Capsule Dosage Forms Flashcards
define dissolution
process by which a solute enters a solution and this is occurring continually
define Deaggregation
process by which coarse particles created by disintegration break up into fine particle
define Disintegration
process of desegregation of constituent particles before the drug dissolution occurs.
define Desiccant
a hygroscopic substance that induces or sustains a state of dryness
define Plasticizer
an excipient added to synthetic or natural polymers, like gelatin, to make the polymer pliable and soft, thereby preventing its cracking.
Capsules are a:
a. solid dosage forms where the drug & excipients are compressed into an oval shape
b. solid dosage forms where the drug & excipients are enclosed in a small shell of gelatin
c. liquid dosage forms where the drug & excipients are dissolved in a miscible vehicle
d. liquid dosage forms where the drug and excipients are suspended in an immiscible vehicle
b
As HGC capsule sizes increase the amount or volume that can be loaded _____ and as SGC capsule sizes increase the amount or volume that can be loaded _____
decreases, increases
HGC and SGC stand for?
hard gelatin capsules
soft gelatin capsules
Between HGC and SGC, Which can be manufactured and compounded?
HGC
Why is locking of HGCs important?
a. To prevent loss of drug
b. To prevent tampering
c. To prevent mixing of contents with food
d. To prevent over packing the capsules
b
Moisture content in HGC is ____ than/as SGC
lower
what is the only drug type that cannot be incorporated into capsule dosage forms?
Hygroscopic drugs
between HGC and SGC, Which type can take both solid and liquid contents?
HGC
T/F Aqueous vehicles can be used in SGCs
false
Which excipients incorporated in capsules maintain a dry state in capsule dosage forms?
a. Desiccant
b. Opacifier
c. Gelatin
d. Plasticizer
a
