Week 5 Paediatrics + SIDS Flashcards

1
Q

Anatomy

Paeds often have a large and heavy head in proportion to their body, At what age does the Fontanelles fuse together (skull gaps)?

A. 6 months
B. 12 months
C. 18 months
D. 24 months

A

D. 24 months

  • Relatively large and heavy in proportion to the body
  • Up to 19% surface area compared with 9% for adults = ↑ heat loss
  • Fontanelles present (completely close usually by 2 years old

Source - Lecture Slides

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2
Q

Why do paediatrics lose a lot of body heat through their head?

A
  • Up to 19% surface area compared with 9% for adults = ↑ heat loss
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3
Q

Paediatrics have weaker ligaments and muscles in the neck. At what site do we generally see injury?

A. C1 - C2
B. C5 - C6
C. SCIWORA
D. Both A and C

A

D. Both A and C

Weak ligaments and muscles
C1-C2 injuries more common
SCIWORA

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4
Q

According to the lecture slide 17 Peads Part 1,

What is a sign of child abuse when it comes fractured ribs?

A

3+ # ribs are considers child abuse. This is due to blunt trauma rarely causes #ribs in paediatrics.

Therefore, # ribs = severe injury

It also good to not that anatomically

  • Paediatric ribs are horizontal in design
  • Intercostal muscles are less developed = diaphragmatic breathers (belly breathers)
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5
Q

What is Sudden Infant Death Syndrome (SIDS)?

A

Sudden infant death syndrome (SIDS) is the unexplained death, usually during sleep, of a seemingly healthy baby less than a year old. SIDS is sometimes known as crib death because the infants often die in their cribs.

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6
Q

What is Obstructive Sleep Apnoea (OSA)?

A

OSA is a condition causing repetitive episodes of upper airway obstruction during sleep, leading to hypoxia and/or sleep disturbance.

It is important to note that muscle use for breathing still continues during the airway obstruction.

This is different to central sleep apnoea where the brain during an episode does not send signals to breath

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7
Q

What is the main cause for Obstructive Sleep Apnoea (OSA) in children?

A. Enlarged tonsils and adenoids
B. Obesity
C. Foreign Body
D. All of the above

A

A. Enlarged tonsils and adenoids

Obesity does increase the risk of OSA but is more common in adults

A foreign body is not a cause of OSA

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8
Q

Risk factors for Obstructive Sleep Apnoea (OSA)

Hint: F MOBCAP

A
F - Family Hx of OSA
M - Male Gender
O - Obesity
B - Bronchopulmonary Dysplasia
C - Craniofacial Anomalies
A - Antenatal Smoking
P - Premature Birth

Bronchopulmonary Dysplasia = Damage caused by mechanical ventilation and excessive oxygen use

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9
Q

What is not a sign and symptom of Obstructive Sleep Apnoea (OSA)

A. Loud Snoring
B. Chokes, Gasps, Snorts in sleep
C. Breathing through nasal passage only 
D. Profuse sweating during sleep
E. Dysphagia
A

C. Breathing through nasal passage only

Babies prefer to nose breath and breathing through their mouth instead of their nose at night is a SxSx of OSA

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10
Q

Why are people with Down Syndrome likely to suffer from sleep disorders?

A
  • Hypotonia
  • Hypertrophy of adenoid and tonsils
  • Poor coordination of airway movements
  • Obesity
  • Central apnoea
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11
Q

True or False

Prader Will Syndrome is associated with hypertonia and tall stature?

A

False

Prader Willi Syndrome. This is a rare (estimated prevalence for the Australian population 1in25 000) and complex genetic syndrome associated with developmental delay, hypotonia, short stature and failure to thrive in infancy

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12
Q

Which overgrowth syndrome is related to Obstructive Sleep Apnoea and an increase in the likelihood of cancer?

A. Disruptive Mood Dysregulation Disorder
B. Prader Willi Syndrome
C. Beckwith-Tiedmann Syndrome
D. Down Syndrome

A

C. Beckwith-Tiedmann Syndrome

This is an overgrowth syndrome.

  • macrosomia and rapid growth during childhood,
    • sometimes with asymmetry; omphalocele and macroglossia.

An increased risk of cancers,

  • Wilm’s tumours,
  • Hepatoblastoma
  • Rhabdomyosarcomas.

Sleep-disordered breathing is common, it can in part be explained by upper airway narrowing but central apnoeas may also occur.

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13
Q

What is the difference between Obstructive Sleep Apnoea (OSA) and Central Sleep Apnoea (CSA)?

A

OSA - is airflow is diminished or absent in the presence of persistent chest and abdominal movements due to partial or complete blockage of upper airway

CSA - breathing stops and there is a pause before there is an effort to breathe again

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14
Q

What are the 4 genetic syndromes associated with Sleep Disorders of Infancy?

A

Down Syndrome
Prader Willi Syndrome
Hyperphagia
Beckwith-Tiedmann Syndrome (BWS)

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15
Q

How is Gastroesophageal Reflux Disease (GORD) associated with Sleep Apnoea?

A

Reflux may trigger apnoea via the laryngeal chemoreflex or GORD may induce laryngeal swelling.

Apnoea has been shown to improve after successful treatment of GORD in infants.

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16
Q

Which is not a risk factor for SIDS?

A. Prone or Side Sleeping
B. Sleeping w/ fluffy toys and bedding
C. Sharing the same bed with a parent
D. Sleeping in the same room with parents
E. Aboriginal Ethnicity
F. Being a sibling of a SIDS victim

HINT: BABIES

A

D. Sleeping in the same room with parents

Keep the baby close by.

Keeping the baby in the same room as the mother, but in a different bed, lessens the risk of SIDS.

17
Q

Which is not a protective factor for SIDS?

A. Immunisations
B. Breastfeeding
C. Bed sharing with parent
D. Using a Pacifier

A

C. Bed sharing with parent

Babies should sleep in a crib or bassinet and not the parents’ bed. Babies can suffocate in an adult bed. They can slip below the headboard or become entangled in the covers. In addition, a sleeping parent can accidentally roll over and suffocate them without waking.

18
Q

What does the acronym BABIES stand for in regards to SIDS?

A

B - Babies should be placed to sleep on their backs
A - Avoid Fluffy bedding and toys
B - Babies should share the room but not parents bed
I - Indigenous Ethnicity
E - Eliminate environmental stressors (smoking)
S - Sibling of SIDS victim

19
Q

Question regarding the pathogenesis of SIDS

  • What is the Triple Risk model for SIDS?

Hint: UVE

A

Triple Risk = An infant with an

(U)nderlying vulnerability - genetic pattern, brainstem abnormality) - who (E)xperiences a trigger - OSA, maternal smoking, infection at a (V)ulnerable stage of the CNS or immune system

20
Q

Abnormalities in _________ signalling and _______ deficiency in the medullary areas which participate in autonomic ventilatory and BP response to hypoxia have been found in SIDS infants.

A. Serotonin, Serotonin
B. GABA, Noradrenaline
C. Noradrenaline, GABA
E. Acetylcholine, Acetylcholine

A

A. Serotonin

Abnormalities in Serotonin signalling and Serotonin deficiency in the medullary areas which participate in autonomic ventilatory and BP response to hypoxia have been found in SIDS infants.

Furthermore, serotonin signalling is altered by exposure to nicotine, hence why smoking increase risk of SIDS

21
Q

Immunisation:

A. Been shown to increases the risk of SIDS
B. decrease the risk of SIDS
C. It neither increases nor decreases
D. It only decreases if the child is aged 1+ year old

A

There is strong evidence from a meta-analysis that immunisation is associated with a decreased risk of SIDS.

Parents should be advised to immunise their babies according to the national immunisation schedule.

22
Q

What is Apnoea of Infancy?

A. Obstructive Sleep Apnoea due to a foreign body

B. Caused by pharyngeal instability/collapse, neck flexion or nasal obstruction. Absence of airflow in the presence of inspiratory efforts (muscle contractions).

C. Caused by decreased central nervous system stimuli to respiratory muscles. Both the respiratory effort and airflow cease simultaneously (absence of chest wall movement and airflow).

D. An unexplained episode of cessation of breathing for 20 seconds or longer, or a shorter respiratory pause associated with bradycardia, cyanosis, pallor, and/or marked hypotonia.

A

D. Apnoea of infancy is an unexplained episode of cessation of breathing for 20 seconds or longer, or a shorter respiratory pause associated with bradycardia, cyanosis, pallor, +/- marked hypotonia.

Central apnoea is the decrease of CNS stimuli to respiratory muscles. Both the respiratory effort and airflow cease simultaneously (absence of chest wall movement and airflow).

Obstructive apnoea is caused by pharyngeal instability/collapse, neck flexion or nasal obstruction. Absence of airflow in the presence of inspiratory efforts (There is the presence of chest wall movement but no airflow).

Mixed apnoea has a mixed aetiology. Central apnoea is either preceded (usually) or followed by an obstructed respiratory effort

Source: RCH website
https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/apnoea_neonatal/

23
Q

What is the definition of Apparent Life-Threatening Events (ALTE)

A. Characterized by some combination of apnoea (central or occasionally obstructive), colour change (usually cyanotic or pallid but occasionally erythematous or plethoric), marked changes in muscle tone (usually marked limpness), choking, or gagging

B. Idiopathic apnoea in response to underlying illness or pain

C. Three or more periods with no respiratory effort lasting 3 seconds or more in a 20 second period and does not involve changes in heart rate or colour

D. Caused by decreased central nervous system stimuli to respiratory muscles. Both the respiratory effort and airflow cease simultaneously (absence of chest wall movement and airflow).

A

A. “An apparent life-threatening event (ALTE) is defined as an episode that is frightening to the observer and is characterized by some combination of apnoea (central or obstructive), colour change (cyanotic, pallid, erythematous or plethoric) change in muscle tone (usually diminished), and choking or gagging”.

The source is the same as Jacqui’s definition from pre-readings:

https://emedicine.medscape.com/article/1418765-overview

24
Q

Why do Paediatrics have more ‘protuberant’ abdomens even though they have smaller stomach capacity?

A
  • Intercostal muscles still developing –> diaphragmatic breathers
  • Organs are larger in relation to body size (especially the liver)
  • Stand with a different posture to compensate for spine curvature and developing muscles

On a side note, paediatrics are more prone to infection, obstruction, constipation and malabsorption in the GI tract compared to adults.

25
Q

What is the Eustachian tube?

What is its role?

Why it is more likely to be an area of infection in paediatrics?

A

The Eustachian Tube is a canal connecting the middle ear to the nasopharynx equalizing the pressure within the middle ear and the air outside the body.

Infection in Peads occurs due to
- Smaller Eustachian tubes (wide and straight) and are more level in children –> difficult for fluid to drain out.

  • A child’s immune system isn’t as effective as an adult’s because it’s still developing.
  • As part of the immune system, the adenoids respond to bacteria passing through the nose and mouth. Sometimes bacteria get trapped in the adenoids, causing a chronic infection that can then pass on to the eustachian tubes and the middle ear.
    https: //www.nidcd.nih.gov/health/ear-infections-children
26
Q

What are the differences in Cardiovascular Compensation for shock between adults and Paediatrics?

A

Adults HR x SV = CO

Neonates depend on HR to Increase CO since they cannot increase SV due to underdeveloped Left Ventricle. Therefore, any increase in BP is strongly dependent on PVR and HR.

27
Q

True or False

Paediatrics have excellent sympathetic innervation but poor parasympathetic innervation?

A

False

Paediatrics Poor Sympathetic innervation but good parasympathetic innervation –> Poor tachycardia response

28
Q

Which digestive enzyme do paediatrics lack for the first 2 - 4 months of life?

A. Pancreatic Amylase (Carbohydrate Digestion)
B. Pepsin (Protein Digestion)
C. Peptidase (Protein Digestion)
D. None of the above

A

A. Pancreatic Amylase (Carbohydrate Digestion)

Stomach pH is 5 compared to adults at pH 2

  • Overall decreased pancreatic enzyme activity
  • Intolerance to starches
  • Decrease lactase levels –> incomplete absorption of lactose
  • Decreased Lipase - responsible for digesting and absorbing fats.