week 4 Flashcards
pregnaglionic neurotransmitter for SNS
ACH
preganglionic neurotransmitter for PSNS
ACH
postganglionic neurotransmitter SNS
NE
postganglionic neurotransmitter PSNS
ACH
post-ganglionic receptor SNS
adrenergic
post-ganglionic receptor PSNS
cholinergic
what is acetylcholinesterase
enzyme
lives in synapse
inactivates ACH that’s outside a nerve ending
3 types of cholinergic receptors
1) muscarinic receptor
2) nicotinic neural receptor
3) nicotinic muscle receptor
where and what target is muscarinic receptor located
PSNS
target the smooth and cardiac muscle
where and what target is the nicotinic neural receptor
PSNS and SNS
only at ganglion
target smooth and cardiac muscle
where and what target is nicotinic muscle receptors
neuromuscular junction - not part of PNS/SNS
target is skeletal muscle cell
2 types of cholinergic drugs
1) indirect
2) direct
direct acting, name: action, duration, effects
action: direct muscarinic R agonist
duration: until ACHenzyme degrades
effects: increase GI motility and secretions/vasodilation/increase GU activity/miosis/ decrease BP and HR
indirect acting, name: action, duration
action: binds to ACHe, inhibiting action
duration: prolonged post-synaptic ACH concentration
types of indirect acting cholinergic drugs
1) reversible inhibitors of ACHe
2) irreversible inhibitors of ACHe
duration and primary usage of reversible inhibitors of ACHe
short acting
diagnosis and treatment of myasthenia gravis
Alzheimers
duration and primary usage of irreversible inhibitors of ACHe
irreversibly bind to ACHe, causing structural change
long acting
primary: chemical warfare, pesticides
low doses: treatment of glaucoma
another name for cholinergic drug
Parasympathomimetic
another name for anticholinergic drug
parasympatholytic