II, raises blood pressure through two basic processes:

A

The RAAS, acting through angiotensin II, raises blood pressure through two basic processes: vasoconstriction and renal retention of water and sodium.

192
Q

?????

A

Vasoconstriction raises blood pressure by increasing total peripheral resistance; retention of water and sodium raises blood pressure by increasing blood volume.

193
Q

ACE inhibitors are important for what?

A

The ACE inhibitors are important drugs for treating hypertension, heart failure, diabetic nephropathy, and MI.

194
Q

Adverse Effects of ACE inhibitors

A

Their most prominent adverse effects are cough, angioedema, first-dose hypotension, and hyperkalemia.

195
Q

ACE inhibitors produce their beneficial effects and adverse effects by:

A

(1) reducing levels of angiotensin II (through inhibition of ACE) and

(2) increasing levels of bradykinin (through inhibition of kinase II)

196
Q

Through reducing reducing levels of Angiotensin II, what do ACE inhibitors do?

A

By reducing levels of angiotensin II, ACE inhibitors can dilate blood vessels (primarily arterioles and, to a lesser extent, veins); reduce blood volume (through effects on the kidney); and, importantly, prevent or reverse pathologic changes in the heart and blood vessels mediated by angiotensin II and aldosterone.

197
Q

What suffix does all ACE inhibitors end in?

A

“prils”

198
Q

If a patient reports angiodema, what should the patient never take again?

A

ACE inhibitors

199
Q

Drug interactions caused by ACE inhibitors:

A
  1. Diuretics
  2. Antihypertensive Agents
  3. Drugs that raise potassium levels
  4. Lithium
  5. NSAIDs
200
Q
A

PATHO/PHARM I (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions