WEEK 4 Flashcards

1
Q

arterial blood
lithium heparin

A

ABG

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2
Q

can yield a hydrogen ion (H)
donor

A

acids

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3
Q

can yield hydroxyl ions
acceptor

A

base

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4
Q

weak acid
weak base, salt
bicarbonate (HCO3)

A

buffer

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5
Q

Principal mammalian buffer system

A

BICARBONATE-CARBONIC ACID
BUFFER SYSTEM

HCO3>H2CO3

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6
Q

unstable, changing to H2O and CO2 in
fluid

A

H2CO3, carbonic acid

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7
Q

Phosphate form that
acts as a buffer

A

2,3-diphosphoglycerate

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8
Q

It increases the amount of NaHCO3 in ECF
(more alkaline)

A

PHOSPHATE BUFFER SYSTEM

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9
Q

16% of the non-bicarbonate buffer value of
Erythrocytes

A

PHOSPHATE BUFFER SYSTEM

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10
Q

Maintains pH level (Venous and Arterial Blood)

A

HEMOGLOBIN-OXYHEMOGLOBIN
BUFFER SYSTEM

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11
Q

1 gram of Hemoglobin carries – of
Oxygen

A

1.39 mL

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12
Q

Proteins can exist in 2 forms: H+ protein, B
Protein

A

PROTEIN BUFFER SYSTEM

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13
Q

Capability to bind or release excess Hydrogen
as required

A

PROTEIN BUFFER SYSTEM

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14
Q

Plasma proteins (Charges on their surface)
* pH > pI – charge

A

-

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15
Q

Plasma proteins (Charges on their surface)
* pH < pI – charge

A

+

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16
Q

The second largest fraction of the anions in
the plasma. It includes the ionized
bicarbonate (HC03), carbonate and the
carbamino compounds.

A

BICARBONATE (HCO3)

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17
Q

This fraction of blood, plasma or serum
Includes the undissociated carbonic acid and
the physically dissolved anhydrous C02

A

CARBONIC ACID (H2CO3 )

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18
Q

The pressure or tension exerted by C02 gas
dissolved in blood. It is an index of efficiency
of gas exchange in the lungs and not a
measure of C02 concentration in the blood.

A

PARTIAL PRESSURE OF C02
(pC02)

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19
Q

Normal range is 35 - 45 mmHg

A

PARTIAL PRESSURE OF C02
(pC02)

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20
Q

an
index of the amount of CO2 that can be bound
by serum, plasma, or whole blood as HCO3 at a
pCO2 of 40 mmHg at 25 degrees Celcius.

A

CARBON DIOXIDE COMBINING
POWER (CO2 combining power)

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21
Q

consisting of ionized HC03, C03, carbamino
compound) and unionized fraction (H2C03) and
physically dissolved C02

A

TOTAL CARBON DIOXIDE
CONCENTRATION (ctCO2)

22
Q

The negative logarithm of hydrogen ion
activity with a normal average range of
7.35-7.45

A

pH

23
Q

Based on amperometric or polarographic
measurement of oxygen.

A

Clark p02 electrode

24
Q

Calculation from oxygen saturation, pH and
temperature by means of the standard 02
dissociation curve.

A

p02

25
Q
  • Gasometric analysis
  • Transcutaneous monitoring
A

p02

26
Q

Based on pH measurement of a
stationary NaHCO3 solution which is in
equilibrium with the test solution and the test via
a CO2 permeable membrane

A

pC02 electrode

27
Q

From a measured pH value interpolated in
the C02 equilibrium curve

A

pC02

28
Q

Based on polarographic principle

A

PH electrode

29
Q

Nomogram and Slide Rule
* Siggard -Anderson Alignment nomogram

A

pH

30
Q

Manometric Method Using Natelson
Microgasometer

A

ct C02

31
Q

Carbon dioxide is released front HC03 by the
addition of lactic add. The C02 and other gases
are, extracted under a partial vacuum. The
pressure difference at constant value before and
after absorption of C02 by NaOH Is the amount of
C02 present in the sample

A

Manometric Method Using Natelson
Microgasometer

32
Q

NATELSON MICROGASOMETER

release CO2 from HCO3

A

10% lactic acidd

33
Q

NATELSON MICROGASOMETER

for total reabsorption of CO2 gas as Na2CO3

A

12% NaOH

34
Q

NATELSON MICROGASOMETER

for total reabsorption of O2

A

NaHSO3

35
Q

NATELSON MICROGASOMETER

seperates the sample and other reagents prevents introduction of air and seals gasometer

A

mercury

36
Q

NATELSON MICROGASOMETER

washes the sample and reagent into the reaction chamber

A

distilled water

37
Q

General term applied for the any condition where
the pH of the blood and the bicarbonate
concentration of the blood are below normal.

A

Acidosis

38
Q

General term applied for any condition with an
increase in blood pH (above normal range)
characterized by an elevation in the H+ ion
accepting buffer of the plasma (UC03) and a
reduction in the H+ ion substances (H2CO3)

A

Alkalosis

39
Q
  • Caused by bicarbonate deficiency
A

Metabolic Acidosis

40
Q
  • Compensation: Hyperventilation
A

Metabolic Acidosis

41
Q
  • (+) Hyperkalemia and hyperchloremia
A

Metabolic Acidosis

42
Q

Production of increased amount of acid –
diabetic ketoacidosis, lactic acidosis
(alcoholism), renal failure and diarrhea

A

Metabolic Acidosis

43
Q
  • Caused by bicarbonate excess
A

Metabolic Alkalosis

44
Q

Conditions: Vomiting with the loss of chloride from
the stomach

A

Metabolic Alkalosis

45
Q
  • Compensation: Hypoventilation
A

Metabolic Alkalosis

46
Q

For every 10 meq/L rise in bicarbonates, the pCO2
rises by 6 mmHg

  • (+) hypokalemia, hypochloremia
A

Metabolic Alkalosis

47
Q
  • Excessive CO2 accumulation
A

Respiratory Acidosis

48
Q
  • Conditions: Chronic obstructive pulmonic
    disease (COPD), myasthenia gravis, CNS
    disease, drug overdose (morphine,
    barbiturates and opiates), pneumonia
A

Respiratory Acidosis

49
Q
  • Compensation: retention of bicarbonates
A

Respiratory Acidosis

50
Q
  • Due to excessive carbon dioxide loss
A

Respiratory Alkalosis

51
Q
  • Conditions: Anxiety, severe pain, aspirin
    overdose, hepatic cirrhosis
A

Respiratory Alkalosis

52
Q
  • Compensation: decreased reabsorption
A

Respiratory Alkalosis