Week 4

Question 1

A suspension is defined as a [Select all that apply]
solid dispersed in an immiscible liquid
liquid dispersed in an immiscible liquid
solid dispersed in a gas or volatile propellant
liquid dispersed in a gas or volatile propellant

Answer 1

solid dispersed in an immiscible liquid

solid dispersed in a gas or volatile propellant

Question 2

Suspensions can be characterized based on______________. [Select all that apply]
their dispersion medium
the size of the dispersed particles
the viscosity of the external phase
the route of administration
the electrokinetic nature of the dispersed particles

Answer 2

their dispersion medium
the size of the dispersed particles
the route of administration
the electrokinetic nature of the dispersed particles

Question 3

The zeta potential is optimized in a ______ suspension

Answer 3

flocculated

Question 4

Colloidal suspensions have dispersed phase sizes that are?

Answer 4

less than 1 um

Question 5

The dominant force in flocculated suspensions is _____ due to the _____ size of the flocs

Answer 5

gravity; larger

Question 6

T/F Ready to use suspensions have drugs with low chemical stability.

Answer 6

false

Question 7

T/F Suspensions can mask the bitter taste of drugs better than solutions.

Answer 7

true

Question 8

A lipophilic drug delivered in a suspension requires ________ external phase of the formulation

Answer 8

aqueous-based

Question 9

Which excipient in a suspension dosage form will promote the formation of flocs?
Preservative 
Wetting agent 
Particulate hydrocolloid 
Thickening agent

Answer 9

Particulate hydrocolloid

Question 10

The purpose of a wetting agent in a suspension is to?

Answer 10

reduce interfacial tension

Question 11

Which type of electrokinetic suspension will form a loose fluffy sediment that will re-disperse easily? [Select all that apply]
Deflocculated suspension
Flocculated suspension
Flocculated suspension in a structured vehicle
Deflocculated suspension in a structured vehicle

Answer 11

Flocculated suspension

Flocculated suspension in a structured vehicle

Question 12

The incorporation of a structured vehicle in a suspension enhances its stability by?

Answer 12

reducing the rate of settling

Question 13

Irreversible physical stability issues with suspensions include\_\_\_\_\_\_\_\_\_\_\_. [Select all that apply]
flocculation 
caking 
crystallization 
coalescence

Answer 13

caking and crystallization

Question 14

T/F Suspensions are prone to chemical instabilities and cannot be used with chemically unstable drugs

Answer 14

false

Question 15

T/F Coarse suspensions can be administered parenterally by the IV route

Answer 15

false

Question 16

Drug S is available as an aqueous suspension. Drug S has a MW of 512 Da and a log Ko/w of 1.  What will be the rate-limiting step for Drug S in this dosage form?
Diffusion coefficient 
Partition coefficient 
Dissolution rate 
Permeability constant

Answer 16

Dissolution rate

Question 17

A semisolid is defined as a:
solid dispersed in an immiscible liquid.
liquid dispersed in an immiscible liquid.
solid dissolved in a miscible liquid.
neither a solid nor a liquid dosage form.

Answer 17

neither a solid nor a liquid dosage form.

Question 18

Semisolid inserts for rectal, vaginal or urethal drug delivery are called?

Answer 18

suppositories

Question 19

Ointment bases include\_\_\_\_\_\_\_\_\_\_\_\_\_. [Select all that apply] 
hydrocarbon 
water-removable 
gels 
pastes

Answer 19

hydrocarbon

water-removable

Question 20

Semisolid bases that can be used to incorporate drugs that hydrolyze are \_\_\_\_\_\_. [Select all that apply]
gels 
water-soluble 
absorption 
water-removable 
hydrocarbon

Answer 20

absorption

hydrocarbon

Question 21

Which of the following bases can pull water and irritate the mucosa.?
Hydrocarbon 
Water-soluble 
Gel 
Pastes

Answer 21

Water-soluble

Question 22

Semisolid base(s) that are occlusive include. [Select all that apply]
hydrocarbon 
anhydrous 
water-removable 
water-soluble 
gel

Answer 22

hydrocarbon

anhydrous

Question 23

Which semisolid dosage forms can only be used for the oral cavity? 
lozenges 
creams 
lotions 
ointments

Answer 23

lozenges

Question 24

T/F Ideal drug candidates for semisolid preparation are large, hydrophilic molecules.

Answer 24

false

Question 25

What type of a base would you recommend for a patient with dry skin?
Hydrocarbon 
Water-removable 
Gel 
Paste

Answer 25

Hydrocarbon

Question 26

What type of an excipient would you incorporate in a semisolid formulation for a patient with serous discharge or secretion?
Preservative 
Humectant 
Astringent 
Emollient

Answer 26

Astringent

Question 27

What type of a base would you recommend for the fast release of a hydrophilic drug?
Hydrocarbon 
Water-removable 
Gel 
Paste

Answer 27

Hydrocarbon

Question 28

What type of formulation would you recommend for chronic use to minimize the number of times an ointment needs to be applied?
Drug suspended in the base.
Drug dissolved in the base.
Either drug suspended or dissolved. in the base

Answer 28

Drug suspended in the base.

Question 29

The purpose of a levigating agent in a semisolid is to\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
reduce interfacial tension 
increase viscosity 
optimize the zeta potential 
reduce the particle size

Answer 29

reduce the particle size

Question 30

Which type of semisolid preparation will experience bleeding issues? [Select all that apply]
Ointments with hydrocarbon bases 
Ointments with absorption bases 
Ointments with water-removable bases 
Ointments with water-washable bases 
Semisolids with gel bases

Answer 30

Ointments with absorption bases

Ointments with water-removable bases

Question 31

Drying of the semisolid preparation will most likely be seen in which of the following semisolids bases? [Select all that apply]
Hydrocarbon base. 
Gel base. 
Absorption base. 
Water-slouble base.

Answer 31

Gel base.

Question 32

T/F Semisolid preparations applied to various regions in the body are intended for local effect.

Answer 32

false

Question 33

Drug T has a MW of 290 Da, log Ko/w of 2.5.  It is available as Drug T suspension in a hydrocarbon base, and Drug T dissolved in a gel base. What will be the rate-limiting step for Drug T in the hydrocarbon base?
Diffusion coefficient. 
Partition coefficient. 
Dissolution rate. 
Permeability constant.

Answer 33

Partition coefficient.