Transdermal DDS Flashcards
What type of drug delivery system would you want to use for systemic drug delivery only? [Select all that apply]
a. topical ointment
b. transdermal ointment
c. topical patch
d. transdermal patch
b,d
T/F Dosing for patches is based on the size of the patch as it relates to the area of application
true
Transdermal patches that can be cut is/are_______. [Select all that apply]
a. Matrix
b. Reservoir
c. Transdermal patches cannot be cut
a
T/F Transdermal patches contain an excessive amount of the drug to achieve zero-order release
true
Removal of a transdermal patch __ drug absorption, as the stratum corneum ___ as secondary reservoir
stop
acts
JK was given a Daytrana patch to wear for 9 hours per day. It is a transdermal delivery system for methylphenidate. She has been taking it for 6 months. The patient was warned not to apply external heat to the patch. She forgot this rule and used a heating pad over the application area due to sore muscles from sports practice. She is now feeling sick. What happened?
a. Warm skin is more permeable to the drug & she may be suffering from an overdose.
b. The patient is not used to the drug, and this is entirely normal
c. The patient may have developed a drug allergy-like anaphylaxis
a
Two months later, JK calls back, feeling ill again. She typically applies the patch at 8 AM and removes it at 5 PM. Last night, she forgot to remove it after work, slept in it, then used a second patch in the morning. She removed both patches at 10 AM as soon as she remembered. She is wondering what she should do. She feels very ill.
a. Call the physician immediately. She is suffering from an overdose.
b. Removing the patches should solve the problem. She will be fine within minutes.
c. Wash the area to remove the excess drug, and the problem will resolve immediately after washing.
a
Is removing the patch solve JK’s problems immediately? Why/why not?
a. Yes – because the patches are off her skin, the problem will rapidly resolve itself.
b. No – the SC acts as a second reservoir, and the drug will continue to release from the SC tissue over time.
b
Targeted transdermal systems utilized which of the following mechanism to allow for systemic macromolecular drug delivery?
a. By passing the epidermis
b. By passing the dermis
c. By passing the stratum corneum
d. By passing the subcutaneous space
c
Which of the following transdermal delivery systems physically breach the SC?
a. Iontophoresis
b. Matrix patch
c. Microneedles
d. Penetration enhancers
c
