Chronic Lymphocytic Leukemia

Question 1

Adults, kids, or both?

Answer 1

Adults ONLY

Question 2

4 things you must know!

Answer 2

Small, MATURE lymphocytes

same as SLL (small lymphocytic lymphoma)

B-cell, but CD5+ (weird, usually a T-cell marker)

Long but inexorable course

Question 3

Clinical findings in CLL?

Answer 3

age > 40

asymptomatic at first

later, organ infiltration

Question 4

Cell markers that will be positive in CLL?

Answer 4

B-cell antigens (ie. CD19, 20, 21)

CD5+ !!!!!!

Question 5

Negative marker to differentiate from lymphoblastic?

Answer 5

no TdT in CLL

Question 6

lab findings in CLL?

Answer 6

increased WBC

Hypogammaglobulinemia

Question 7

genetic mutation associated with CLL:

Answer 7

bcl-2

Question 8

What dose a mutated bcl-2 do?

Answer 8

makes cells immortal

Question 9

Splenomegaly withOUT lymphadenopathy

Pancytopenia

TRAP+

Answer 9

Hairy Cell Leukemia

**obviously have hairy cells present too

Question 10

Male:Female prevalence in HCL?

Answer 10

5:1 — significantly more males

Question 11

Surface markers present in HCL?

HCL negative for?

**this is on the test probably

Answer 11

+B-cell antigens

+CD25

+CD11c

**NO CD5

Question 12

Lab finding ALWAYS present in HCL?

Answer 12

Monocytopenia

Question 13

4 things you must know about Prolymphocytic Leukemia:

Answer 13

Prolymphocytes

Splenomegaly withOUT lymphadenopathy

Rare

Aggressive

Question 14

Lab findings in Prolymphocytic Leukemia:

Answer 14

Increased WBC

decreased Hgb

decerased Plts

Question 15

Four things you must know about Large Granulated Lymphocyte Leukemia:

Answer 15

Large granulated lymphocytes

T-cell

Neutropenia

Long survival

Question 16

Clinical findings in LGL?

Answer 16

Infections from neutropenia

Long survival

Question 17

Immunophenotype of LGL?

Answer 17

T-cell