Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmaceutics II > Week 1/2 > Flashcards

Week 1/2 Flashcards

1
Q

Based on the description provided, “Inhaled Albuterol Sulfate Suspension,” answer the following questions:
The drug is?
The dosage form is?
The route of administration is?

A

albuterol sulfate
suspension
pulmonary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Based on your understating of dosage forms, categorize the following dosage forms/ formulations as solid, liquid, or semi-solid.

  1. Emulsions
  2. Pastes
  3. Granules
A

liquids
semisolids
solids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Excipients which control the rate of drug release impact the drug’s

A

rate of absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which type of excipient is critical for an orally administered acid-sensitive drug?

A

Buffering agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How quickly to effervescent tablets dissolve compared to regular tablets?

A

faster

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q 
Based on your understanding of dosage forms which of the excipients would you expect in a liquid dosage form? {Select all that apply}
Emulsifying agent 
Lubricant 
Vehicle 
Sweeting agent
A

Emulsifying agent
Vehicle
Sweeting agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q 
Based on your understanding of dosage forms, which excipients would you expect in a semisolid dosage form? {Select all that apply}
Levigating agent 
Lubricants 
Vehicle 
Ointment base
A

Levigating agent

Ointment base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q 
Based on your understanding of dosage forms, which excipients would you expect in a solid dosage form? {Select all that apply}
Glidant 
Lubricants 
Vehicle 
Film coating
A

Glidant
Lubricants
Film coating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T/F Excipients listed in the Inactive Ingredients Database can be incorporated into all dosage forms without any additional considerations

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

T/F Excipients that can increase the rate of absorption aid with the disintegration of solid dosage forms.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The major pathway of absorption for small hydrophilic molecules (MW <300 Da) is?

A

passive paracellular diffusion.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The major pathway of absorption for small lipophilic drugs (<1000 Da) is

A

passive transcellular diffusion.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The major pathway for most drug absorption is passive ______ transport.

A

transcellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T/F Drugs which are slightly hydrophobic will have higher drug absorption than very hydrophilic or very hydrophobic drugs

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

As the molecular weight of a molecule increases its diffusion coefficient, _____

A

decreases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

As the radius of a molecule decreases its diffusion coefficient, _____

A

increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

As the viscosity of a medium increases, the diffusion coefficient of a molecule in that medium, _____

A

decreases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

As the temperature increases the, diffusion coefficient of a molecule, ______

A

increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

As the molecular weight increases the, molecular size, _____

A

increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

If a drug has a high partition coefficient, it is lipophobic or liphophilic?

A

Lipophilic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

For an API absorption, the ideal range for log Ko/w or log Po/w is between?

A

1 to 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

A drug has a partition coefficient of 0.333. Its log partition coefficient value is?

A

-0.478 (figure out how to calculate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

A log Ko/w or log Po/w value of 2 indicates that the drug molecule is?

A

lipophilic

24
Q

A log Ko/w or log Po/w value of -3 indicates that the drug molecule is?

A

hydrophilic

25
Q

A log Ko/w or log Po/w value of 0 indicates that the drug molecule is?

A

equally lipohilic and hydrophilic

26
Q

A drug has log Po/w value of 2.699 indicating that; (select that all apply)
the solubility ratio of the drug in oli/water is ≈ 500.
the solubility ratio of the drug in oil/water is ≈ 0.431.
the drug is lipophilic.
the drug is hydrophilic.

A

the solubility ratio of the drug in oli/water is ≈ 500.

the drug is lipophilic.

27
Q

What happens to the permeability of a molecule if the MW of the compound increases?

A

Permeability decreases

28
Q

What happens to the permeability of a molecule if the partition coefficient increases?

A

Permeability increases

29
Q

What happens to the flux of a molecule across biological membrane if its permeability decreases?

A

Flux decreases

30
Q

What happens to the flux of a molecule across the biological membrane if the molecule concentrations C0 and Ci are equal?

A

Flux stops

31
Q

define Molecular dispersion

A

homogenous, dispersant size less than 1nm

32
Q

define Colloidal dispersion

A

non-homogwnous, dispersant size 1nm to 1um

33
Q

define Coarse dispersion

A

non-homogwnous, dispersant size greater than 1um

34
Q

Components of a solution include a ____ completely ____ in a _____
key: solvent, solute, dissolved

A

solute, dissolved, solvent

35
Q

Increasing the dissolution rate:

  • increases solubility
  • decreases solubility
  • dose not affect solubility
A

dose not affect solubility

36
Q

A compound that is sparingly soluble has an approximate solubility of:

  • 33 – 100 mg/mL
  • 10 – 33 mg/mL
  • 1 – 10 mg/mL
A

10 – 33 mg/mL

37
Q

Ionized forms of the drug have ____ aqueous solubility compared to the unionized form of the drug molecule.

A

higher

38
Q

Salt forms of the drug have ____ aqueous solubility compared to the weak electrolyte form of the drug molecule.

A

higher

39
Q

Different salt forms of the drug have _____ aqueous solubility compared to the weak electrolyte form of the drug molecules.

A

different

40
Q

Neutral molecules need co-solvents, surfactants, or non-aqueous formulations due to their ____ aqueous solubility

A

lower

41
Q

The crystalline form of the drug will have ____ solubility compared to the amorphous form of the drug.

A

lower

42
Q

Typically, solubility of solid solutes in liquid solvents _____ with increasing temperature.

A

increases

43
Q

Aqueous water-based solutions can be administered by __ routes of administration.

A

all

44
Q

Aqueous syrups contain:

  • 100% water and up to 100% sugar
  • 100% water and up to 85% sugar
  • 100% alcohol and up to 85% sugar
  • 100% alcohol and up to 100% sugar
A

100% water and up to 85% sugar

45
Q

Elixirs contain:

  • 60-95% water & 5 - 40% alcohol
  • 60-95% alcohol & 5 - 40% water
  • 60-95% oil & 5 - 40% alcohol
  • 60-95% alcohol & 5 - 40% oil
A

60-95% water & 5 - 40% alcohol

46
Q

Elixirs can be administered by ________ route(s) of administration.

A

oral & topical

47
Q

Oil solutions contain ___ oil.

A

100%

48
Q

Oil solutions can be administered by what route(s) of administration?

A

IM, topical & ophthalmic

49
Q

Which of the following vehicles can be used by all routes of administration?

  • Collodion
  • Water
  • Tincture
  • Syrup
A

water

50
Q

Drug X is available in two forms with the following aqueous solubilities: slightly soluble WA or a soluble Na salt of the WA.
Which form of the drug is most appropriate for an aqueous solution dosage form?

A

Na salt of WA

51
Q

Drug X is available in two forms with the following aqueous solubilities: slightly soluble WA or a soluble Na salt of the WA.
Which form of the drug is most appropriate for an oil based solution dosage form?

A

WA

52
Q 
Drug X is very slightly soluble with a log Ko/w 2.2 and a MW of 420 Da. No salt forms of Drug X are available.  Based on its solubility each dose will require 8 tablespoons.  What option(s) should you consider if Drug X needs to be formulated as an aqueous solution? [Select all that apply.]
Use a co-solvent 
Use a surfactant 
Use a complexing agent 
Use an oil vehicle
A

Use a surfactant

Use a complexing agent

53
Q

Which of the following excipients will you expect in a topical solution? [Select all that apply.]

  • Vehicle
  • Surfactants/complexing agents/ co-solvents
  • Preservatives
  • Sweeteners
A

Vehicle
Surfactants/complexing agents/ co-solvents
Preservatives

54
Q

The chemical stability of drugs in solution dosage forms can be improved by making?

  • aqueous solutions
  • powders for reconstitution
  • hydro-alcoholic solutions
A

powders for reconstitution

55
Q

Drug S is available as an aqueous solution. Drug S has a MW of 420 Da and a log Ko/w of -3.5. What will be the rate limiting step for Drug S in this dosage form?

  • Diffusion coefficient
  • Partition coefficient
  • Both diffusion coefficient & partition coefficient
  • Neither diffusion coefficient & partition coefficient
A

Partition coefficient

Pharmaceutics II (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions