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Infectious Disease > Week 2 > Flashcards

Week 2 Flashcards

1
Q

Vesicular herpesviruses (3)

A

HSV1
HSV2
VZV

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2
Q

Mono-causing herpesviruses (2)

A

EBV

CMV

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3
Q

HHV8 causes

A

Kaposi Sarcoma

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4
Q

Poxviruses (2)

A

Smallpox

Molluscum

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5
Q

Naked Single Stranded Linear DNA virus

A

Parvo

Think dog leash

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6
Q

Naked double stranded linear DNA virus

A

adenovirus

Think two adenoids

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7
Q

Naked double stranded circular DNA virus

A

pappilloma

Think cockring

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8
Q

How do single stranded negative sense RNA viruses replicate?

A

RNA dependent RNA pol (note: all are enveloped)

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9
Q

Single stranded negative sense RNA viruses

A

Paramyxoviruses:
Measles
Mumps

Measles and mumps are nonsense

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10
Q

Single stranded positive sense RNA enveloped viruses

A

Rubella

Rubella sounds like an old west hooker, who is SENSE-ual in her nightgown (envelope)

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11
Q

Single stranded positive sense naked RNA viruses (2)

A

Picornoviridae
Enteroviruses
Bad pico de gallo gives you diarrhea, and you’re naked, whatever

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12
Q

Enteroviruses (5)

A 
Enterovirus
Coxsackievirus
Echovirus
Poliovirus
Rhinovirus

PREE Cox (sorry, Amanda)

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13
Q

Parvo causes _____ in kids

A

Fifth (smacked up cheeks)

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14
Q

Parvo causes _________ in preggerfolk

A

Hydrops fetalis

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15
Q

Other bad sequelae of parvovirus (not slapped cheek, not hydrops)

A

Aplastic anemia

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16
Q

Anti influenza antivirals (4)

A

Amantadine
Rimantadine
Oseltamivir
Zanamivir

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17
Q

Anti-herps (4)

A

Acyclovir
Ganciclovir
Famciclovir
Foscarnet

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18
Q

Anti hepatitis agents (5)

A 
Adefovir
Entecavir
Lamivudine
Tenofovir
Interferon
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19
Q

oseltamivir and zanamivir moa

A

inhibits neuraminidase mediated release from cell

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20
Q

Anti herp drug moa

A

block DNA synthesis from viral DNA

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21
Q

Cyclovir resistance comes from (there were a bunch of questions on this bullshit on the formative) (2)

A

Changes in viral TK

Changes in DNA pol

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22
Q

Ganciclovir adverse effect

A

bone marrow suppression

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23
Q

Cidofivir adverse effects

A

nephrotoxicity and neutropenia

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24
Q

foscarnet adverse effect

A

nephrotoxic

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25
Q

How long you gots to incubate blood cultures before you can call them negative

A

5 days

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26
Q

Enveloped DNA viruses

A

Herpes and Pox

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27
Q

Cell wall active ABX categories (5)

A 
Beta-lactams
Vancomycin
Daptomycin
Aztreonam
Colistin
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28
Q

Beta-Lactam subgroups (3)

A

Penicillins
Cephalosporins
Carbapenems

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29
Q

Beta-lactamase inhibitors don’t go _______

A

across the blood brain barrier

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30
Q

The only Beta-lactam that works for MRSA

A

Ceftaroline

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31
Q

IV Beta-lactam + BL-ase inhibitor

A

Ampicillin/Sulbactam

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32
Q

PO Beta-lactam + BL-ase inhibitor

A

Amoxicillin/Clavulanate

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33
Q

Beta lactam + BL-ase inhibitors cover (4)

A

GPC
GNR
Anaerobes
Nasopharyngeal flora

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34
Q

Nasopharyngeal flora (3)

A

Strep pneumo
H-flu
Moraxella

35
Q

If you want to cover pseudomonas with a PCN:

A

Piperacillin/Tazobactam

36
Q

3 Penicillins

A

PCN
Ampicillin
Nafcillin

37
Q

PCN covers (3)

A

Strep pyogenes / viridans / oral anaerobes

38
Q

Ampicillin covers (2)

A

Enterococcus / nasopharyngeal flora

39
Q

Nafcillin covers (2)

A

MSSA

Group A strep

40
Q

1G cephalosporin (2)

A

Cefazolin / Cefalexin

41
Q

1G cephalosporins cover (2)

A

Group A strep

Gram negative rods

42
Q

3G cephalosporin

A

Ceftriaxone

43
Q

Ceftriaxone can do this thing that other beta-lactams have trouble with

A

Cross the blood brain barrier

44
Q

Ceftriaxone covers

A

Nasopharyngeal flora with Beta-lactamase

45
Q

4G cephalosporin

A

Cefepime

46
Q

Cefepime covers

A

pseudomonas

47
Q

5G cephalosporin

A

Ceftaroline

48
Q

Ceftaroline covers

A

MRSA

49
Q

Carbapenems (2)

A

Imipenem and Meropenem

50
Q

Carbapenems cover

A

Resistant gram negative rods

51
Q

Vancomycin covers (2)

A

GPC and MRSA

52
Q

When would you use vanco for a regular GPC?

A

Penicillin allergy

53
Q

Vanco adverse effect

A

nephrotoxic

54
Q

The “only” route you can use Vanco

A

IV (you can do PO for C diff, but young Henry Rollins was insistent that you can only give it IV: So only IV)

55
Q

If you wanted to give Vanco, but someone has bad kidneys, you should use

A

Dapto

56
Q

Dapto covers

A

Everything vanco covers, plus VRE

57
Q

Dapto route

A

IV only

58
Q

Dapto adverse effect

A

elevated CK

59
Q

Gram negative rods, penicillin allergy:

A

aztreonam

60
Q

Colistin covers

A

Gram negative rods

61
Q

30s protein synthesis inhibitors (3)

A

Aminoglycosides
Tigecycline
Tetracyclines

62
Q

Aminoglycosides (2)

A

Gentamycin

Amikacin

63
Q

Aminoglycoside adverse effects (2)

A

ototoxic

nephrotoxic

64
Q

Aminoglycosides cover (3)

A 
GNR
pseudomonas
enterococcus endocarditis (with ampicillin or vanco)
65
Q

Tetracyclines cover (5)

A 
GAS
MSSA
some MRSA
Intracellular
GNR
66
Q

Tetracycline adverse effects (3)

A

Teeth/bone

ototoxic

67
Q

50s protein synthesis inhibitors (3)

A

Macrolides
Clindamycin
Linezolid

68
Q

Macrolide

A

Azithromycin

69
Q

Macrolides cover (4)

A

GAS
MSSA
Intracellulars
Resistant Strep pneumo

70
Q

Macrolide adverse effect

A

Qt prolongation

71
Q

Qt prolongers (2)

A

Quinolones

Macrolides

72
Q

Clindamycin covers (4)

A

GAS
MSSA
Some MRSA
Oral anaerobes

73
Q

If you want to use clindamycin for MRSA, you need this result on this test

A

Negative D test

74
Q

Clindamycin adverse effect

A

diarrhea

75
Q

Linezolid covers (3)

A

GPC
MRSA
VRE

76
Q

Linezolid adverse effects (2)

A

Bone marrow suppression

Neuropathy

77
Q

Nucleic acid synthesis inhibitors (2)

A

Sulfa/trimethoprim

Quinolones

78
Q

Sulfa/trimethoprim covers (3)

A

MSSA
MRSA (sulfatri is the “oral alternative”)
GNR (UTI)

79
Q

Sulfa/trimethoprim does not cover

A

Group A strep

80
Q

Sulfa/trimethoprim adverse effects (4)

A

bone marrow suppression
rash
interstitial nephritis
SJS

81
Q

Quinolones (2)

A

Moxifloxi

Ciprofloxacin

82
Q

Moxifloxacin covers (2)

A 
Nasopharyngeal flora (resistants)
intracellulars
83
Q

Ciprofloxacin covers

A

Gram negative rods

Infectious Disease (7 decks)

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