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Repair And Regeneration > Week 5 Part 2 > Flashcards

Week 5 Part 2 Flashcards

1
Q

What can lead to central sensitisation at an activation of CNS?

A

Low level c-fibre activity

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2
Q

What are acting in the DRG?

A

Sympathetic neurons

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3
Q

What is recorded in Lamina 5?

A

Multimodal cells

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4
Q

What are changes in the nervous system?

A

Receptive field expansion due to central sensitisation

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5
Q

What are responses of uninjured fibres?

A

Mediate Allodynia and hyperalgesia

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6
Q

What becomes spontaneously active?

A

C fibres

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7
Q

What sprouts peripherally?

A

C fibres

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8
Q

What are phenotypic switching due to?

A

Trophic factors

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9
Q

What are the roles of C-fibres?

A

Neurotransmitter down-regulation
Loss of glomerular complexes in Lamina II
Reduced ability to activate spinal cord neurons

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10
Q

What are the roles of A-fibres?

A

Phenotypic switching of neurotransmitters
Substance P and CGRP are produced
Increased ability to activate spinal cord neurons

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11
Q

What does A-fibre marker studies suggest?

A

AB fibres sprout into Lamina II

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12
Q

How many afferents are found in the injured state?

A

23 hair follicles

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13
Q

How many afferents in the control state?

A

13 hair follicles

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14
Q

What is A-fibre markers inadequate?

A

Phenotypic switching in the cells transporting CTB-HRP

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15
Q

What happens after injury?

A

CTB labels the unmyelinated fibres too

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16
Q

What is AB fibre genetically labelled with?

A

PV promoter-driven tomato red fluorescence protein

17
Q

What is not labelled in Lamina II despite allodynia?

A

No sprouting

18
Q

What does A fibre bulk labelling method show?

A

Phenotypic switch

19
Q

What does single fibre fills show?

A

Wide morphological variation

20
Q

What does C fibre binding studies show?

A

Extracellular spread

21
Q

What is central sensitisation?

A

Long-term potentiation in the spinal cord

22
Q

What does C fibres acting on second order neurons in spinal cord release?

A

Glutamate/ substance P/ neurotrophic factors

23
Q

What is monosynaptic strengthening?

A

Opening up Ca2+ channels in the second order neurons and allowing this cell to respond more effectively to C-fibre input
Strengthening of that cell to consequence stimuli

24
Q

What is found in second-order cell?

A

Heterosynaptic strengthening

25
Q

How can Ab-fibres maintain the increased activity in second order nerve?

A

Releasing substance p

acting on NK1 receptors

Repair And Regeneration (16 decks)

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