Week 5: Autoimmune diseases and their autoantibodies

Question 1

Systemic lupus erythematosous

Answer 1

SOAP BRAIN MD, mostly a relapsing fever with joint issues and a malar rash. Anti-dsDNA and anti-Smith protein

Question 2

Rheumatoid Arthritis

Answer 2

Affects PIP joints, wrist and elbows, large masses on those areas. Anti-cyclic citrullinated peptides

Question 3

Sjogren

Answer 3

Dry eyes and mouth. Anti-ribonucleoproteins SS-A and SS-B antibodies

Question 4

Systemic sclerosis (scleroderma)

Answer 4

Sclerodactyly starting at distal fingers, Reynaud’s, Interstitial fibrosis. CREST syndrome (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia). Anti-Scl-70

Question 5

Dermatomyositis

Answer 5

Muscle weakness and skin rash. anti-Mi2, anti-Jo1, anti-P155/P140

Question 6

Polymyositis

Answer 6

Muscle and systemic involvement is similar to that seen in dermatomyositis, except for the lack of skin involvement. anti-Jo1, which is directed against histidyl t-RNA synthetase.

Question 7

Mixed connective tissue disease

Answer 7

Contains a mixture of the last 6 autoimmune diseases. Will also contain anti-U1-RNP