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Pharmaceutics II > Oral Modified Release Dosage Forms > Flashcards

Oral Modified Release Dosage Forms Flashcards

1
Q

Compressed tablets are tablets that undergo ___ compression cycle

A

one

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2
Q

Enteric coated tablets have a coating designed to disintegrate in the _____
but not in the _____.

A

intestine

stomach

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3
Q

Effervescent tablets are uncoated compressed granular effervescent
salts that release ___ when in contact with ____

A

gas

water

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4
Q

define Modified Release (MR) dosage forms

A

any solid dosage forms that have been designed to release a drug in a pre-determined manner.

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5
Q

A modified release dosage from is dosage form where the rate of drug release:

a. tailored in a specific manner
b. not particularly controlled
c. tailored for a specific disease
d. driven by disintegration

A

a

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6
Q

A reason for formulating a drug as a delayed-release tablet is:

a. improves organoleptic properties
b. protects the small intestine
c. protects the drug from the stomach
d. less expensive than the IR tablet

A

c

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7
Q

T/F Once the enteric coat is removed, a delayed-release tablet will have the same dissolution profile as an immediate-release tablet with the same formulation without the delayed-release coat.

A

True

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8
Q

A repetab is this type of tablet formulation:

a. Single compressed tablet
b. Multiple compressed tablet
c. Effervescent tablet
d. Enteric-coated tablet

A

b

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9
Q

The extended-release formulation is intended to mimic a steady-state drug absorption profile through:

a. Zero-order release
b. First-order release
c. Pusedo-first-order release
d. Second- order release

A

a

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10
Q

T/F Typically extended-release formulations must disintegrate to exhibit their pharmacologic effects.

A

false

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11
Q

Characteristics of insoluble matrix systems include, they:

a. dissolve slowly to allow for drug diffusion
b. form aqueous channels to allow for drug diffusion
c. have a rate controlling membrane that allows for drug diffusion
d. push the drug out of the tablet through osmosis

A

b

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12
Q

Drugs formulated in ER dosage forms should have half-lives __________.

a. > 8 hr
b. between 2-8 hr
c. < 2 hr

A

b

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13
Q

T/F LA drugs are ideal for ER dosage forms.

A

false

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14
Q

what OTC drug should you avoid when taking DR drugs?

A

antacids

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15
Q

T/F An enteric coated tablet can be cut/crushed without dose dumping effects.

A

True

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16
Q

T/F A repetab can be cut without toxic effects.

A

false

17
Q

T/F Buccal & SL spaces have high keratinization leading to increased permeability.

A

false

18
Q

T/F buccals and sl tablets bypass 1st pass effect

A

true

19
Q

T/F buccals and sl tablets can be used for local or systemic effects

A

true

20
Q

The transport of monosaccharides and amino acids in the buccal and SL space occurs through:

a. Passive transcellular diffusion
b. Passive paracellular diffusion
c. Carrier-mediated transcellular diffusion
d. Transcellular endocytic processes

A

c

21
Q

T/F Buccal & SL routes of administration are intended for local action

A

false

22
Q

Which oral transmucosal route of administration allows for prolonged contact for drug delivery?

a. Buccal
b. SL
c. Hard Palate
d. Gingivae

A

a

23
Q

What is the major advantage of using the transmucosal space for drug delivery?

a. Large absorptive surface area
b. High patient compliance
c. Bypasses first-pass metabolism
d. Intended for local action

A

c

24
Q

T/F SL tablets are coated for rapid drug release.

A

false

25
Q

Identify the critical excipient in SL tablets responsible for the quick onset of action through this route.

a. Super disintegrants
b. Sweeteners
c. Flavorants
d. Buffers
e. glidants
f. diluents

A

a

26
Q

The primary barrier to SL drug delivery is _________ production , requiring drug to be absorbed quickly.

A

high salivary

27
Q

T/F Buccal tablets need to disintegrate quickly to be bioavailable

A

false

28
Q

Identify the critical excipient in buccal tablets responsible for the prolonged action through this route.

a. Super disintegrants
b. Sweeteners
c. Flavorants
d. mucoadhesives
e. glidants
f. diluents

A

d

29
Q

Which of the buccal dosage forms will allow for the sustained release of the drug? [Select all that apply]

a. Lozenges
b. Tablets
c. Patches

A

b,c

Pharmaceutics II (9 decks)

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