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PHAN 1 LEC > WEEK 11&12 > Flashcards

WEEK 11&12 Flashcards

1
Q

Assay of Hydrogen Peroxide TITRANT

A

KMnO4

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2
Q

Assay of Hydrogen Peroxide ANALYTE

A

H2O2 HYDROGEN PEROXIDE

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3
Q

Assay of Hydrogen Peroxide INDICATOR

A

KMnO4

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4
Q

Assay of Hydrogen Peroxide ENDPOINT

A

pink color

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5
Q

Assay of Hydrogen Peroxide CHEMICAL REACTION

A

KMnO4 + H2O2 + H2SO4 — > MnSO4 + K2SO4 + O2 + H2O

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6
Q

Assay of Hydrogen Peroxide AMOUNT OF ANALYTE

A

2mL

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7
Q

MW OF H2O2

A

34

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8
Q

mEq OF H2O2

A

0.017

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9
Q

USP REQT FOR H2O2

A

2.5-3.5%

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10
Q

%H2O2 =

A

Vol. of KMnO4 x N x (H2O2/2000)/
Vol. of H2O2 used

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11
Q

H2O2 USP requirement per 100 ml is

A

nlt 2.5g and nmt 3.5 g

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12
Q

Oxidizing agent, wound cleanser

A

H2O2

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13
Q

DIRECT PERMANGANATE METHOD

A

H2O2
KBr

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14
Q

INDIRECT PERMANGANATE METHOD

A

MALIC ACID IN CHERRY JUICE
TiO2
MnO2

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15
Q

generally applies to the
products from plant and animal origin found in a raw
form.

A

crude drug

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16
Q

outlines the different methods of analysis that
include physical and chemical tests. The
objective is to establish the identity and
conformity to set standards.
Pharmaceutical Analysis I Laboratory

A

USP <56> Articles of Botanical Origin

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17
Q

allows more detailed examination of a drug and it
can be used to identify the organised drugs by their
known histological characters

A

Microscopic examination

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18
Q

mostly used for qualitative evaluation of organised
crude drugs in entire and powdered forms.

A

Microscopic examination

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19
Q

can be used to distinguish cellular structure

A

stains

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20
Q

Lignin- phloroglucinol and concentrated hydrochloric
acid give

A

red stain

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21
Q

Mucilage - stained

A

pink with rhuthenium red

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22
Q

TLC
* Principle :

A

Adsorption

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23
Q

useful to analyse Alkaloids, Glycosides like all bio-
constituents

A

TLC

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24
Q

The parts of the organ or organs other than those
parts of drugs mentioned in the definition and
description of the drug are known as

A

Foreign matter

25
Q

Amount of volatile matter of any kind that is driven
off at 110-120 DEGREES CELSIUS.

A

Loss on Drying

26
Q

Sodium Chloride
* USP Requirement:

A

NMT 0.25 % loss of weight

27
Q

Loss of weight of sample =

A

weight of sample – weight of dried sample

28
Q

%Loss on drying =

A

loss of weight of sample x 100/
Weight of sample

29
Q

can be determined by heating the drug at 150⁰C in
an oven to a constant weight and calculating the
loss of weight

A

Moisture content

30
Q

Methods for the determination of
moisture content

A
  1. Gravimetric method (w,v)
  2. Gravimetric method (e)
  3. Azeotropic method or toluene distillation
  4. Titrimetric method or karl fischer method
  5. Dew point method
  6. Electrolytic hygrometric
31
Q

1 mL of the reagent is equivalent to approximately _
milligrams of water

A

5

32
Q

Primary standard KARL FISHER REAGENT:

A

Na Tartrate

33
Q

react with water to SO3

A

Sulfur dioxide

34
Q

prevent reversibility of rxn

A

Pyridine

35
Q

prevent pyridine-S complex

A

Anhydrous methanol

36
Q

rx with HI

A

Iodine

37
Q

Azeotropic Method/ Toluene
Distillation Method
Solvent:

A

Toluene and xylene

38
Q

Method of choice for chemical samples (1-2
grams),
✓biologics

A

Gravimetric Method/
Drying/Thermal Method

39
Q

the extracts obtained by exhausting crude drugs
with different solvents are approximate measures
of their chemical constituents

A

Extractives

40
Q

Water soluble extractive

A

glycosides, tannins, mucilage

41
Q

Alcohol- soluble extractive

A

tannins, glycosides, resins

42
Q

ether-soluble extractives

A

volatile constituents and fats

43
Q

is the residue left after incineration

A

Total Ash

44
Q

It may also include inorganic matter added for the
purpose of ADULTERATION.

A

TOTAL ASH

45
Q

This may serve as basis for judging the IDENTITY
AND CLEANLINESS of a drug

A

Total Ash

46
Q

useful for detecting low grade products, exhausted
drugs, and excess of sandy or earthy matter

A

Total Ash

47
Q

_______
*For determining ash content
of expensive chemicals.
Igniting the sample to dull
redness and RESIDUE SHOULD
NOT EXCEED _____

A

RESIDUE ON IGNITION

500 ug

48
Q

USP requirement:
* Total ash : NMT _
* Acid insoluble ash : NMT _

A

5 %

1%

49
Q

%Total Ash =

A

weight of ash x 100/
wt. of sample

50
Q

consists almost entirely of silica derived from the soil
adhering to the drug.

A

Acid-insoluble ash

51
Q

Used for the determination of earthy matter present on
roots, rhizomes, and also on the leaves, Crude drugs contain
calcium oxalate crystals the amount may varies depending
on the environmental conditions.

A

Acid-insoluble ash

52
Q

Part of the total ash that is insoluble with diluted
hydrochloric acid

A

Acid-insoluble ash

53
Q

% Acid-insoluble ash =

A

wt of the acid-insoluble ash x 100/
wt of the sample

54
Q

Calcium carbonate- calcium oxalate

A

825 C

55
Q

Calcium phosphate – calcium pyrophosphate

A

1550 C

56
Q

Lithium carbonate – lithium oxide

A

600 C

57
Q

Potassium chloride – sublimes

A

1500 C

58
Q

is the process of removing extraneous
matter, such as other parts of the plant, dirt, and added
adulterants

A

Garbling

PHAN 1 LEC (13 decks)

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