Non-Hodgkin Lymphoma

Question 1

Most common cause of lymphadenopathy?

Answer 1

benign reaction to infection

Question 2

Most common malignant cause of lymphadenopathy?

Answer 2

metastatic carcinoma

Question 3

Large, irregular lymph node follicles

mixture of cells in germinal center

Tingible body macrophages

B-cell response to some immune stimulus

Answer 3

Follicular hyperplasia

Question 4

Partial effacement of follicles. Think:

Answer 4

benign, Interfollicular hyperplasia

Question 5

4 things you must know about NHL:

Answer 5

malignant proliferation of lymphoid cells (blasts OR mature) in lymph nodes

skips around–non-contiguous spread from node to node

many subtypes

most are B-cell

Question 6

Symptoms of NHL:

Answer 6

PAINLESS, firm (but not rock hard like carcinoma) lymphadenopathy

extranodal manifestations

“B” symptoms: weight loss, night sweats, fever – indicate worse prognosis

Question 7

Grade of NHL characterized by:

older patients

Indolent (incurable)

small, mature cells

non-destructive

Answer 7

Low-grade

Question 8

Grade of NHL characterized by:

children, sometimes

aggressive (curable? maybe because more rapidly dividing cells)

BIG, UGLY cells

Destructive

Answer 8

High-grade

Question 9

Four types of Low-grade NHL:

Answer 9

1. Small lymphocytic lymphoma (SLL)
2. Malt lymphoma
3. Follicular lymphoma
4. Mycosis fungoides

Question 10

Three types of High-grade NHL:

Answer 10

1. Large cell lymphoma
2. Lymphoblastic lymphoma
3. Burkitt lymphoma

Question 11

Same as CLL

Small MATURE lymphocytes

B-cells, but CD5+

long course, death from infection

Answer 11

Small Lymphocytic Lymphoma

Question 12

H. pylori associated with:

Answer 12

Malt lymphoma

Question 13

Chromosomal translocation associated with Mantle cell lymphoma?

Answer 13

t(11;14)

Question 14

Small angulated lymphocytes, think:

Answer 14

Mantle cell lymphoma

**surrounds small, benign germinal center

Question 15

Small cleaved cell, mixed or large cell

Grade 1, 2, 3

t(14;18)

most common along with CLL/SLL

Answer 15

Follicular lymphoma

Question 16

Blood smear “butt cells” mean……

Answer 16

Follicular lymphoma

Question 17

Paratrabecular aggregation in BM means?

Answer 17

Follicular lymphoma

Question 18

Cerebriform associated with?

Answer 18

Mycosis fungoides aka Sezary Syndrome

Question 19

Immunophenotype of Mycosis fungoides?

What else has the same?

Answer 19

T-cell

**Large Granulocyte Leukemia

Question 20

Besides the lymph nodes, what other tissues are involved in Mycosis fungoides?

Answer 20

Skin (lesions) – can be mistaken for psoriasis at first

Blood

Question 21

Pautrier micro abscess = ?

Answer 21

Mycosis fungoides

Question 22

Large B-cells

Extranodal involvement

Grows rapidly

Bad prognosis

Answer 22

Diffuse Large-Cell Lymphoma

Question 23

Same as ALL?

Often in teenage male with mediastinal mass

can be B or T

Answer 23

LymphoBLASTic lymphoma

Question 24

Starry-sky pattern

Answer 24

Burkitt Lymphoma

Question 25

Child with fast growing, extranodal mass (mastoid, abdomen) t(8;14)

Answer 25

Burkitt Lymphoma **same as Burkitt Leukemia

Question 26

HTLV-1 virus Skin lesions, hypercalcemia Very aggressive Japan/Carribean

Answer 26

Adult T-cell Leukemia/Lymphoma