Week 12 - Alpha-1 Selective Antagonists Flashcards
1
Q
(-zosins): MOA - HTN
A
Competitively inhibits postsynaptic alpha-1 receptors –> vasodilation of veins and arterioles –> decrease in total peripheral resistance and BP
2
Q
(-zosins): MOA - BPH
A
Competitively inhibits postsynaptic alpha-1 receptors in prostatic stromal and bladder neck tissues –> reduces sympathetic tone-induced urethral stricture causing BPH symptoms
3
Q
(-zosins): caution and contraindications
A
- Caution in HF, angina, recent MI
- Avoid w/ volume depletion
- Caution in renal and hepatic impairment
- Avoid in pregnancy and lactation
4
Q
(-zosins): ADR
A
Fluid retention, nasal congestion, blurred vision, dry mouth, constipation, impotence, urinary frequency, HA, dizziness, fatigue
Rare: priapism, allergic reactions
5
Q
Alpha-adrenergic physiological activities
A
- Vasoconstriction of arterioles –> higher BP
- Pupil dilation
- Relaxation of gut
6
Q
What is the primary use of alpha-1 receptors when activated?
A
- Nasal congestion
- Hypotension
- Dilation of pupils for eye examinations
7
Q
Other adrenergic antagonist indications
A
Raunaud’s disease, migraine HAs
