Important mediators

Question 1

Fxn of Histamins

* primary mediator

Answer 1

Increased vascular permeability; smooth muscle contraction in GI and Lungs, vasodialtion,

Question 2

Action of Tryptase

* primary mediator

Answer 2

Degradation of blood vessel basement membrane

Question 3

Action of eosinophil chemotactic factor A (ECF-A)

* Primary mediator

Answer 3

Eosinophil chemotaxis

Question 4

fxn of Cytokines (IL-4, IL-5, IL-8, IL9, IL-13, GM-CSF, TNFα)

* secondary mediators

Answer 4

1) Recruitmentand activation of inflammatory cells
2) stimulation of TH2 response and IgE production (IL-4, IL-13),
3) shock in systemic anaphylaxis (TNFα)

Question 5

Action of Leukotriene B4

* secondary

Answer 5

Neutrophil chemotaxis

Question 6

Action of Prostoglandins D2, E2,F2A

* secondary

Answer 6

Increased vascular permeability; smooth muscle contraction

Question 7

Action of Platelet-activating factor (PAF)

* Secondary

Answer 7

Amplifies production of lipid mediators; activates platelets

Question 8

Action of Major basic protein (MBP)

* Primary

Answer 8

Eosinophil-granule protein which causes the release of histamine from mast cells and basophils