Week 5/6 Flashcards
Micromeritics is defined as the science of
small particles
Particle size can affect\_\_\_\_\_\_\_\_. [Select all that apply] appearance texture dissolution rate bioavailability diffusion partition
appearance
texture
dissolution rate
bioavailability
By decreasing the particle size, what type of stability can be enhanced in a suspension dosage form?
physical stability
chemical stability
microbiological stability
physical stability
Particle shape can affect\_\_\_\_\_\_\_\_. [Select all that apply] flow packing texture bioavailability diffusion dissolution
flow
packing
texture
A powder with an angle of repose below 35oC can be characterized as?
freely flowing
Which physical property of the particle will most affect the rate of drug absorption?
particle size
particle shape
particle angle of repose particle porosity
particle density
particle size
A powder dosage form is defined as a/an? drug powder or API drug powder mixed with excipients powder for reconstitution agglomeration of powders
drug powder mixed with excipients
A granule dosage form is defined as? drug powder or API drug powder mixed with excipients powder for reconstitution agglomeration of powders
agglomeration of powders
Powders for reconstitution are made to? increase in the shelf-life of the drug increase the portability of the drug decrease the weight of the drug product reduce the doses needed of the drug
increase in the shelf-life of the drug
T/F Dusting powders are used for systemic application
false
T/F Dusting powders must be light and fluffy to ensure their efficacy.
false
Drugs that typically undergo _______ are prepared by dry granulation
hydrolysis reactions
Hygroscopic drugs absorb ______ when they come into contact with water and therefore should be ______ in powder & granule dosage forms
moisture; avoided
Forming different crystal forms of the drug is a sign of _______ instability in powder & granule dosage forms.
physical
T/F Powder & granule dosage forms are an excellent option in extending the shelf-life of chemically unstable drugs.
true
Dry powder inhalers are powder dosage forms intended for the ______ route of administration
pulmonary
Drug X has a MW of 330 Da and a log Ko/w of 1.4. It is available as a powder for a solution that the pharmacist reconstitutes before dispensing and granules for suspension. What is the rate-limiting step for Drug X in the POWDER for the SOLUTION? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant
Partition coefficient
Drug X has a MW of 330 Da and a log Ko/w of 1.4. It is available as a powder for a solution that the pharmacist reconstitutes before dispensing and granules for suspension. What is the rate-limiting step for Drug X in the GRANULE for SUSPENSION? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant
Dissolution rate
A tablet is defined as a solid dosage form [select all that apply]
- with drug and excipients prepared by compression
- with drug and excipients prepared by molding
- with drug and excipients prepared by homegenization
- with drug and excipients prepared by blending
with drug and excipients prepared by compression
with drug and excipients prepared by molding
Match the process with its definition: Disintegration Deaggregation Dissolution Diffusion options: -coarse particles break up into fine particles -desegregation of constituent particles -solute molecules move down the concentration gradient -a solute entering a solution
Disintegration: desegregation of constituent particles
Deaggregation: coarse particles break up into fine particles
Dissolution: a solute entering a solution
Diffusion: solute molecules move down the concentration gradient
Rank the different types of tablets in terms of their dissolution rate from fastest to slowest: MR, RDT, and IR
RDT>IR>MR
Which of the following types of tablets are the cheapest to manufacture?
RDT
IR
MR
IR
Which of the following tablets would be best suited for chronic use?
RDT
IR
MR
MR
T/F All tablets undergo compression.
false
Which type of tablet is suitable for incompatible drugs? Sugar-coated Effervescent Compressed Multi-compressed
Multi-compressed
How can tablets be classified based on their release rate?
RDT, IR, MR
Sugar-coated, gelatin-coated, film-coated
Buccal, sublingual, vaginal
Compressed, chewable, effervescent
RDT, IR, MR
Which type of coating may be used to modify the drug dissolution rate? [Select all that apply]
Gelatin coating
Film coating
Sugarcoating
Film coating
Which type of tablet undergoes mechanical disintegration before absorption? Chewable Effervescent Vaginal Buccal
Chewable
Which type of tablet(s) undergo(es) slow dissolution? [Select all that apply: Buccal Sublingual Vaginal Effervescent
Buccal and vaginal
What drug property is needed for incorporating the drug in tablet dosage form?
Compressible
Potent
Protein-based
Compressible
Drug T has two formulations – A & B. Based on your understanding of the formulation, which formulation will dissolve faster?
Formulation A – Drug T with disintegrants, hydrophilic fillers, lubricants, glidants, and surfactants
Formulation B – Drug T with disintegrants, hydrophobic fillers, lubricants, and glidants
- Formulation A
- Formulation B
- Either formulation will have the same dissolution rate
Formulation A
The major physical stability issues with tablet is?
aging
T/F Buccal and sublingual tablets should be swallowed
false
Drug T is available as a chewable tablet and a Buccal tablet. Drug T has a MW of 638 Da, a log Ko/w of 2.1, and a pKa of 4.9. What will be the rate-limiting step for Drug T in the CHEWABLE tablet? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant
Dissolution rate
Drug T is available as a chewable tablet and a Buccal tablet. Drug T has a MW of 638 Da, a log Ko/w of 2.1, and a pKa of 4.9. What will be the rate-limiting step for Drug T in the BUCCAL tablet? Diffusion coefficient Partition coefficient Dissolution rate Permeability constant
Dissolution rate
