Oral Modified Release Dosage Forms Flashcards
Compressed tablets are tablets that undergo ___ compression cycle
one
Enteric coated tablets have a coating designed to disintegrate in the _____
but not in the _____.
intestine
stomach
Effervescent tablets are uncoated compressed granular effervescent
salts that release ___ when in contact with ____
gas
water
define Modified Release (MR) dosage forms
any solid dosage forms that have been designed to release a drug in a pre-determined manner.
A modified release dosage from is dosage form where the rate of drug release:
a. tailored in a specific manner
b. not particularly controlled
c. tailored for a specific disease
d. driven by disintegration
a
A reason for formulating a drug as a delayed-release tablet is:
a. improves organoleptic properties
b. protects the small intestine
c. protects the drug from the stomach
d. less expensive than the IR tablet
c
T/F Once the enteric coat is removed, a delayed-release tablet will have the same dissolution profile as an immediate-release tablet with the same formulation without the delayed-release coat.
True
A repetab is this type of tablet formulation:
a. Single compressed tablet
b. Multiple compressed tablet
c. Effervescent tablet
d. Enteric-coated tablet
b
The extended-release formulation is intended to mimic a steady-state drug absorption profile through:
a. Zero-order release
b. First-order release
c. Pusedo-first-order release
d. Second- order release
a
T/F Typically extended-release formulations must disintegrate to exhibit their pharmacologic effects.
false
Characteristics of insoluble matrix systems include, they:
a. dissolve slowly to allow for drug diffusion
b. form aqueous channels to allow for drug diffusion
c. have a rate controlling membrane that allows for drug diffusion
d. push the drug out of the tablet through osmosis
b
Drugs formulated in ER dosage forms should have half-lives __________.
a. > 8 hr
b. between 2-8 hr
c. < 2 hr
b
T/F LA drugs are ideal for ER dosage forms.
false
what OTC drug should you avoid when taking DR drugs?
antacids
T/F An enteric coated tablet can be cut/crushed without dose dumping effects.
True
T/F A repetab can be cut without toxic effects.
false
T/F Buccal & SL spaces have high keratinization leading to increased permeability.
false
T/F buccals and sl tablets bypass 1st pass effect
true
T/F buccals and sl tablets can be used for local or systemic effects
true
The transport of monosaccharides and amino acids in the buccal and SL space occurs through:
a. Passive transcellular diffusion
b. Passive paracellular diffusion
c. Carrier-mediated transcellular diffusion
d. Transcellular endocytic processes
c
T/F Buccal & SL routes of administration are intended for local action
false
Which oral transmucosal route of administration allows for prolonged contact for drug delivery?
a. Buccal
b. SL
c. Hard Palate
d. Gingivae
a
What is the major advantage of using the transmucosal space for drug delivery?
a. Large absorptive surface area
b. High patient compliance
c. Bypasses first-pass metabolism
d. Intended for local action
c
T/F SL tablets are coated for rapid drug release.
false
Identify the critical excipient in SL tablets responsible for the quick onset of action through this route.
a. Super disintegrants
b. Sweeteners
c. Flavorants
d. Buffers
e. glidants
f. diluents
a
The primary barrier to SL drug delivery is _________ production , requiring drug to be absorbed quickly.
high salivary
T/F Buccal tablets need to disintegrate quickly to be bioavailable
false
Identify the critical excipient in buccal tablets responsible for the prolonged action through this route.
a. Super disintegrants
b. Sweeteners
c. Flavorants
d. mucoadhesives
e. glidants
f. diluents
d
Which of the buccal dosage forms will allow for the sustained release of the drug? [Select all that apply]
a. Lozenges
b. Tablets
c. Patches
b,c
