Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NURS 424 > Week 10 - Systemic Azoles (antifungals) > Flashcards

Week 10 - Systemic Azoles (antifungals) Flashcards

1
Q

Fluconazole: indications

A

Candidiasis - vaginal, oropharyngeal, esophageal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fluconazole: MOA

A

Interferes w/ fungal cytP450 activity, decreasing ergosterol synthesis (principle sterol in fungal cell membrane) and inhibiting cell membrane formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Fluconazole: caution and contraindications

A
  • Risk of QT prolongation
  • Caution in patients with arrhythmias
  • Caution in renal and hepatic impairment
  • Avoid in pregnancy and lactation
  • Approved in pediatrics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fluconazole: ADR

A

HA, dizziness, N/V/D

Rare: hepatoxicity, anaphylaxis, skin reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Itraconazole: indications

A

Onychomycosis (infection of nail bed)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Itraconazole: MOA

A

Interferes with fungal cytP450 activity, decreasing ergosterol synthesis (principle sterol in fungal cell membrane), and inhibiting cell membrane formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Itraconazole: caution and contraindications

A
  • BLACK BOX: avoid in patients with HF
  • Risk for QT prolongation
  • Caution in patients with arrhythmias
  • Caution in renal and hepatic impairment
  • Avoid in pregnancy and lactation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Itraconazole: ADR

A

HA, skin rash, edema, V/D

Rare: hepatotoxicity, skin reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Terbinafine: indications

A

Onychomycosis

1st line treatment option

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Terbinafine: MOA

A

Synthetic allylamine derivative that inhibits squalene epoxidase (key enzyme in sterol biosynthesis in fungi) –> fungal cell death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Terbinafine: caution and contraindications

A
  • Caution in patients with arrhythmias
  • Caution in renal and hepatic impairment
  • Avoid in pregnancy and lactation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Terbinafine: ADR

A

HA, depression, taste disturbance, N/V/D

Rare: hepatotoxicity, hepatic failure, skin reactions, ocular effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which systemic azoles inhibit CYP3A4?

A

Fluconazole, itraconazole, ketoconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which systemic azoles have interactions w/ ingested materials that can effect absorption?

A

Itraconazole = enhanced by food

Griseofulvin = enhanced by fat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Systemic azoles: ADR

A

Hepatotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which systemic azole has the fewest drug interactions but has growing resistance?

A

Fluconazole

17
Q

What labs should be monitored in patients taking ketoconazole?

A

AST, ALT, phosphatase, bilirubin

NURS 424 (35 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions