Week 11 Lectures Flashcards
What is genome?
definition and size range
How many genomes do we have?
6 billion base pairs of DNA
What is the length of our DNA?
2 yards
What is the thickness of our DNA
Thickness of a sewing thread
What is heterchromatin?
It is a condensed, silenced gene(methylated), poor gene(low AT), and stains darker
What is euchromatin?
Less condensed, more gene expressing, rich in gene(high GC), and stains lighter
What is true about heterochromatin?
Contains lots of repeated sequences
What is true about what we know about genome?
We don’t know much. Very little is focused on protein coding.
How many base pairs do we have?
3.2 billion
What was the goal of the human genome project?
Get the linear DNA sequence for all 23 chromosomes in a human cell
Why sequence the human genome?
Know about human disease, treat them, accurately predict disease onset, learn about evolutionary history, and learn how cells are built and how they work
Who figured the insulin protein sequence?
Fred Sanger
How was DNA sequenced during the 70/80s
by hand
What were the first projects during the genome project?
Virus which took 4 years
What happened during the human genome project as time passed?
1 person could sequence by hand 100,000 base pairs of DNA in a year
What was the goal of Venter?
Sequence the human genome project for profit. He claimed that he could do the project in 3 years and people were too slow.
What is the goal of Francis Collins?
Sequence the human genome project for the benefit of mankind
Who did Francis want the Project for?
Data for everyone to the people for free
Who did Venter want the Project for?
Sell the sequence to drug companies and patent genes
