Week 10 - Fluoroquinolones

Question 1

Fluoroquinolones: examples

Answer 1

Ciprofloxacin, Levofloxacin

Question 2

Fluoroquinolones (-floxacin): activity

Answer 2

Broad spectrum w/ good coverage for gram (-) bacteria

E. coli, h. flu, m. catarrhalis, p. aeruginosa, s. pneumonia, mycoplasma

Question 3

Fluoroquinolones (-floxacin): MOA

Answer 3

Bactericidal through interference w/ enzymes required for synthesis and repair of bacterial DNA and promotes breakage of DNA strands

Question 4

Fluoroquinolones (-floxacin): ADR

Answer 4

HA, insomnia, dizziness, N/V/D, phototoxicity

Rare: hypersensitivity reactions, tendinitis, tendon rupture, c. diff

Question 5

Fluoroquinolones (-floxacin): caution and contraindications

Answer 5

• BLACK BOX: tendon rupture and tendonitis
• Risk for QT prolongation
• Avoid in patients with myasthenia gravis
• Caution in renal and hepatic impairment
• Caution in elderly (dose reduce)
• Caution in pregnancy and lactation (avoid in patients <18 years)

Question 6

Why can’t fluroquinolones be used to treat gonorrhea and TB anymore?

Answer 6

Increasing resistance because of overprescribing

No longer first line

Question 7

Fluroquinolone: indications

Answer 7

• Complicated UTI, pyelonephritis, chronic bacterial prostatitis
• PNA/chronic bronchitis exacerbation

Question 8

Fluoroquinolone: patient education

Answer 8

• Food delays absorption
• Take w/ full glass of water
• If tendon rupture occurs, d/c immediately and notify provider