Inflammatory disorders 2/ Autoimmune systemic disorders

Question 1

Autoimmune Dermatological condition

Answer 1

Psoriasis

Question 2

Autoimmune Neurological condition

Answer 2

Multiple sclerosis

Question 3

Autoimmine systemic disorders w/ Msck system involvement

Answer 3

1. RA
2. AS
3. Reactive arthritis
4. Reiter’s syndrome

Question 4

symptoms pf Psoriasis

Answer 4

1) dermatological –>** thick, silvery scales** and itchy, dry red patches that are sometimes painful
2) Psoriasis patches can range from a few spots of dandruff-like scaling to major eruptions that cover large areas

Question 5

Symptoms of Rheumatoid arthritis

Answer 5

1) Chronic arthritis
2) joint pain
3) morning stiffness
4) limited range of motions of affected joints
5) Symmetric involvement of the small joints, hands and feet

Question 6

Extraarticular manifestations of Rheumatoid arhthritis

Answer 6

Inflammation sometimes can affect other organs beside the joints for instance, the eyes or lungs

Question 7

classification of RA

Answer 7

seropositive : positive Rheumatoid factor
seronegative : negative Rheumatoid factor

Question 8

**

Serological investigations in RA

Answer 8

ANA , RF, antiCCP

Question 9

———–: Inflammatory disease that, over time, causes fusion of the spinal cord resulting to rigid and less flexible spine. Long term resulting in a hunched-forward posture

Answer 9

Ankylosing spodylitis

Question 10

CF of Ankylosing Spondylitis

Answer 10

1) pain
2) morning stiffness (lower back and hips),
3) neck pain and fatigue also are common
symptoms might worsen, improve or stop at irregular intervals

Question 11

Areas most affected in Ankylosing spondylitis

Answer 11

1) sacroiliac joints , usually bilateral
2) enthesitis, where tendons and ligaments attach to bones
3) tendinitis

Question 12

Serological tests in Ankylosing Spondylitis

Answer 12

HLA b27

Question 13

—— : a painful form of inflammatory arthritis, It occurs in reaction to an infection by certain bacteria (Chlamydia)

Answer 13

Reactive arthritis

Question 14

**

Bacteria that cause Reactive arthritis

Answer 14

1) Chlamydia Tachomatis
2) Salmonella
3) shigella
4) Yersinia
5) Camplylobacter

Question 15

Symptoms of Reactive Arthritis

Answer 15

1) swelling and pain of heels, toes, fingers, low back, and joints, especially knees /ankles
2) extensive swelling of the fingers and toes
3) unilateral - not often symmetric

Question 16

Epi of Reactive arhtritis

Answer 16

Men btw 20-50 yrs

Question 17

Serological tests for Reactive arthritis

Answer 17

positive for
salmonella, Shigella, Yersinina, Campylobacter antibodies

Question 18

Symptoms of Reiter syndrome

Answer 18

1) arthritis often in knees, ankles, and feet
2) conjunctivitis
3) urethritis
self limited between 2 to 6 months

Question 19

Epi Polymyalgia Rheumatica

Answer 19

W>M
* 70 yrs old
* Caucasians

Question 20

* inflammatory disroder

15 percent of people with PMR develop a potentially dangerous condition called ———

* PMR : polymyalgia rheumatica

Answer 20

giant cell arteritis (also known as temporal arteritis)

Question 21

CF of Polymalgia Rheumatica

Answer 21

pain and stiffness in at least 2 of the following areas
1) Buttocks
2) neck
3) hip
4) thigs
5) Upper arms and shoulders

• systemic manifestation: fever, weightloss, poor appetite, fatigues

Question 22

Blood tests for the diagnosis of Polymyalgia Rheumatica

Answer 22

1) ANA
2) Anti-CPP
3) complete blood count- CBC
4) CRP
5) ESR
6) RF

Question 23

Antiphospholipid syndrome CF

Answer 23

2) DVT, PE
3) Transitory ischemic attack (TIA)
4) Repeated miscarriages/ still birth

Question 24

——-: syndrome where the immune system attacks some of the normal proteins in the blood. It can cause blood clots in both arteries or veins

Answer 24

Antiphospholipid syndrome

Question 25

Diagnosis of Antiphospholipid syndrome

Answer 25

ESR, CRP, **b2 glycoprotein**, **Lupus anticoagulant**, **antiphospholipid antibodie**

Question 26

**-----**: systemic connective tissue disease

Answer 26

Systemic sclerosis

Question 27

CF of Systemic sclerosis?

Answer 27

1) Raynauds 2) digital ulcers 3) dysphagia 4) telengiectasias

Question 28

Diagnosis of Systemic sclerosis

Answer 28

ESR, CRP, ANA, ENA - special focus on the **anti-centromere antibodies, RNP**

Question 29

**---------- **a rare autoimmune disorder featuring signs and symptoms of three different disorders: **lupus, scleroderma and polymyositis**

Answer 29

**Mixed connective tissue disease (MCTD)**

Question 30

Mixed connetive tissue disease is a rare autoimmune disorder featuring signs and symptoms of three different disorders: **--------, -----------, ---------**

Answer 30

**Lupus, Scleroderma and Poylmyositis**

Question 31

Symptoms of mixed connective tissue disease

Answer 31

1) systemic sx: **fatigue, mild fever**, 2) **Raynauds**, 3) swelling that gives **fingers a sausage-like appearance** and 4) **muscle and joint pain**. * In the later stages of the disease, the heart, lungs, kidney or other organs may be affected

Question 32

Diagnosis of Mixed connective tissue disease

Answer 32

**RNP - POSITIVE**

Question 33

-------: inflammation of the muscles

Answer 33

Myositis

Question 34

Types of Myositis

Answer 34

1) **polymyositis** 2) Juvenile dermatomyositis 3) **Dermatomyositis** | * juvenile form is the only type w/o symetric muscle weakness

Question 35

Juvenile dermatomyositis differs from the adult form because of the coexistence of **--------**

Answer 35

**Vasculitis**

Question 36

Symptoms of Dermatomyositis

Answer 36

1) muscle weakness 2) muscle pain 3) fatigue 4) difficulty moving limbs 5) difficulty swallowing or breathing **Chracterized by patchy purple rashes in joints of the knuckles, elbows, knees and toes, they can also appear on the face, chest and back**

Question 37

CF of Polymyositis

Answer 37

1) **muscle weakness especially in the thighs, hips and shoulders** 2) **lung issues**, joint pain, fever, weight loss, **Raynaud’s phenomenon** and a general ill feeling