Week 4 high yield buzzwords Flashcards
1
Q
Benzene exposure:
A
Secondary AML
2
Q
inv(16):
A
APML
3
Q
11q23
A
monocytic AML
4
Q
t(15;17)
A
AML M3
5
Q
Don’t let the sun set on…..
A
AML M3
6
Q
CD5+
CD19+
CD20+
CD23+
A
CLL
7
Q
CD5+
CD23-
cyclin D1+
A
Mantle cell lymphoma
8
Q
ZAP-70+
A
Ig Vh mutation – poor prognosis
CLL
9
Q
13q-
A
Smudge cell CLL
10
Q
Parvovirus on DDx
A
red cell aplasia
11
Q
High L-selectin and CCR7
A
Naive CTL-P in lymph node
12
Q
High CD44 and LFA-1
A
Effector CTL
13
Q
LFA-1 binds:
A
ICAM
14
Q
CD56-low
A
CTL w/granules – best killer
15
Q
CD56-high
A
CTL w/o granules – release cytokines (INF-y)
16
Q
CD16 (FcyRIIIA), NKRs
A
NK cells
17
Q
NKG2A (CD94)
A
NK cell inhibitory receptor
**trumps everything
18
Q
KIR2DS1
A
NK cell activating receptor
19
Q
Basophilia
A
CML
20
Q
Philadelphia chromosome
A
CML
21
Q
Neutrophilic leukocytosis
A
CML
22
Q
t(9;22)
A
CML
BCR-ABL
Philadelphia
23
Q
Jak-2
A
Polycythemia vera
24
Q
Plethora (flushing)
A
Polycythemia vera
25
High Platelets in YOUNG WOMEN:
Essential Thrombocythemia
26
Teardrop RBCs
Chronic Myelofibrosis
27
LUQ fullnes
Chronic myelofibrosis
HUGE spleen
28
BCR-ABL
CML
29
Wnt-B catenin
CML Blast phase
30
CEBPa
promotes myeloid differention
**blocked in CML Blast phase
31
Coil-coil domain/ tyrosin 177
BCR
32
Myristate
ABL
inhibitory
lost in CML
33
Stat5
transcription factor acting w/o GM-CSF signaling in CML
34
BCR-ABL specific tyr-kinase inhibitor
Imatinib
CML
35
Osteolytic lesions
Multiple myeloma
36
Bence-Jones proteins
Multiple Myeloma
37
Rouleaux
Multiple Myeloma
38
Amyloid in BM
Multiple Myloma
39
Flame cells
multiple myeloma
40
Russel bodies
multiple myeloma
41
Dutcher bodies
multiple myeloma
42
Mott cells
multiple myeloma
43
Plasma cell tumor with IgM
Retinal involvement
Waldenstrom macroglobulinemia
44
anemia
bone pain
renal failure
multiple myeloma
45
small, mature lyphocytes
CLL
46
B-cells w/CD5+
CLL
47
bcl-2
CLL
immortalizes cells
48
TRAP+
Hairy cell Leukemia
49
CD25+
CD11c+
CD5-
Hairy Cell Leukemia
50
Slepomegaly without lymphadenopathy
Hairy cell
Prolymphocytic
51
Large granulated lymphocytes
T-cell
| Large granulated lymphocyte leukemia
52
Tingible body macrophages
Follicular Hyperplasia
Burkitt Lymphoma
53
Partial effacement
Interfollicular Hyperplasia
54
Small lymphocitic lymphoma
CLL
55
H. pylori
MALT lymphoma
56
t(11;14)
Mantle Cell Lymphoma
57
t(14;18)
Follicular lymphoma
58
butt cels
Follicular lymphoma
59
paratrabecular aggregate
Follicular lymphoma
60
Cerebriform lymphocytes
Mycosis fungoides
61
Psorias looking
Mycosis fungoides
62
Pautrier microabscess
Mycosis fungoides
63
Large B-cells
Diffuse Large cell Lymphoma
64
Teenage male with mediastinal mass
Lymphoblastic lymphoma
| same as ALL
65
t(8;14)
Burkitt Lymphoma
66
Starry-sky pattern
Burkitt lymphoma
67
HTLV-1
Adult T-cell Leukemia/lymphoma
68
Reed-Sternberg cell
Hodgkin Lymphoma
69
Popcorn cells
Nodular Lymphocytic-Predominance Hodgkin Lymphoma
70
Lacunar cells
Nodular Sclerosis Hodgkin Lymphoma
71
Collagen/reticulin background
Lymphocyte depletion Hodgkin Lymphoma
72
Lung disease (drug)
Bleomycin
73
anti-CD20 drug
Rituximab
