Lymphoma Cases Flashcards by Weston Tardy | Brainscape

Q

What gives lymphoma staging a “B”?

A

> 10% weight loss

DRENCHING night sweats

fever > 38.5

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Q

What type of biopsy is required for dx?

A

Excisional

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Q

What makes up the bulk of the tumor in Hodgkin Lymphoma?

A

Reactive tissue (surrounding cancer cells)

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Q

How does HL typically present?

A

enlarging, rubbery, NON-tender nodes

usually in neck and chest

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Q

Main subtype of HL to think about?

A

Nodular sclerosis

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Q

Ann Arbor staging for Lymphomas?

A

I. single lymph node

II. one side of diaphragm

III. both sides of diaphragm

IV. Disseminated (non-lymphnode involvement)

**also add A or B depending on presence of “B” sx

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Q

Late effects possible with HL chemo?

A

secondary malignancy

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Q

Immunochemistry for HD?

**on boards

A

CD15+

CD30+

EBER+

CD20-

CD79-

CD45-

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Q

Effaced lymph node with CD19+, CD20+, CD5-, CD23-?

A

DLBCL

Diffuse large B cell lymphoma

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Q

IPI scoring system for NHL?

A

1-5 point, 1 point each for:

Age over 60

Stage III/IV

ECOG PS 3 or 4 (really sick)

Elevated LDH

Two or more extranodal sites

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Q

Prototype aggressive NHL?

A

DLBCL

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Q

Anti-CD20 gamechanger in B-cell lymphoma?

A

rituximab

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Q

t(14;18) ?

A

Follicular lymphoma

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Q

Most common INDOLENT NHL?

A

Follicular

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Q

Is Follicular Lymphoma curable with chemo?

A

no

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Q

Chromosome 14 is associated with?

A

IgH (heavy chain)

Q

Chromosome 18 is associated with?

A

bcl-2 – inhibits apoptosis

Q

Tx for indolent NHL?

A

Manage for “pushy” nodes

Q

cyclin D1+ ?

A

Mantle cell

Q

CD20+ and CD5+ ?

A

Mantle cell

Q

H. pylori association?

A

MALT lymphoma

Q

Good summary on slide…

A

46

Q

T-cell NHL on boards?

A

Mycosis fungoides

Q

Can you give rituximab for T-cell?

A

Nope, no CD20