week 1-5 Flashcards

1
Q

What cells are the first responders to infection

A

Myeloid cells

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2
Q

first line of defence?

A

innate immune cells

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3
Q

Cellular Bridge btw innate and Adaptive immunity?

A

APCs- Antigen presenting cells
(DCs, B-cells, mf)

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4
Q

——— is the process by which Hematopoietic stem cells (HSC) differentiate into mature RBCs (and leukocytes)

A

Hematopoiesis

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5
Q

HSCs are directed to differentiate into two major types of progenitors ———— or ——— progenitor cell

A

HSCs are directed to differentiate into two major types of progenitors lymphoid progenitor cell or myeloid progenitor cell

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6
Q

Failure of Hematopoietic regulatory mechanisms can have seroious consequences such as?

A

Leukemia

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7
Q

Myeloid progenitor cells diffrentiate into?

A

mf, DCs, neutrophils, Basophils, Monocytes, Mast cells, WBCs, RBCs

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8
Q

Lymphoid Progenitor cells diffrentiate into?

A

T-cells, B-cells, NK cells and DCs

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9
Q

Fxn of Myeloid cells

A

1) detection of pathogens via PRRs
2) phagocytosis
3) escalate imune responses through cytokine and chemokine secretion

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10
Q

——– presence in tissue indicates an active immune response

A

Granulocytes (neurtorphils, eosinophil, basophils, mast cells)

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11
Q

Provide the major defense against pus-forming (pyogenic) bacteria such as streptococci and staphylococci and fungi?

A

Neutrophils

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12
Q

cells that make up APCs ?

A

DCs , macrophages, B-cells, monocytes

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13
Q

fxn of APCs

A

part of the first line defence against pathogens
* Act as cellular bridges btw innate and Adaptive immunity

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14
Q

fxn of Macrophages

A

Regulation of the immune response through production of pro-inflammatory (IL-1, TNF, IL-6) and anti-inflammatory (TGFβ, ΙL-10) cytokines

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15
Q

Pro -inflammatory cytokines

A

IL-1, TNF, IL-6

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16
Q

Anti-inflammatory Cytokines

A

TGFβ, ΙL-10

17
Q

Mutation in signaling molecules affecting TLRs will cause?

A

Recurrent, severe bacterial infections (pneumonia)

18
Q

Gain of function mutations in inflammasome will cause?

A

1)Gout
2)Atherosclerosis
3)Type II diabetes
4)Familial Mediterranean Fever (FMF)

19
Q

NOD2 mutations are associated with enhanced susceptibility to ———-

A

Crohn’s disease

20
Q

IL-12 and IFN-γ receptor deficiency will cause?

A

Increased susceptibility to intracellular infections (mycobacterium tuberculosis)

21
Q

Fxn of IL-8

A

neutrophil chemoatractant

22
Q

———— are released by the liver in resposne to inflammation?

A

Acute-phase proteins are released by the liver in response to inflammation (IL-6, TNF, IL-1β pro-inflammatory cytokines)

23
Q

examples of acute-phase proteins released by the liver

24
Q

Cytokines that maintain granuloma

A

IFN-γ (produced by the activation of Th cells)

* Also maintains macrophage activation

25
Cytokine that aids the formation of granulomas
**TNF**
26
why is **IL-2** given to AIDS patients in combo w/ antiretrovirals
To restore the decreased levels of **CD4+ T cells**
27
Fxn of IL-12
1) Promotes the development of CD4+ T cells 2) induces the production of IFN-γ (by activating TH cells) | * **Pro-inflammatory cytokine**
28
**----** inhibitis Th and Tc activation
**anti-CD25** (Ab against IL-2 receptor) | CD25--> IL-12
29
State the difference in fxn btw granulation tissue and Granulomas
* **Granulation tissue** : part of the repair response, fxn -> healing of injured tissue * **Granuloms** : a form of chronic inflammation, fxn --> phgocytosis
30
Histology of Granulation tissue
1) Newly formed blood vessles (angiogenesis) 2) Fibroblasts 3) mononuclear cells in extracelluar matrix (does not surround an indigestible particle like granulomas)
31
Histology of Granulomas
1) Macrophages (circumsrcibed aggregates of epithelioid cells) 2) surrounded by lymphocytes 3) Giant cells and dead material
32
Which of the following is a caseating granuloma ; TB or Sarcoidosis
**TB**
33
patines w/ severly reduced C3 levels tend to have?
increased numbers of sever **Bacterial** infection
34
**Diganosis:** - - low CD4+ levels on flow Cytometry - normal levels of CD8+ cells and B cells - Hypogammaglobulinemia * **Presenting symtpoms:** numerous, severe infections requiring IV antibiotic, diarrhea and oral candidiasis disroder?
**Bare lymphocyte syndrome type 2** aka MHC class II deficiency * Lack of MHC II due to mutations of regulators of MHC-II transcription (CIITA, RFXANK, RFX5, RFXAP) * Epi: death at around 4 yrs | * similar diganosis to SCID
35
Clues in the diagnosis of SCID
1) presents in **first few weeks/months of life** 2) **Infections** are often **viral**/ fungal rather than bacterial 3) **Chronic diarrheais** common ("Gastroenteritis") 4) **Repiratory infections** and **oral thrush** are common 5) **faliure to thrive** 6) **Lymphopenia** (low WBCs)
36
**Diagnosis:** - **low CD8+ levels** - **Activated NK cells** - normal CD4+ levels - normal antibody production **Presenting symptoms:** - characteristic mark **"necrotizing skin lesions"** on the extremities and midface - Frequent, **Bacterial infections** of the upper respiratory tract diagnosis?
**Βare lymphocyte syndrome type 1:** MHC class I deficiency cause: lack of expression of **TAP1 and TAP2**
37
Cause of Βare lymphocyte syndrome type 1: MHC class I deficiency
lack of expression of TAP1 and TAP2