Antigen presentation and processing Flashcards
Protein heterodimer complex that transports cytosolic peptides into the lumen of the ER for loading onto MHC I’s.
TAP1/TAP2
Inside the ER lumen. Helps load peptide onto MHC:
ERAAP
Temporary binder of MHC I (alpha-microglobulin) until B2-microglobulin comes by to bind and get ready for peptide loading.
Calnexin
Sort of place holder for peptide in MHC II during synthesis in the ER. A fragment of it that remains bound after leaving the Golgi is called CLIP.
The invarient chain
Remnant of the invariant chain bond to MHC II. Removed by HLA-DO and HLA-DM:
CLIP
A nonclassical class II MHC required for antigen/CLIP exchange:
HLA-DO
Regulated by HLA-DO:
HLA-DM
Which APCs must be activated to display MHC II?
Macrophages
Why are dendrites the best APCs?
The constitutively express MHC II and B7 (CD80/86) and other co-stimulatory molecules
Must be activated to express MHC II and co-stim molecules?
Macrophages
Constitutively express MHC II but must be activated to express co-stim molecules?
B-cells
What cell is CD40L found on? What does is do?
Th’s, “licenses” dendrites to cross present
What cell is CD40 on? What does is do?
Dendrites, binds with CD40L on T helpers and allows dendrite to cross present
Normal CD4:CD8 ratio?
2:1
Autosomal RECESSIVE
presents in early infancy
low CD4+
increased susceptibility to infection
MHC II deficiency
