Week 3 (Exam 1): Intro to Homeostasis, Endocrine System; Human Reproductive Cycles Flashcards
g protein-coupled receptors
a large family of cell-surface molecules composed of a single polypeptide chain w/ 7 transmembrane spanning regions; when activated, they associate with a G protein
how fast are cellular responses to the activation of a G protein-coupled receptor?
rapid
what did G protein-coupled receptors evolve from?
sensory receptors in unicellular eukaryotes
when are G protein-coupled receptors inactive?
in the absence of a ligand, and when it is bound to GDP
when are G protein-coupled receptors active?
when they are bound to a ligand, and when it is bound to GTP
what components are G proteins made up of?
alpha, beta, and gamma subunits
first step of the activation of G protein by a G protein-coupled receptor
when the alpha subunit is bound to GDP, the 3 subunits are joined together & G protein is inactive
second step of the activation of G protein by a G protein-coupled receptor
G protein associates w/ an activated receptor; GDP is released by GTP; beta & gamma subunits separate
third step of the activation of G protein by a G protein-coupled receptor
activated alpha subunit binds to & activates a target protein —> cell response
second messenger
an intermediate, cytosolic signaling molecule that transmits signals from a receptor to a target within the cell
first messenger
transmits signals from outside the cell to a receptor
first step of adrenaline signaling in heart muscle
activated adenylyl cyclase converts ATP into the 2nd messenger cAMP, which activates protein kinase A
second step of adrenaline signaling in heart muscle
activated protein kinase A phosphorylates proteins in the heart muscle, causing heart rate to increase
binding affinity
the tightness of the binding between the receptor & the signaling molecule
first step of termination
adrenaline detaches from the receptor, inactivating the receptor
second step of termination
an activated G protein deactivates itself by converting GTP to GDP
third step of termination
enzymes in the cytosol degrade to cAMP, which stops the phosphorylation & activation of target proteins by PKA
fourth step of termination
phosphatases remove phosphate groups from proteins, causing them to become inactive
homeostasis
the active regulation & maintenance of a stable internal physiological state in the face of a changing external environment
negative feedback
a process in which the output or product of a pathway opposes the initial stimulus, so that steady conditions are maintained
set point
a steady-state value in homeostatic regulation
thermoregulation
the ability to maintain a constant body temperature
endocrine system
a system of cells & glands that secretes hormones into the bloodstream & works w/ the nervous system to regulate an animal’s internal physiological functions
hormones
a chemical signal that influences physiology & development in both plants & animals; in animals, hormones are released into the bloodstream & circulate throughout the body
neurosecretory cells
a neuron in the vertebrate hypothalamus & the posterior pituitary gland that separates hormones into the bloodstsream
pituitary gland
an endocrine gland located at the base of the vertebrate brain that produces a number of different hormones & controls many other organs of the endocrine system
two kinds of hormones
hydrophilic & hydrophobic
peptide hormones
a short chain of linked amino acids
-hydrophilic
amine hormones
derived from a single aromatic amino acid such as tyrosine
-hydrophilic
steroid hormones
derived from cholesterol
-hydrophobic
1st set of signaling steps
passing of a signal from one endocrine gland to the next in a hormonal pathway
2nd step
signal transduction in a target cell
releasing hormones
peptide hormones that bind to receptors on cells in the anterior pituitary gland, leading that organ to release a much larger amount of the associated hormones
which hormone is released by the hypothalamus
releasing hormones (peptides)
what is the target gland of the releasing hormones
anterior pituitary gland
what is the action of the releasing hormones
stimulates secretion of anterior pituitary hormones
what hormones do the anterior pituitary gland release
-thyroid-stimulating hormone (TSH) (glycoprotein)
-follicle-stimulating hormone (FSH) (glycoprotein)
-luteinizing hormone (LH) (glycoprotein)
-adrenocorticotropic hormone (ACTH) (peptide)
-growth hormone (GH) (protein)
-prolactin (protein)
-melanocyte-stimulating hormone (peptide)
what gland secretes thyroid-stimulating hormone (TSH) (glycoprotein)
anterior pituitary gland
what gland secretes the follicle-secreting hormone (FSH) (glycoprotein)
anterior pituitary gland
what gland secretes the luteinizing hormone (LH) (glycoprotein)
anterior pituitary gland
what gland secretes the adrenocorticotropic hormone (ACTH) (peptide)
anterior pituitary gland
what gland secretes the growth hormone (GH) (protein)
anterior pituitary gland
what gland secretes the prolactin (protein)
anterior pituitary gland
what gland secretes the melanocyte-stimulating hormone (peptide)
anterior pituitary gland
what gland does the thyroid-stimulating hormone (TSH) (glycoprotein) target
the thyroid gland
what does the thyroid-stimulating hormone (TSH) (glycoprotein) do
stimulates synthesis and secretion of thyroid hormones by the thyroid gland
what organ does the follicle-stimulating hormone (FSH) (glycoprotein) target
gonads
what does the follicle-stimulating hormone (FSH) (glycoprotein) do
stimulates maturation of eggs in females; stimulates sperm production in males
what organ does the luteinizing hormone (LH) (glycoprotein) target?
gonads