Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmaceutics II > Week 5/6 > Flashcards

Week 5/6 Flashcards

1
Q

Micromeritics is defined as the science of

A

small particles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q 
Particle size can affect\_\_\_\_\_\_\_\_. [Select all that apply]
appearance 
texture 
dissolution rate 
bioavailability 
diffusion 
partition
A

appearance
texture
dissolution rate
bioavailability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

By decreasing the particle size, what type of stability can be enhanced in a suspension dosage form?
physical stability
chemical stability
microbiological stability

A

physical stability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q 
Particle shape can affect\_\_\_\_\_\_\_\_. [Select all that apply]
flow 
packing 
texture 
bioavailability 
diffusion 
dissolution
A

flow
packing
texture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

A powder with an angle of repose below 35oC can be characterized as?

A

freely flowing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which physical property of the particle will most affect the rate of drug absorption?
particle size
particle shape
particle angle of repose particle porosity
particle density

A

particle size

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q 
A powder dosage form is defined as a/an?
drug powder or API 
drug powder mixed with excipients 
powder for reconstitution 
agglomeration of powders
A

drug powder mixed with excipients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q 
A granule dosage form is defined as?
drug powder or API 
drug powder mixed with excipients 
powder for reconstitution 
agglomeration of powders
A

agglomeration of powders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q 
Powders for reconstitution are made to?
increase in the shelf-life of the drug 
increase the portability of the drug 
decrease the weight of the drug product 
reduce the doses needed of the drug
A

increase in the shelf-life of the drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

T/F Dusting powders are used for systemic application

A

false

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

T/F Dusting powders must be light and fluffy to ensure their efficacy.

A

false

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drugs that typically undergo _______ are prepared by dry granulation

A

hydrolysis reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Hygroscopic drugs absorb ______ when they come into contact with water and therefore should be ______ in powder & granule dosage forms

A

moisture; avoided

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Forming different crystal forms of the drug is a sign of _______ instability in powder & granule dosage forms.

A

physical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

T/F Powder & granule dosage forms are an excellent option in extending the shelf-life of chemically unstable drugs.

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dry powder inhalers are powder dosage forms intended for the ______ route of administration

A

pulmonary

17
Q 
Drug X has a MW of 330 Da and a log Ko/w of 1.4.  It is available as a powder for a solution that the pharmacist reconstitutes before dispensing and granules for suspension.  What is the rate-limiting step for Drug X in the POWDER for the SOLUTION?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant
A

Partition coefficient

18
Q 
Drug X has a MW of 330 Da and a log Ko/w of 1.4.  It is available as a powder for a solution that the pharmacist reconstitutes before dispensing and granules for suspension. What is the rate-limiting step for Drug X in the GRANULE for SUSPENSION?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant
A

Dissolution rate

19
Q

A tablet is defined as a solid dosage form [select all that apply]

  • with drug and excipients prepared by compression
  • with drug and excipients prepared by molding
  • with drug and excipients prepared by homegenization
  • with drug and excipients prepared by blending
A

with drug and excipients prepared by compression

with drug and excipients prepared by molding

20
Q 
Match the process with its definition:
Disintegration
Deaggregation
Dissolution
Diffusion
options:
-coarse particles break up into fine particles
-desegregation of constituent particles
-solute molecules move down the concentration gradient
-a solute entering a solution
A

Disintegration: desegregation of constituent particles
Deaggregation: coarse particles break up into fine particles
Dissolution: a solute entering a solution
Diffusion: solute molecules move down the concentration gradient

21
Q

Rank the different types of tablets in terms of their dissolution rate from fastest to slowest: MR, RDT, and IR

A

RDT>IR>MR

22
Q

Which of the following types of tablets are the cheapest to manufacture?
RDT
IR
MR

A

IR

23
Q

Which of the following tablets would be best suited for chronic use?
RDT
IR
MR

A

MR

24
Q

T/F All tablets undergo compression.

A

false

25
Q 
Which type of tablet is suitable for incompatible drugs?
Sugar-coated 
Effervescent 
Compressed 
Multi-compressed
A

Multi-compressed

26
Q

How can tablets be classified based on their release rate?
RDT, IR, MR
Sugar-coated, gelatin-coated, film-coated
Buccal, sublingual, vaginal
Compressed, chewable, effervescent

A

RDT, IR, MR

27
Q

Which type of coating may be used to modify the drug dissolution rate? [Select all that apply]
Gelatin coating
Film coating
Sugarcoating

A

Film coating

28
Q 
Which type of tablet undergoes mechanical disintegration before absorption?
Chewable 
Effervescent 
Vaginal 
Buccal
A

Chewable

29
Q 
Which type of tablet(s) undergo(es) slow dissolution? [Select all that apply:
Buccal 
Sublingual 
Vaginal 
Effervescent
A

Buccal and vaginal

30
Q

What drug property is needed for incorporating the drug in tablet dosage form?
Compressible
Potent
Protein-based

A

Compressible

31
Q

Drug T has two formulations – A & B. Based on your understanding of the formulation, which formulation will dissolve faster?

Formulation A – Drug T with disintegrants, hydrophilic fillers, lubricants, glidants, and surfactants

Formulation B – Drug T with disintegrants, hydrophobic fillers, lubricants, and glidants

  • Formulation A
  • Formulation B
  • Either formulation will have the same dissolution rate
A

Formulation A

32
Q

The major physical stability issues with tablet is?

A

aging

33
Q

T/F Buccal and sublingual tablets should be swallowed

A

false

34
Q 
Drug T is available as a chewable tablet and a Buccal tablet.  Drug T has a MW of 638 Da, a log Ko/w of 2.1, and a pKa of 4.9. What will be the rate-limiting step for Drug T in the CHEWABLE tablet?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant
A

Dissolution rate

35
Q 
Drug T is available as a chewable tablet and a Buccal tablet. Drug T has a MW of 638 Da, a log Ko/w of 2.1, and a pKa of 4.9. What will be the rate-limiting step for Drug T in the BUCCAL tablet?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant
A

Dissolution rate

Pharmaceutics II (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions