Week 11 General Sensation (A Focus On Pain)

Question 1

Nociceptors

Answer 1

Sense tissue damage, physical trauma or thermal injury

Question 2

Psychogenic Pain

Answer 2

Pain that arises from (or is linked to) states of mind such as depression or anxiety

Question 3

TRP Channels

Answer 3

Transient receptor potential cation (TRP) channels

Question 4

Transient receptor potential cation (TRP) channels

Answer 4

Open in response to various stimuli; Huge diversity of channel types; generate EPSPs in sensory cell

Question 5

1

Answer 5

Third order neuron

Question 6

2

Answer 6

Thalamus

Question 7

3

Answer 7

Second order neuron

Question 8

4

Answer 8

Spinothalamic tract

Question 9

5

Answer 9

Dorsal root ganglion

Question 10

6

Answer 10

First order neuron

Question 11

Two types of first order sensory neurons for pain

Answer 11

A-Delta fiber and C fiber

Question 12

A-Delta fiber

Answer 12

First pain; lightly myelinated medium diameter Nociception

Question 13

C Fiber

Answer 13

Second pain; un-myelinated smaller diameter innocuous temperature, itch nociception

Question 14

First order sensory neurons

Answer 14

-Begin at nerve ending
-Cell body in dorsal root ganglion
-synapse with interneurons in dorsal horn

Question 15

Second order interneurons

Answer 15

-Have cell body within dorsal horn
-Decussate in spinal cord and end at thalamus

Question 16

Third-order neurons

Answer 16

-Axons project to somatosensory cortex

Question 17

Endogenous opioids

Answer 17

Endorphins, enkephalins, dynorphins; produced within your own body

Question 18

Synthetic Opioids

Answer 18

Inhibit pain transmission at central synapses E.g. morphine, codeine

Question 19

Which fiber type has the slowest conduction velocity to the CNS?

Answer 19

C

Question 20

The second order neuron in a ascending sensory pathway is found ______________.

Answer 20

Within the spinal cord or brainstem

Question 21

The process by which sensory information is interpreted in a meaningful form is know as _________________.

Answer 21

Perception

Question 22

Nociceptors detect change in ____________.

Answer 22

Pain