week 12 Flashcards
What is Anandamide
our bodies endogenous cannabinoid
short-acting
acts on inhibitory pathways mediating dopamine release
How does heroin work?
Heroin mimics natural opiates, binding to opiate receptors - which when activated prevent the release of INHIBITORY NEUROTRANSMITTERS.
The inhibitory neurotransmitters ordinarily prevent the release of DOPAMINE, which can now flood the synapse
How does ecstasy work?
Ecstasy mimics serotonin and is taken up by serotonin transporters (which usually remove serotonin from the synapse).
This confuses the transporter, which starts to work in reverse, transporting serotonin out into the synapse where it becomes trapped overstimulating cell
How does marijuana work?
THC mimics anandamide binding to cannabinoid receptors, turning of inhibitory neurotransmitters which prevent the release of dopamine.
This means more dopamine
How does methamphetamine work?
Meth mimics dopamine and is taken into the synaptic cleft by dopamine transports. Once inside it enters the dopamine vesicles, forcing dopamine out…. the excess dopamine is then released via the transporters working in reverse
How does alcohol work?
binds to GABA receptors making them more inhibitory and also Binds to GLUTAMATE to prevent cell excitation.
Double suppressant
How does cocaine work?
Blocks dopamine reuptake transporters, trapping dopamine in the synaptic cleft
How does LSD work?
Resembles serotonin and binds to serotonin receptors
Reacts with various types of serotonin receptors but not always in the same way. some of them it may excite, some it may inhibit.
What is the formula for Volume required?
( Stock required / stock strength ) X Stock volume
What is the formula for Infusion rate?
Volume / Time
What is the formula for Drops per minute?
Drip factor (20 drops per 1mL) X Infusion rate
What is formula for fluid in burns?
% burns x weight
What is the formula for BP?
Cardiac output X total peripheral resistance
What is the formula for Cardiac output?
Heart rate X Stroke Volume
What is the formula for Stroke Volume?
End diastolic volume - end systolic volume
