Week 11 Flashcards

1
Q

What are the 3 most commonly used non-therapeutic drugs in western society?

A
  • nicotine
  • caffeine
  • ethanol
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2
Q

What are the different aspects/effetcs of drug abuse?

PROBS IMPORTANT

A
  • Intoxication (accidents, injuries, aggression, legal problems, self harm)
  • Regular use (health problems, financial problems, work related issues, interpersonal - family friends etc)
  • Dependence (physical withdrawal, isolation, housing problems, financial and work problems, health problems)
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3
Q

When does a drug (drug abuse) become a problem

A
  • the need for the drug becomes so persistent that it dominates the lifestyle of the individual and damages his/her quality of life
  • The habit itself causes harm to the individual or community
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4
Q

What are some examples of individual harm due to drug abuse?

A

Individual harm
- high risk of infection by poor practice
- Pathological processes associated with chronic use
- Nasal seotum issues with cocaine
- CVS issues with injecting
Oral issues with inhalational drugs
- Respiratory arrest with narcotics

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5
Q

What types of societal harm occur from drug abuse?

A
  • Criminal activity to finance drug habit

- effect of dependence can impact society in a number of ways

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6
Q

What are some risk factors of health care professionals in relation to drug abuse?

A

Stress

  • high stress work, exposure to trauma
  • organisational stress
  • shift work
  • disrupted sleep patterns
  • undeveloped opportunities for debriefing, reflection and peer supervision
  • access to drugs
  • fear of ramifications
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7
Q

Why do people use drugs?

A

drugs occur as a maladaptive coping machanism

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8
Q

What are the three most important predictors of drug abuse?

A
  • rebelliousness
  • tolerance of deviance
  • low school performance
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9
Q

What is drug dependence?

A

The human condition in which drug taking becomes compulsive, taking precedence over other needs, often with serious adverse consequences

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10
Q

Why are psychoactive drugs addictive?

A
  • they produce rewarding effects
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11
Q

What is addiction associated with?

A

Positive reinforcement

  • addictive qualities of drug depend on nature of drug and context in which administered.
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12
Q

What is psychological dependence?

A

behavioural pattern characterised by out-of-control cravings for the pleasure of a drugs effects, denial of excessive drug use and continued use despite personal difficulties

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13
Q

How can social dependence influence drug abuse?

A

social dependence can lead to substance abuse

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14
Q

What is physical dependence?

A

Intense physical disturbances brought about when administration of the drug is withheld

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15
Q

What is drug tolerance?

A

The decrease in pharmacological effect on repeated administration of the drug

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16
Q

What is tachyphylaxis?

ON EXAM!

A

A rapidly diminishing response to successive doses of a drug, rendering it less effective

17
Q

How does reward and drug addiction work?

A

Positive reinforcement
- rewards

Negative reinforcement
- withdrawals and abstinence syndrome

18
Q

What causes the reinforcing effects and psychological dependence of drugs?

A

increased dopamine release in brain

  • addictive drugs increase dopamine levels in the nucleus accumbens
  • The nucleus accumbens is involved in motivation reward and positive reinforcement
19
Q

what is the role of dopamine in the brain?

A

Behaviour
(social interaction/energy/reward/reinforce ent/appetite suppression/psychosis/delusions)

Fine motor control
(agitation/increase motor activity)

20
Q

What dependence is negative reinforcement associated with?

A

Physical dependence and withdrawal

21
Q

What dependence is positive reinforcement associated with?

A

psychological dependence

22
Q

What are common drugs of abuse?

A
  • Opioids
  • CNS depressants
  • CNS stimulants
  • Psychotomimetics or hallucinogens
23
Q

What are some Drugs in sport

A
  • anabolic steroids
  • sympathomimetics
  • stimulants
  • narcotics
  • analgesics
  • diuretics
  • anti-hypertensives
24
Q

What else do opioid analgesics do besides relieve pain?

A
  • Change or elevate mood
  • relieve tension, fear and anxiety
  • produce feelings of peace, euphoria and tranquility, drowsiness and lethargy
  • decreased BP
  • Respiratory depression
  • Fixed pinpoint pupils
25
What are the 3 type of receptors for opioids?
- mu receptors - delata - kappa - Fentanyl less kappa effect
26
What effects do the mu, kappa and delta receptors have in regards to opioids?
Mu - most of the major effects of opioids such as analgesic, cough suppression, respiratory depression, dependence, sedation and euphoria delta - contribute to analgesic effects of opioids kappa - contribute to analgesic effects of opioids
27
What does morphine mimic?
the effects of endogenous opioids - endorphins - enkephalins
28
What are endogenous opioids?
Small peptides (neuropeptide transmitter) released from nearby neurons
29
What are some CNS depressants?
- Benzodiazepines - barbiturates - anaesthetics agents - inhalational solvents - alcohol
30
What are the effects of CNS depressants?
- Depression of CNS - Drowsiness - Confusion - Disinhibition - Impaired coordination and judgement - Decreased BP and RR
31
What can happen with recurrent use of CNS stimulants?
- increase anxiety and paranoia | - and depressants can be used to control these symptoms
32
List the pharmakokinetics of alcohol
- very water soluble - small size means easily crosses lipid membranes - Crosses BBB - Absorbed in stomach but mostly in small intestine - 90% is metabolised in lover - rest excreted by lungs and sweat and kidneys
33
What are the two main enzymes used for metabolising alcohol?
- Alcohol dehydrogenase (ADH) | - Aldehyde dehydrogenase (ALDH)
34
List some pharmacodynamics of alcohol?
- CNS depressant - Enhances GABA-A - Stimulates 5-HT3 receptors - Inhibits NMDA excitatory amino acid receptor - Opioid effects
35
How does alcohol affect the brain?
Frontal lobe - loss of reason, caution and inhibitions Parietal lobe - loss of fine motor skills, slower reaction time Temporal lobe - originates the slurred speech Occipital lobe - Blurred vision and distance judgement Brain stem - vital functions if effected
36
What are the 3 triads of symptoms of serotonin syndrome?
- Autonomic instability - Neuromuscular hyperactivity - Mental status changes
37
What are some pharmacological effects of MDMA?
- increased HR & BP - apetitie loss - trismus - headaches - hyperthermia/ dehydration/ hyponatremia
38
What is tachyphylaxis?
A rapidly diminishing response to successive doses of a drug, rendering it less effective