Non-Hodgkin Lymphoma Flashcards
Most common cause of lymphadenopathy?
benign reaction to infection
Most common malignant cause of lymphadenopathy?
metastatic carcinoma
Large, irregular lymph node follicles
mixture of cells in germinal center
Tingible body macrophages
B-cell response to some immune stimulus
Follicular hyperplasia
Partial effacement of follicles. Think:
benign, Interfollicular hyperplasia
4 things you must know about NHL:
malignant proliferation of lymphoid cells (blasts OR mature) in lymph nodes
skips around–non-contiguous spread from node to node
many subtypes
most are B-cell
Symptoms of NHL:
PAINLESS, firm (but not rock hard like carcinoma) lymphadenopathy
extranodal manifestations
“B” symptoms: weight loss, night sweats, fever – indicate worse prognosis
Grade of NHL characterized by:
older patients
Indolent (incurable)
small, mature cells
non-destructive
Low-grade
Grade of NHL characterized by:
children, sometimes
aggressive (curable? maybe because more rapidly dividing cells)
BIG, UGLY cells
Destructive
High-grade
Four types of Low-grade NHL:
- Small lymphocytic lymphoma (SLL)
- Malt lymphoma
- Follicular lymphoma
- Mycosis fungoides
Three types of High-grade NHL:
- Large cell lymphoma
- Lymphoblastic lymphoma
- Burkitt lymphoma
Same as CLL
Small MATURE lymphocytes
B-cells, but CD5+
long course, death from infection
Small Lymphocytic Lymphoma
H. pylori associated with:
Malt lymphoma
Chromosomal translocation associated with Mantle cell lymphoma?
t(11;14)
Small angulated lymphocytes, think:
Mantle cell lymphoma
**surrounds small, benign germinal center
Small cleaved cell, mixed or large cell
Grade 1, 2, 3
t(14;18)
most common along with CLL/SLL
Follicular lymphoma
