Week 5: Inflammatory mediators biological effects

Question 1

Histamine

Answer 1

redness, heat, swelling, airway constriction

Question 2

Does histamine act as a chemoattractant?

Answer 2

No

Question 3

PGE2

Answer 3

vasodilate, increase permeability, cause pain

Question 4

PGD2

Answer 4

bronchoconstriction

Question 5

TXA2

Answer 5

platelet aggregation (vasoconstriction)

Question 6

PGI2

Answer 6

opposes platelet aggregation (vasodilation), pain

Question 7

LTB4

Answer 7

chemotaxis of white cells and reduces pain

Question 8

LTC4, LTD4, LTE4

Answer 8

airway constriction, eosinophil chemotaxis, vascular permeability, DC maturation, mucous production

Question 9

Kinins

Answer 9

Potent vasodilator, edema formation, pain

Question 10

Redness/vasodilation

Answer 10

Histamine, PGE2, PGI2, kinins

Question 11

Swelling/increased vascular permeability

Answer 11

Histamine, LTC4, LTD4, LTE4, Kinins

Question 12

Pain/reduces threshold

Answer 12

PGE, PGI, LTB4, Kinins

Question 13

Chemotactic factor

Answer 13

LTB4 (neutrophils), LTC4, LTD4, LTE4

Question 14

Fever

Answer 14

PGEs

Question 15

Bronchoconstriction

Answer 15

Histamine, Peptido-leukotrienes, kinins, PGD2

Question 16

Hypotension

Answer 16

Kinins, histamine