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IHO week 4 > Antineoplastics VI > Flashcards

Antineoplastics VI Flashcards

1
Q

Size reached when a tumor must develop a blood supply?

A

1-2 mm in diameter

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2
Q

Rebound angiogenesis is associated with stopping what drug?

A

Bevaciximab

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3
Q

VEGF inhibitor?

A

Bevacizumab

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4
Q

Inhibitors of VEGF-R and PDGF-R?

A

Pazopanib

Sorafenib

Sunitinib

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5
Q

FGF inhibitor?

A

Thalidomide/Lenolinomide

Interferon

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6
Q

mTor inhibitors?

A

Everolimus

Temsiroliumus

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7
Q

Side effects of Bevacizumab?

A

GI perforation

wound dihiscence

worsen CAD?

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8
Q

Blocks Raf?

A

SoRAFenib

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9
Q

Blocks c-KIT?

A

Pazopanib

Sunitinib

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10
Q

What is c-KIT?

A

oncogenic tyrosine kinase

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11
Q

Two reasons to think about drug-drug interactions with STI’s (pazopanib, sorafinib, sunitinib)?

A

highly plasma protein bound

CYP3A4 metabolism

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12
Q

Specific toxicity for Pazopanib:

A

severe hepatotoxicity

QT prolongation–torsades de points

GI perforation

Hypertension

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13
Q

Specific Toxicity for Sorafenib?

A

hemorrhage

HTN

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14
Q

Specific toxicity for sunitinib?

A

skin discoloration, hand-foot syndrome

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15
Q

How do mTor inhibitors reduce cell growth and proliferation?

A

Everolimus, Temsirolimus

  • mTor regulates synthesis of cyclin D1 which controls progression through G1/S phase checkpoint
  • mTor increases expression of amino acid and glucose transporters involved in glycolysis to produce ATP
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16
Q

How do mTor inhibitor affect angiogenesis?

A

Everolimus, Temsirolimus

-decrease synthesis and release of angiogenic growth factors (VEGF, PDGF)

17
Q

Pharmacokinetics of Everolimus, Temsirolimus?

A

CYP3A4 metabolism

**substrate for P-glycoprotein—>MDR

18
Q

Toxicities of Everolimus, and Temsirolimus?

A

Hypersensitivity

increased risk of lymphoma

angioedema

kidney arterial and venous thrombosis

delays in wound healing

hyperlipidemia

nephrotoxicity and proteinuria

male infertility

19
Q

Drug that causes phocomelia (short limbs):

A

Thalidomide

20
Q

Read website and try to figure out regimen chart on last PPT slide.

A

Read up.

IHO week 4 (13 decks)

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