Week 12 - Beta-adrenergic Antagonists Flashcards
Examples of selective beta blockers
Metoprolol
Atenolol
Metoprolol, Atenolol: indications
- HF
- HTN
- Atrial fibrillation
- Angina
- Treatment post-acute MI
Metoprolol, Atenolol: MOA
Blocks beta-1 receptors at the SA node to decrease HR, contractility in the atria and ventricles, and conduction velocity
Also slows conduction at the AV node
Metoprolol, Atenolol: caution and contraindications
- Do not abruptly withdraw
- Avoid in patients w/ bronchospasms
- Avoid in patients w/ 2nd or 3rd degree AV block
- Caution in peripheral vascular disease
- Caution in diabetic patients
- Caution in hyperlipidemia
Metoprolol, Atenolol: ADR
- Hypotension (including orthostatic)
- Bradycardia
- Dizziness
- Drowsiness
- Fatigue
- Insomnia
- Depression
- Pruritus
- Impotence
- Decreased libido
Rare: anaphylactic reactions
Example of nonselective beta blocker
Propanolol (Inderal)
Propanolol (Inderal): indications
- Atrial fibrillation
- Essential tremor
- Migraine prophylaxis
- HTN
- Stable angina
- Thyroid storm
Propanolol (Inderal): MOA
Competitively blocks response to beta-1 and beta-2 stimulation –> decreased HR, myocardial contractility, BP, and mycardial oxygen demand
Propanolol (Inderal): caution and contraindications
- Do not abruptly withdraw
- Avoid in patients w/ bronchospasms
- Avoid in patients w/ 2nd or 3rd degree AV block
- Caution in peripheral vascular disease
- Caution in diabetic patients
- Caution in hyperlipidemia
Beta-adrenergic physiological activities
- Cardiac acceleration and increased contractility
- Vasodilation of arterioles supplying skeletal muscles
- Bronchial relaxation
- Uterine relaxation
What can beta-1 and beta-2 receptor activation help with in the body?
Beta-1 –> cardiac arrest, HF, shock
Beta-2 –> asthma, premature labor contractions
